The Ursinus Weekly, February 14, 1974

Week-long festival of arts slated to begin February 22 • Ursinus, at mid-winter, continues coping with problems of energy conservation • Forums set for semester • ProTheatre to present evening of avant-garde • Villanova University to sponsor tenth law review symposium • Editorial: The Myrin follies; Situation wanted: Hero • First semester Dean’s List • Letters to the editor: Union anniversary; Madison Avenue\u27s effect • Student teachers respond to experiences in area schools • SFARC News • Film Review: The Exorcist • Alumni Corner: Mike Hunter: Society drop-in • De-horn the Rams! • Jazz: Thad Jones, Mel Lewis • USGA holds elections, makes amendments and forms committees • 9-5 and still alive!https://digitalcommons.ursinus.edu/weekly/1009/thumbnail.jp

Casting a wider net: Immunosurveillance by nonclassical MHC molecules

Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a wide variety of nonclassical MHC molecules. These include αβ and γδ T cells that recognize different class Ib molecules (CD1, MR-1, HLA-E, G, F, et al.) that are nearly monomorphic within a given species. Collectively, these T cells can be considered “unconventional,” in part because they recognize lipids, metabolites, and modified peptides. Unlike classical MHC-specific cells, unconventional T cells generally exhibit limited T-cell antigen receptor (TCR) repertoires and often produce innate immune cell-like rapid effector responses. Exploiting this system in new generation vaccines for human immunodeficiency virus (HIV), tuberculosis (TB), other infectious agents, and cancer was the focus of a recent workshop, “Immune Surveillance by Non-classical MHC Molecules: Improving Diversity for Antigens,” sponsored by the National Institute of Allergy and Infectious Diseases. Here, we summarize salient points presented regarding the basic immunobiology of unconventional T cells, recent advances in methodologies to measure unconventional T-cell activity in diseases, and approaches to harness their considerable clinical potential

Multilingual markers of depression in remotely collected speech samples: A preliminary analysis

Background: Speech contains neuromuscular, physiological and cognitive components, and so is a potential biomarker of mental disorders. Previous studies indicate that speaking rate and pausing are associated with major depressive disorder (MDD). However, results are inconclusive as many studies are small and underpowered and do not include clinical samples. These studies have also been unilingual and use speech collected in controlled settings. If speech markers are to help understand the onset and progress of MDD, we need to uncover markers that are robust to language and establish the strength of associations in real-world data. // Methods: We collected speech data in 585 participants with a history of MDD in the United Kingdom, Spain, and Netherlands as part of the RADAR-MDD study. Participants recorded their speech via smartphones every two weeks for 18 months. Linear mixed models were used to estimate the strength of specific markers of depression from a set of 28 speech features. // Results: Increased depressive symptoms were associated with speech rate, articulation rate and intensity of speech elicited from a scripted task. These features had consistently stronger effect sizes than pauses. // Limitations: Our findings are derived at the cohort level so may have limited impact on identifying intra-individual speech changes associated with changes in symptom severity. The analysis of features averaged over the entire recording may have underestimated the importance of some features. // Conclusions: Participants with more severe depressive symptoms spoke more slowly and quietly. Our findings are from a real-world, multilingual, clinical dataset so represent a step-change in the usefulness of speech as a digital phenotype of MDD

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely

Five-Phase Approach to Improve Design of Printed Transit Information and to Monitor Impact on Customer Satisfaction

Transfort, the transit service provider in Fort Collins, Colorado, conducted a major design overhaul of its printed information materials (system maps, route maps, and schedules) to achieve the following objectives: (a) increase user comprehension of printed materials, (b) increase ridership, and (c) reduce printing costs while adding four additional routes to the schedule book. To achieve those objectives, a five-phase process was developed to allow the redesign task to be informed by research literature, transit staff opinions, and the views of service users. The new designs were implemented incrementally between July 2007 and August 2008 and were accompanied by a marketing campaign that informed and explained the upcoming changes. Ongoing project monitoring efforts indicated high levels of customer satisfaction with the revised materials and their new features and significant cost savings of 26%, as well as some evidence of a positive ridership effect. These outcomes provide an endorsement of the five-phase approach developed by Transfort and suggest that it may be useful to other transit agencies considering a major revision of their printed information materials

The control of manual skills in children with Down syndrome

It is widely accepted that individuals with Down syndrome (DS) experience difficulty performing motor skills. The impact of these performance difficulties is widespread, affecting achievement in academic settings in tasks such as writing and using a keyboard, and compromising efficiency in employment and recreational opportunities. One of the strong motivations for our program of research on motor behavior in children with DS is the maximization of participation of individuals in school, home, and community life. Our work has been concerned with everyday manipulative skills and their adaptive performance under different contextual conditions, which, arguably, are critical for achieving independence and full participation in all aspects of life. This work has explored the fundamental nature of movement difficulties in DS within the framework of a Coordinated Control Program for reach-to-grasp actions (Arbib, 1981; Hoff & Arbib, 1993) and has been guided by current research describing the kinematic characteristics and neurological correlates of upper-limb control in prehension (Jeannerod, 1981, 1984, 1997; Jeannerod & Rosetti, 1993). Later in this chapter we introduce the model of coordinated control for reaching and grasping and describe its application to the study of motor difficulties in DS. First, we provide a brief overview of development across a number of domains, highlighting the nature of the developmental path, areas of atypicality, and the influence of multiple constraints on motor performance in individuals with DS

Comparison of atovaquone (566C80) with trimethoprim-sulfamethoxazole to treat Pneumocystis Carinii pneumonia in patients with aids

Background. Both trimethoprim-sulfamethoxazole and pentamidine are effective as treatments for Pneumocystis carinii pneumonia, but adverse effects frequently limit their use. Atovaquone (566C80) is a new hydroxynaphthoquinone with activity against P. carinii. Methods. We conducted a double-blind, multicenter study in patients with the acquired immunodeficiency syndrome and mild or moderately severe P. carinii pneumonia. They were randomly assigned to 21 days of orally administered treatment three times daily with either atovaquone (750 mg) or trimethoprim (320 mg) plus sulfamethoxazole (1600 mg). Results. Of the 322 patients with histologically confirmed P. carinii pneumonia, 160 received atovaquone and 162 received trimethoprim-sulfamethoxazole. Of those who could be evaluated for therapeutic efficacy, 28 of 138 patients given atovaquone (20 percent) and 10 of 146 patients given trimethoprim-sulfamethoxazole (7 percent) did not respond (P = 0.002). Treatment-limiting adverse effects required a change of therapy in 11 patients in the atovaquone group (7 percent) and 33 patients in the trimethoprim-sulfamethoxazole group (20 percent) (P = 0.001), Therapy involving only the initial drug was successful and free of adverse effects in 62 percent of those assigned to atovaquone and 64 percent of those assigned to trimethoprim-sulfamethoxazole. Within four weeks of the completion of treatment, there were 11 deaths in the atovaquone group (4 due to P. carinii pneumonia) and 1 death in the trimethoprim-sulfamethoxazole group (P = 0.003). Diarrhea at entry was associated with lower plasma drug concentrations (P = 0.009), therapeutic failure (P<0.001), and death (P<0.001 ) in the atovaquone group but not in the trimethoprim-sulfamethoxazole group. Conclusions. For the treatment of P. carinii pneumonia, atovaquone is less effective than trimethoprim-sulfamethoxazole, but it has fewer treatment-limiting adverse effects.SCOPUS: re.jinfo:eu-repo/semantics/publishe

Multilingual markers of depression in remotely collected speech samples: a preliminary analysis

BackgroundSpeech contains neuromuscular, physiological and cognitive components, and so is a potential biomarker of mental disorders. Previous studies indicate that speaking rate and pausing are associated with major depressive disorder (MDD). However, results are inconclusive as many studies are small and underpowered and do not include clinical samples. These studies have also been unilingual and use speech collected in controlled settings. If speech markers are to help understand the onset and progress of MDD, we need to uncover markers that are robust to language and establish the strength of associations in real-world data.MethodsWe collected speech data in 585 participants with a history of MDD in the United Kingdom, Spain, and Netherlands as part of the RADAR-MDD study. Participants recorded their speech via smartphones every two weeks for 18 months. Linear mixed models were used to estimate the strength of specific markers of depression from a set of 28 speech features.ResultsIncreased depressive symptoms were associated with speech rate, articulation rate and intensity of speech elicited from a scripted task. These features had consistently stronger effect sizes than pauses.LimitationsOur findings are derived at the cohort level so may have limited impact on identifying intra-individual speech changes associated with changes in symptom severity. The analysis of features averaged over the entire recording may have underestimated the importance of some features.ConclusionsParticipants with more severe depressive symptoms spoke more slowly and quietly. Our findings are from a real-world, multilingual, clinical dataset so represent a step-change in the usefulness of speech as a digital phenotype of MDD.</p