Annotations are provided to the Gene Ontology Consortium as tab-delimited files with 15 fields

Four fields indicate the gene product being annotated, the ontology terms used in the association, the type of evidence supporting the annotation and the reference where the original evidence was presented. The three annotations described in this manuscript are shown.<p><b>Copyright information:</b></p><p>Taken from "Gene Ontology annotations: what they mean and where they come from"</p><p>http://www.biomedcentral.com/1471-2105/9/S5/S2</p><p>BMC Bioinformatics 2008;9(Suppl 5):S2-S2.</p><p>Published online 29 Apr 2008</p><p>PMCID:PMC2367625.</p><p></p

Distribution of GO terms at several precision/recall performance points

Proportion of Gene Ontology (GO) terms per evaluation category with a precision/recall performance point that is both above and to the right of a given precision/recall point in the contour plots. GO-BP, GO Biological process; GO-CC, GO Cellular component; GO-MF, GO Molecular function.<p><b>Copyright information:</b></p><p>Taken from "A critical assessment of gene function prediction using integrated genomic evidence"</p><p>http://genomebiology.com/2008/9/S1/S2</p><p>Genome Biology 2008;9(Suppl 1):S2-S2.</p><p>Published online 27 Jun 2008</p><p>PMCID:PMC2447536.</p><p></p

Illustration of evidence underlying predictions for the GO term 'Mitochondrial part'

As described in Figure 6a-e. GO, Gene Ontology.<p><b>Copyright information:</b></p><p>Taken from "A critical assessment of gene function prediction using integrated genomic evidence"</p><p>http://genomebiology.com/2008/9/S1/S2</p><p>Genome Biology 2008;9(Suppl 1):S2-S2.</p><p>Published online 27 Jun 2008</p><p>PMCID:PMC2447536.</p><p></p

Illustration of evidence underlying predictions for the GO term 'Cell adhesion'

As an assessment of predictive usefulness, the precision at 20% recall (P20R) value based on each single data source is shown in parentheses. Expression levels of annotated genes (dark green) and predictions (orange), grouped by Pearson correlation and complete-linkage hierarchical clustering. Protein domains in common among predictions and annotated genes. Largest protein-protein interaction network among predictions and annotated genes. OPHID, Online Predicted Human Interaction Database. Disease and phenotype annotations in common between predictions and annotated genes. Terminal digits of identifiers are shown in parentheses. OMIM, Online Mendelian Inheritance in Man.<p><b>Copyright information:</b></p><p>Taken from "A critical assessment of gene function prediction using integrated genomic evidence"</p><p>http://genomebiology.com/2008/9/S1/S2</p><p>Genome Biology 2008;9(Suppl 1):S2-S2.</p><p>Published online 27 Jun 2008</p><p>PMCID:PMC2447536.</p><p></p