MOESM2 of An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation

Additional file 2: Table S1. Table: Numerical representation of SHAPE reactivity differences at each nucleotide position. Colours shown are the same as those in Fig. 5 and Additional file 3: Fig. S2

MOESM3 of An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation

Additional file 3: Figure S2. Structural effects of NSC on the Δp1 RNA. Δp1 RNA was in vitro transcribed, refolded and treated with DMSO only or NSC in DMSO as for Fig. 5. Acylation sensitivity at each nucleotide was used to model the structure and predicted free energy. The most stable structure is shown. a Predicted RNA structure and stability of DMSO treated RNA. b Predicted RNA structure and stability of NSC treated RNA