Functional impacts of <i>FTO</i> and <i>SH2B1</i> rare non-synonymous mutations.

<p>PROVEAN: Protein Variation Effect Analyzer; SIFT: Sorts Intolerant From Tolerant; Polyphen-2: Polymorphism Phenotyping v2.</p

The anthropological characteristics of children with early-onset obesity and lean control.

<p>Data are means±SD unless otherwise indicated.</p

Prevalence of rare non-synonymous mutations in <i>FTO</i> in obese and lean children.

<p>Rare non-synonymous mutations denote variations with frequency<0.01.</p

Distribution of rare non-synonymous variants along FTO functional domains.

<p>FTO protein is consisted of a N-terminal domain (NTD, residue 32–326) and a C-terminal domain (CTD, residue 327–505). Different non-synonymous mutations with frequency in parenthesis were presented both for obese children and control population.</p

Difference on prevalence of <i>FTO</i> rare non-synonymous mutation between boys and girls with obesity.

<p>Difference on prevalence of <i>FTO</i> rare non-synonymous mutation between boys and girls with obesity.</p

Prevalence of <i>FTO</i> and <i>SH2B1</i> rare non-synonymous mutations in different populations.

<p>ESP: NHLBI Exome Sequencing Project; CHC: Chinese Han children; FC/EC: French children/English children from Meyre's cohort <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067039#pone.0067039-Ren2" target="_blank">[22]</a>; EA: European American; AA: African American.</p