Creating a new Ontology: a Modular Approach

Creating a new Ontology: a Modular ApproachComment: in Adrian Paschke, Albert Burger, Andrea Splendiani, M. Scott Marshall, Paolo Romano: Proceedings of the 3rd International Workshop on Semantic Web Applications and Tools for the Life Sciences, Berlin,Germany, December 8-10, 201

The role of paternal and maternal warmth and hostility on daughter’s psychosocial outcomes: The insidious effects of father warmth combined with high paternal hostility

IntroductionDespite the well-accepted view on the importance of parental warmth and parental hostility for adolescent development, few studies have examined the joint interactive effects of these two key aspects of parenting. Furthermore, research comparing maternal and paternal parenting is limited, with the father-daughter relationship during adolescence remaining one of the more understudied familial contexts. Given that family processes are key for the intergenerational transmission of inequality, these parent–child relationships may be especially important for youth at risk for exposure to violence.ObjectivesUsing a sample of juvenile female offenders, this study examined the associations between the perceived warmth and hostility in the father-daughter and mother-daughter relationships on daughters’ depressive symptoms, anxiety symptoms, romantic partner warmth, romantic partner hostility, and the daughter’s sense of agency. We hypothesized that high perceived parental warmth would moderate the effects of parental hostility by protecting daughters from the negative effects of parental hostility, with stronger effects for the father-daughter than the mother-daughter relationship.ResultsIn contrast, our paternal relationship findings across four of the five outcomes suggest a moderation in the opposite direction – that is, high perceived father warmth exacerbates the deleterious effects of father hostility on daughters’ depressive symptoms, anxiety, romantic partner warmth, and romantic partner hostility. Maternal warmth, and not hostility, had a direct association with these four outcomes, with stronger explanatory power shown for the father-daughter than the mother-daughter model. Higher agency was associated with maternal hostility only.ConclusionOur findings suggest that daughters might be modeling and internalizing the relationship with their fathers (for better or worse) when they perceive it as warm and supportive. Consequently, adolescent girls whose fathers exhibit hostile behavior may benefit from emotional distancing from their fathers

The effects of economic and sociocultural stressors on the well-being of children of Latino immigrants living in poverty.

This paper explored whether preschooler's physical (body mass index and salivary cortisol levels) and psychological (internalizing/externalizing behaviors) well-being were predicted by economic hardship as has been previously documented, and further whether parental immigration-related stress and/or acculturation level moderated this relationship in low-income Latino families

Parental Buffering in the Context of Poverty: Positive Parenting Behaviors Differentiate Young Children\u27s Stress Reactivity Profiles

Experiencing poverty increases vulnerability for dysregulated hypothalamic–pituitary–adrenal (HPA) axis functioning and compromises long-term health. Positive parenting buffers children from HPA axis reactivity, yet this has primarily been documented among families not experiencing poverty. We tested the theorized power of positive parenting in 124 parent–child dyads recruited from Early Head Start (Mage = 25.21 months) by examining child cortisol trajectories using five samples collected across a standardized stress paradigm. Piecewise latent growth models revealed that positive parenting buffered children\u27s stress responses when controlling for time of day, last stress task completed, and demographics. Positive parenting also interacted with income such that positive parenting was especially protective for cortisol reactivity in families experiencing greater poverty. Findings suggest that positive parenting behaviors are important for protecting children in families experiencing low income from heightened or prolonged physiologic stress reactivity to an acute stressor

Defining the genetic control of human blood plasma N-glycome using genome-wide association study

Glycosylation is a common post-translational modification of proteins. Glycosylation is associated with a number of human diseases. Defining genetic factors altering glycosylation may provide a basis for novel approaches to diagnostic and pharmaceutical applications. Here we report a genome-wide association study of the human blood plasma N-glycome composition in up to 3811 people measured by Ultra Performance Liquid Chromatography (UPLC) technology. Starting with the 36 original traits measured by UPLC, we computed an additional 77 derived traits leading to a total of 113 glycan traits. We studied associations between these traits and genetic polymorphisms located on human autosomes. We discovered and replicated 12 loci. This allowed us to demonstrate an overlap in genetic control between total plasma protein and IgG glycosylation. The majority of revealed loci contained genes that encode enzymes directly involved in glycosylation (FUT3/FUT6, FUT8, B3GAT1, ST6GAL1, B4GALT1, ST3GAL4, MGAT3 and MGAT5) and a known regulator of plasma protein fucosylation (HNF1A). However, we also found loci that could possibly reflect other more complex aspects of glycosylation process. Functional genomic annotation suggested the role of several genes including DERL3, CHCHD10, TMEM121, IGH and IKZF1. The hypotheses we generated may serve as a starting point for further functional studies in this research area