6,321 research outputs found

    Electroweak corrections to WWZ and ZZZ production at the linear collider

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    We calculate the electroweak corrections to the production of WWZ and ZZZ at the linear collider in the Standard Model. These processes are important for the extraction of the quartic couplings of the massive gauge bosons which can be a window on the mechanism of spontaneous symmetry breaking. We find that the weak corrections to some kinematic distributions show new features and hence cannot be explained by an overall scale factor.Comment: 5 pages, 2 figs, contribution to the Corfu 2009 proceeding

    Reprogramming of 3′ Untranslated Regions of mRNAs by Alternative Polyadenylation in Generation of Pluripotent Stem Cells from Different Cell Types

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    The 3' untranslated regions (3'UTRs) of mRNAs contain cis elements involved in post-transcriptional regulation of gene expression. Over half of all mammalian genes contain multiple polyadenylation sites that lead to different 3'UTRs for a gene. Studies have shown that the alternative polyadenylation (APA) pattern varies across tissues, and is dynamically regulated in proliferating or differentiating cells. Generation of induced pluripotent stem (iPS) cells, in which differentiated cells are reprogrammed to an embryonic stem (ES) cell-like state, has been intensively studied in recent years. However, it is not known how 3'UTRs are regulated during cell reprogramming.Using a computational method that robustly examines APA across DNA microarray data sets, we analyzed 3'UTR dynamics in generation of iPS cells from different cell types. We found that 3'UTRs shorten during reprogramming of somatic cells, the extent of which depends on the type of source cell. By contrast, reprogramming of spermatogonial cells involves 3'UTR lengthening. The alternative polyadenylation sites that are highly responsive to change of cell state in generation of iPS cells are also highly regulated during embryonic development in opposite directions. Compared with other sites, they are more conserved, can lead to longer alternative 3'UTRs, and are associated with more cis elements for polyadenylation. Consistently, reprogramming of somatic cells and germ cells involves significant upregulation and downregulation, respectively, of mRNAs encoding polyadenylation factors, and RNA processing is one of the most significantly regulated biological processes during cell reprogramming. Furthermore, genes containing target sites of ES cell-specific microRNAs (miRNAs) in different portions of 3'UTR are distinctively regulated during cell reprogramming, suggesting impact of APA on miRNA targeting.Taken together, these findings indicate that reprogramming of 3'UTRs by APA, which result from regulation of both general polyadenylation activity and cell type-specific factors and can reset post-transcriptional gene regulatory programs in the cell, is an integral part of iPS cell generation, and the APA pattern can be a good biomarker for cell type and state, useful for sample classification. The results also suggest that perturbation of the mRNA polyadenylation machinery or RNA processing activity may facilitate generation of iPS cells

    Function Analysis of Industrial Robot under Cubic Polynomial Interpolation in Animation Simulation Environment

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    In order to study the effect of cubic polynomial interpolation in the trajectory planning of polishing robot manipulator, firstly, the articular robot operating arm is taken as the research object, and the overall system of polishing robot operating arm with 7 degrees of freedom is constructed. Then through the transformation of space motion and pose coordinate system, Denavit-Hartenberg (D-H) Matrix is introduced to describe the coordinate direction and parameters of the adjacent connecting rod of the polishing robot, and the kinematic model of the robot is built, and the coordinate direction and parameters of its adjacent link are described. A multi-body Dynamic simulation software, Automatic Dynamic Analysis of Mechanical Systems (ADAMS), is used to analyze the kinematic simulation of the robot operating arm system. Finally, the trajectory of the robot manipulator is planned based on the cubic polynomial difference method, and the simulation is verified by Matrix Laboratory (MATLAB). Through calculation, it is found that the kinematic model of polishing robot operating arm constructed in this study is in line with the reality; ADAMS software is used to generate curves of the rotation angles of different joint axes and the displacement of end parts of the polishing robot operating arm changing with time. After obtaining relevant parameters, they are put into the kinematic equation constructed in this study, and the calculated position coordinates are consistent with the detection results; moreover, the polishing robot constructed in this study can realize the functions of deburring, polishing, trimming, and turning table. MATLAB software is used to generate the simulation of the movement trajectory of the polishing robot operating arm, which can show the change curve of angle and angular velocity. The difference between the angle at which the polishing robot reaches the polishing position, the change curve of angular velocity, and the time spent before and after the path optimization is compared. It is found that after path optimization based on cubic polynomial, the change curve of the polishing robot's angle and angular velocity is smoother, and the time is shortened by 17.21s. It indicates that the cubic polynomial interpolation method can realize the trajectory planning of the polishing robot operating arm, moreover, the optimized polishing robot has a continuous and smooth trajectory, which can improve the working efficiency of the robot

    Selection of Programming Language in the Development of Computer Application Software

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    Research showed that the popularization of the Internet among people can be attributed to recent years’ continuous development of science and technology, making it an important part of people’s daily life. Researcher showed that, for the better development of software application, the related staff should throw themselves actively into the appropriate selection and application of programming language. The variety of the programming languages in network system have imposed a restriction on the optimization of programmers’ level, as a result, developers often find it difficult to effectively implement the application of relevant programming languages. The appropriate management of this problem requires active analysis of the various programming languages, and it also has becoming an important issue in the development of China’s Internet industry. Aiming at promote the level of computer software development. This article explored the programming language selection under the process of computer application software development

    Psychosocial factors underlying physical activity

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    © 2007 Zhang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

    Fuzzy Filter Spectrum of a BCK Algebra

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    The notion of fuzzy s-prime filters of a bounded BCK-algebra is introduced. We discuss the relation between fuzzy s-prime filters and fuzzy prime filters. By the fuzzy s-prime filters of a bounded commutative BCK-algebra X, we establish a fuzzy topological structure on X. We prove that the set of all fuzzy s-prime filters of a bounded commutative BCK-algebra forms a topological space. Moreover, we show that the set of all fuzzy s-prime filters of a bounded implicative BCK-algebra is a Hausdorff space
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