4,752 research outputs found

    State of Utah v. Mcbride : Unknown

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    HAND-DELIVERED Ms. Julia D\u27Alesandro Clerk of the Court 450 South State Street P.O. Box 140230 Salt Lake City, UT 84114-0230 FILED Utah Court of Appeals MAR 2 4 b99 Julia D\u27Alesandro Clerk of the Court Re: State v. McBride, Case No. 980226-CA - Rule 24(h) Citation of Supplemental Authoritie

    Just Another Girl

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    A non-fiction piece that explores the causes of the author’s depression while in college. While she is able to pinpoint specific events that have led to her unhappiness, she realizes that accepting her life in spite of these obstacles will allow her to move forward

    MS-136: Temma Berg Collection

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    This collection contains 107 letters, postcards and telegrams from Temma Berg in Europe, to her parents, Selma and Charles Silverstein, in Philadelphia. While the majority of the letters are sent from her home in Baarn, Holland, a few were sent from London. The postcards were sent from places they visited during their travels, including Amsterdam, Belgium, Germany, London, Paris and Israel.https://cupola.gettysburg.edu/findingaidsall/1150/thumbnail.jp

    Altruism, Markets, and Organ Procurement

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    For decades, the dominant view among biomedical ethicists, transplantation professionals, and the public at large has been that altruism, not financial considerations, should motivate organ donors. Proposals to compensate sources of transplantable organs or their survivors, although endorsed by a number of economists and legal scholars, have been denounced as unethical and impracticable. Organ transplantation is said to belong to the world of gift, as distinct from the market realm. Paying for organs would inject commerce into a sphere where market values have no place and would transform a system based on generosity and civic spirit into one of antiseptic, bargained-for exchanges. Here, Mahoney discusses a brief history of the restriction on payments to sources of transplantable organs. She then turn to the arguments commonly advanced against compensating organ sources and explain how they are grounded in beliefs that range from the highly contestable to the demonstrably wrong. Furthermore, she examines the most popular compensation proposals, and offering preliminary assessments of their promise and feasibility. She also concludes with some thoughts about the relationship between altruism and self-interest

    MS-133: John F. Kent Collection, Company D, New York First Cavalry Regiment

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    The John F. Kent Collection contains two manuscript diaries of his experiences during the Civil War. The first was written in 1862, the second in 1863. The entries are brief and mention battles in passing, casualties and skirmishes with the rebels. There are 16 letters, one to his parents during the war, 9 between Helen Lund and her sister Francesca, and six between John Kent and Caroline Kitchel about purchasing plots of land in a cemetery. There are assorted documents, ranging from Kent’s father’s naturalization certificate, to recipes, to pension certificates. There are nine photographs, six that are mounted, and three that are in small cases, ranging from portraits to group photos. It also contains Kent’s Grand Army of the Republic Veteran kerchief. Special Collections and College Archives Finding Aids are discovery tools used to describe and provide access to our holdings. Finding aids include historical and biographical information about each collection in addition to inventories of their content. More information about our collections can be found on our website http://www.gettysburg.edu/special?collections/collections/.”https://cupola.gettysburg.edu/findingaidsall/1160/thumbnail.jp

    Differential regulation of innate and adaptive immune responses in viral encephalitis.

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    Viral encephalitis is a global health concern. The ability of a virus to modulate the immune response can have a pivotal effect on the course of disease and the fate of the infected host. In this study, we sought to understand the immunological basis for the fatal encephalitis following infection with the murine coronavirus, mouse hepatitis virus (MHV)-JHM, in contrast with the more attenuated MHV-A59. Distinct glial cell cytokine and chemokine response patterns were observed within 3 days after infection, became progressively more polarized during the course of infection and with the infiltration of leukocytes. In the brain, MHV-JHM infection induced strong accumulation of IFNbeta mRNA relative to IFNgamma mRNA. This trend was reversed in MHV-A59 infection and was accompanied by increased CD8 T cell infiltration into brain compared to MHV-JHM infection. Increased apoptosis appeared to contribute to the diminished presence of CD8 T cells in MHV-JHM-infected brain with the consequence of a lower potential for IFNgamma production and antiviral activity. MHV-JHM infection also induced sustained mRNA accumulation of the innate immune response products interleukin (IL)-6 and IL-1. Furthermore, high levels of macrophage-inflammatory protein (MIP)-1alpha, MIP-1beta, and MIP-2 mRNA were observed at the onset of MHV-JHM infection and correlated with a marked elevation in the number of macrophages in the brain on day 7 compared to MHV-A59 infection. These observations indicate that differences in the severity of viral encephalitis may reflect the differential ability of viruses to stimulate innate immune responses within the CNS and subsequently the character of infiltrating leukocyte populations
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