Internet of Things (IoT) Payload in IRIS CubeSat

IRIS-A is one of CubeSats in IRIS project which is designed, and still developing by NCKU, Taiwan. The mission objective of it is to demonstrate Internet of Things (IoT) communication technology in space. Techniques are developed to compensate for the significant attenuation and Doppler shift in the mission so that ground measurements can be uplinked, stored, and forwarded. To achieve this, there would need the following devices to cooperate in IoT payload, including the LoRa receiver, a reference clockboard, a chip-scale atomic clock (CSAC) and a GPS receiver (GPSR)

Flight Software Implementation and Verification on IRIS CubeSat

Flight software (FSW) is essential in the operation of a satellite program. It is important to verify the functionality and performance of the FSW on ground before being deployed in space. We discusses the implementation and verification of the FSW of the Intelligent Remote-Sensing and Internet Satellite (IRIS) CubeSats

Analysis of Tumbling Motions by Combining Telemetry Data and Radio Signal

The pointing accuracy and stabilization property of the payload of a satellite depends on performance of attitude determination and control system (ADCS). An essential role of the ADCS is to stabilize the spacecraft in early operation stage and in the presence of anomalies. During this stage, the satellite may be subject to tumbling and a high-reliability method is deemed important to recover the satellite from this stage into its normal operation stage. In the paper, the use of magnetometer data and radio signal characteristics is investigated with the goal of determining the satellite tumbling rate confidently. The proposed method is applied to the PHOENIX CubeSat, which is a CubeSat that is developed by National Cheng Kung University, Taiwan as a part of the QB50 project, at its early orbit stage

Impact of Ancestral Differences and Reassessment of the Classification of Previously Reported Pathogenic Variants in Patients With Brugada Syndrome in the Genomic Era: A SADS-TW BrS Registry

Brugada syndrome (BrS) is a heritable disease that results in sudden cardiac death. In the exome/genomic era, certain reported pathogenic variants in some genetic diseases have been reclassified as benign owing to their high frequency in some ancestries. In the present study, we comprehensively reassessed all previously reported pathogenic variants of BrS. We collected all pathogenic variants of BrS reported in the Human Gene Mutation Database and ClinVar throughout April 2017. We compared the minor allele frequency (MAF) of each variant among different ancestries by searching public whole-genome and exome databases. After considering the maximum credible allele frequency, variants with a MAF ≥ 0.001 were considered to be of questionable pathogenicity. We also investigated the percentage of SCN5A variants with a MAF ≥ 0.001 in 124 BrS patients from the Han Chinese population. We collected a total of 440 BrS variants, of which 18 had a MAF ≥ 0.001. There was a greater percentage of non-SCN5A variants with a MAF ≥ 0.001 than of SCN5A variants (21.8 versus 1.6%, p < 0.0001). There were fewer frameshift and nonsense mutations than missense mutations (0.9 versus 5.6%, p = 0.032). Of the 18 variants, 14 (77.8%) were present only in the reference Asian population. In our cohort, we identified two SCN5A variants (p.A226V and p.V1340I) with MAFs ≥ 0.001 (0.45%). In conclusion, ancestral differences are important when considering the pathogenicity of BrS variants, especially in the case of missense variants and non-SCN5A variants, which may be pathogenic in some ancestries but only disease-predisposing in others

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels

Large-scale meta-analyses of genome-wide association studies (GWAS) have identified >175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). With differences in linkage disequilibrium (LD) structure and allele frequencies between ancestry groups, studies in additional large samples may detect new associations. We conducted staged GWAS meta-analyses in up to 69,414 East Asian individuals from 24 studies with participants from Japan, the Philippines, Korea, China, Singapore, and Taiwan. These meta-analyses identified (P < 5 × 10-8) three novel loci associated with HDL-C near CD163-APOBEC1 (P = 7.4 × 10-9), NCOA2 (P = 1.6 × 10-8), and NID2-PTGDR (P = 4.2 × 10-8), and one novel locus associated with TG near WDR11-FGFR2 (P = 2.7 × 10-10). Conditional analyses identified a second signal near CD163-APOBEC1. We then combined results from the East Asian meta-analysis with association results from up to 187,365 European individuals from the Global Lipids Genetics Consortium in a trans-ancestry meta-analysis. This analysis identified (log10Bayes Factor ≥6.1) eight additional novel lipid loci. Among the twelve total loci identified, the index variants at eight loci have demonstrated at least nominal significance with other metabolic traits in prior studies, and two loci exhibited coincident eQTLs (P < 1 × 10-5) in subcutaneous adipose tissue for BPTF and PDGFC. Taken together, these analyses identified multiple novel lipid loci, providing new potential therapeutic targets

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488–47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10−13), ALDH2/MYL2 (rs671, P = 3.40 × 10−11; rs12229654, P = 4.56 × 10−9), ITIH4 (rs2535633, P = 1.77 × 10−10) and NT5C2 (rs11191580, P = 3.83 × 10−8) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10−8) and an additional 14 at P < 1.0 × 10−3 with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity

Estimation of Lane-Level Traffic Flow Using a Deep Learning Technique

This paper proposes a neural network that fuses the data received from a camera system on a gantry to detect moving objects and calculate the relative position and velocity of the vehicles traveling on a freeway. This information is used to estimate the traffic flow. To estimate the traffic flows at both microscopic and macroscopic levels, this paper used YOLO v4 and DeepSORT for vehicle detection and tracking. The number of vehicles passing on the freeway was then calculated by drawing virtual lines and hot zones. The velocity of each vehicle was also recorded. The information can be passed to the traffic control center in order to monitor and control the traffic flows on freeways and analyze freeway conditions

Retrieval of Ocean Surface Wind Speed Using Reflected BPSK/BOC Signals

The Global Navigation Satellite System (GNSS) has become a valuable resource as a remote sensing technique. In the past decade, the use of reflected GNSS signals for sensing the Earth, also known as GNSS reflectometry (GNSS-R), has grown rapidly. On the other hand, with the continuous development of GNSS, multi-frequency multi-modulation signals have been used to enhance not only positioning performance, but also remote sensing applications. It is known that for some constellations, navigation satellites broadcast signals employing BPSK (binary phase-shift keying) modulation and BOC (binary offset carrier) modulation at the same frequency band. This paper proposes a new GNSS-R measurement, called a composite delay-Doppler map (cDDM), by utilizing the received reflected GNSS signals with different modulation techniques for the purpose of retrieving wind speed. The GNSS-R receiver can receive BPSK and BOC signals simultaneously at the same frequency band (e.g., GPS III L1 C/A and L1C or QZSS L1 C/A and L1C) and process the signals to generate GNSS-R measurements. Exploration of the observable features extracted from the composite DDM and the wind speed retrieval algorithm are also provided. The simulation verifies the proposed method under a configuration that is specified for the orbital and instrument specification of the upcoming TRITON mission