Scatter plot showing the relationship between serum ANGPTL2 levels and other clinical parameters.

<p>ANGPTL2 levels were positively correlated with hsCRP, TNF-α, A-FABP, NT-proBNP, and negatively correlated with eGFR and LVEF. (The Spearman correlation coefficients rho are presented).</p

The receiver operating characteristic (ROC) curve of serum ANGPTL2 levels for the identification of patients with heart failure.

<p>The receiver operating characteristic (ROC) curve of serum ANGPTL2 levels for the identification of patients with heart failure.</p

Characteristics of patients with heart failure and controls.

<p>ANGPTL2, angiopoietin-like protein 2; A-FABP, adipocyte fatty acid-binding protein; ACEi/ARB, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers; CAD, coronary artery disease; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c; hsCRP, high-sensitivity C-reactive protein; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; LAd, left atrial dimension; LVEDd, left ventricular end-diastolic dimension; LVESd, left ventricular end-systolic dimension; LVEF, left ventricular ejection fraction; NT-proBNP, N-terminal pro-brain natriuretic peptide; TNF-α, tumor necrosis factor alpha.</p><p>* Presented with median (25^th to 75^th percentile) and analyzed by the Mann-Whitney U test</p><p># Hyperlipidemia is defined as total cholesterol ≥ 240mg/dl, triglyceride ≥ 200mg/dl, or current use of lipid-lowering medication</p><p>Characteristics of patients with heart failure and controls.</p

Multiple stepwise regression analysis showing the variables independently associated with the serum level of ANGPTL2.

<p>Variables included in the original model are age, gender, fasting glucose, HbA1c, triglyceride, HDL-C, creatinine, hsCRP, TNF-α, A-FABP, and NT-proBNP</p><p>* ANGPTL2, triglyceride, hsCRP, A-FABP, TNF-α, and NT-proBNP are logarithmically transformed before analysis.</p><p>Multiple stepwise regression analysis showing the variables independently associated with the serum level of ANGPTL2.</p

Spearman correlation of ANGPTL2 levels with cardiovascular risk factors.

<p>Spearman correlation of ANGPTL2 levels with cardiovascular risk factors.</p

Multivariate logistic regression analyses showing the odds ratios (OR) for the presence of heart failure in different levels of circulating ANGPTL2.

<p>Lowest tertile: ANGPTL2 level ≤3.4 ng/mL; middle tertile: 3.4 ng/mL< ANGPTL2 level ≤ 4.8 ng/mL; highest tertile: ANGPTL2 level >4.8 ng/mL</p><p>Model 1 adjusted for age and gender</p><p>Model 2 adjusted for age, gender, body-mass index, diabetes, hyperlipidemia, fasting glucose, creatinine, hsCRP, TNF-α, adiponectin, NT-proBNP, and diagnosis of CAD</p><p>Multivariate logistic regression analyses showing the odds ratios (OR) for the presence of heart failure in different levels of circulating ANGPTL2.</p

Incidence of acute coronary syndrome by prescriptions.

<p>Incidence of acute coronary syndrome by prescriptions.</p

Patient flow diagram.

<p>Patient flow diagram.</p

Subgroup analyses.

<p><b>A</b>. Hazard ratios of myocardial infarction (MI) in specific subgroups of sulfonylureas treated patients by using insulin as reference group. <b>B</b>. Hazard ratios of MI in specific subgroups of meglitinides treated patients by using insulin as reference group. <b>C</b>. Hazard ratios of MI in specific subgroups of TZD treated patients by using insulin as reference group. Abbreviations: CI, confidence interval; CVD, cardiovascular disease (combination of coronary artery disease, ischemic stroke, hemorrhagic stroke, peripheral artery disease); CHF, congestive heart failure; HTN, hypertension; HR, hazard ratio; TZD, thiazolidinedione.</p

Demographic and clinical characteristics of study subjects.

<p>Demographic and clinical characteristics of study subjects.</p