1 research outputs found
New triterpenoids from the aerial parts of the Uygur medicine <i>Salvia deserta</i>
Phytochemical investigation on the aerial parts of Salvia deserta led to the isolation of eight new pentacyclic triterpenoids including three oleanane- (1βββ3) and five ursane-type (4βββ8) triterpenoids, whose structures were elucidated based on extensive spectroscopic analysis and quantum chemical calculation. Weak immunosuppressive potency was observed for compounds 1, 2, and 4βββ8 via inhibiting the secretion of cytokines TNF-Ξ± and IL-6 in LPS-induced macrophages RAW264.7 at 20βΞΌM. In addition, compounds 1, 2, and 4βββ6 exhibited moderate protective activity on t-BHP-induced oxidative injury in HepG2 cells.</p