DataSheet_1_Efficacy and safety of anakinra and canakinumab in PSTPIP1-associated inflammatory diseases: a comprehensive scoping review.pdf

IntroductionThis scoping review explores the effectiveness of IL-1 pathway inhibitors in managing PSTPIP1-associated inflammatory diseases (PAID). These diseases are marked by abnormal IL-1 pathway activation due to genetic mutations.MethodsOur methodology adhered to a pre-published protocol and involved a thorough search of MEDLINE and EMBASE databases up to February 2022, following the Joanna Briggs Institute Reviewer’s Manual and the PRISMA Extension for Scoping Reviews. The review included studies reporting on IL-1 pathway inhibitor use in PAID patients.ResultsFrom an initial pool of 5,225 articles, 36 studies involving 43 patients were selected. The studies predominantly used observational designs and exhibited diversity in patient demographics, treatment approaches, and outcomes. Anakinra and canakinumab demonstrated promise in treating sterile pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) and PSTPIP1-associated myeloid-related-proteinemia inflammatory (PAMI) syndromes, with scant data on other syndromes. Notably, there was a paucity of information on the adverse effects of these treatments, necessitating cautious interpretation of their safety profile.ConclusionCurrent evidence on IL-1 pathway inhibitors for PAID is primarily from observational studies and remains limited. Rigorous research with larger patient cohorts is imperative for more definitive conclusions. Collaborative efforts among specialized research centers and international health initiatives are key to advancing this field.</p

Author-paper affiliation network architecture influences the methodological quality of systematic reviews and meta-analyses of psoriasis

<div><p>Moderate-to-severe psoriasis is associated with significant comorbidity, an impaired quality of life, and increased medical costs, including those associated with treatments. Systematic reviews (SRs) and meta-analyses (MAs) of randomized clinical trials are considered two of the best approaches to the summarization of high-quality evidence. However, methodological bias can reduce the validity of conclusions from these types of studies and subsequently impair the quality of decision making. As co-authorship is among the most well-documented forms of research collaboration, the present study aimed to explore whether authors’ collaboration methods might influence the methodological quality of SRs and MAs of psoriasis. Methodological quality was assessed by two raters who extracted information from full articles. After calculating total and per-item Assessment of Multiple Systematic Reviews (AMSTAR) scores, reviews were classified as low (0-4), medium (5-8), or high (9-11) quality. Article metadata and journal-related bibliometric indices were also obtained. A total of 741 authors from 520 different institutions and 32 countries published 220 reviews that were classified as high (17.2%), moderate (55%), or low (27.7%) methodological quality. The high methodological quality subnetwork was larger but had a lower connection density than the low and moderate methodological quality subnetworks; specifically, the former contained relatively fewer nodes (authors and reviews), reviews by authors, and collaborators per author. Furthermore, the high methodological quality subnetwork was highly compartmentalized, with several modules representing few poorly interconnected communities. In conclusion, structural differences in author-paper affiliation network may influence the methodological quality of SRs and MAs on psoriasis. As the author-paper affiliation network structure affects study quality in this research field, authors who maintain an appropriate balance between scientific quality and productivity are more likely to develop higher quality reviews.</p></div

Summary statistics for the co-authorship networks based on methodology quality.

<p>Summary statistics for the co-authorship networks based on methodology quality.</p

Whole author-paper affiliation network.

<p>(a). Nodes that represent authors are colored and labeled based on their institution’s country. Grey nodes represent the reviews on psoriasis which were finally included. Node size is proportional to the author’s H-index or AMSTAR score respectively. Edges connect both types of nodes, thus every author and their collaborators are linked to the shared publication. (b). Same network, although only nodes representing articles are colored based on AMSTAR levels.</p

Gilberte. Bouffes. Mam'zelle Crénom : [photographie, tirage de démonstration] / [Atelier Nadar]

Appendix 5. Phase 2 domains and signaling questions of ROBIS tool. (DOC 32 kb

Influence of authors’ scientific quality and productivity on methodological quality of SRs and MAs about psoriasis.

<p>Panel (a-c): Bubble plot that represents the number of publications by author. Bubble size is proportional to the author’s H-index. Authors are sorted by their institution’s country. Panel (d-f) represents a scatter plot of author’s H-index vs. number of authored publications. Smoothed fitted lines represent predictions using linear regression for every country. Points and lines are colored based on author institution country.</p

Author-paper affiliation subnetworks based on methodological quality of the reviews.

<p>Nodes that represent authors are colored and labeled based on their institution’s country. Grey nodes represent the SRs and MAs on psoriasis which were finally included. Node size is proportional to the author’s H-index or AMSTAR score respectively. Edges connect both types of nodes, thus every author and their collaborators are connected to the shared publication.</p

Cumulative frequency of node degree distributions.

<p>The cumulative node degree distribution shows the cumulative number of nodes of each degree class. The distribution of degree values over all nodes characterizes the network as a whole.</p