Performance of ImCUSS, SAPS II and SAPS 3.

<p>* SMR: Standardized Mortality Ratio.</p><p>^₸ GOF: Goodness-Of-Fit.</p><p>³ AUROC: Area Under Receiver Operating Characteristic Curve</p><p>¹ Performance in the validation cohort (n = 189).</p><p>² Performance in the whole cohort (n = 743).</p><p>Performance of ImCUSS, SAPS II and SAPS 3.</p

Patient characteristics and complementary data.

<p>* All the remaining variables including diabetes, dyslipidemia, heart failure, previous coronary heart disease, heart arrhythmia, neurologic illness, body mass index, temperature, pH, sodium, potassium, magnesium and GPT were not statistically significant. Some variables described as continuous were also studied as polychotomous and dichotomous ones.</p><p>¹ ICU: Intensive Care Unit.</p><p>² COPD: Chronic Obstructive Pulmonary Disease.</p><p>³ BP: Blood Pressure.</p><p>⁴ NIV: Non-invasive Ventilation.</p><p>⁵ ESRD: End-Stage Renal Disease.</p><p>⁶ SBP: Systolic Blood Pressure.</p><p>⁷ ImCU: Intermediate Care Unit.</p><p>Patient characteristics and complementary data.</p

ImCUSS receiver operating characteristic curve (ROC) for mortality in the validation cohort (n = 189).

<p>ImCUSS receiver operating characteristic curve (ROC) for mortality in the validation cohort (n = 189).</p

Mortality prediction model—using maximum likelihood estimation logistic regression.

<p>* SE: Standard Error</p><p>^₸ OR: Odds Ratio</p><p>³ CI: Confidence Interval</p><p>¹ NIV: Non-invasive ventilation</p><p>Mortality prediction model—using maximum likelihood estimation logistic regression.</p

Receiver Operating Characteristic curves in the different prognostic models.

<p>(A) SAPS II and SAPS II-CNIV. (B) SAPS 3 and SAPS 3-CNIV.</p

Clinical application of SAPS 3-CNIV: Death probability according to customized scores.

<p>Clinical application of SAPS 3-CNIV: Death probability according to customized scores.</p

Patient characteristics.

<p>Values are expressed as mean (standard deviation), unless otherwise stated.</p><p>SD: Standard deviation; COPD: chronic obstructive pulmonary disease; ICU: Intensive care unit; ImCU: Intermediate care unit; BP: Blood pressure; C-RP: C-reactive protein</p><p>*Immunosuppression as described in SAPS 3: Use of chemotherapy, radiotherapy, immunosuppressive drugs or corticosteroids in the last 6 months</p><p>Patient characteristics.</p

Logistic regression and score customization for SAPS II.

<p>*Immunosuppression as described in SAPS 3: Use of chemotherapy, radiotherapy, immunosuppressive drugs or corticosteroids in the last 6 months</p><p>Logistic regression and score customization for SAPS II.</p

Univariate analysis of new variables for NIV mortality prediction.

<p>Values are expressed as mean (standard deviation), unless otherwise stated.</p><p>*COPD/hypoxemic ARF/APE/Neuromuscular disease</p><p>^†p of comparison between subgroups was calculated with t-Student and chi square tests</p><p>Univariate analysis of new variables for NIV mortality prediction.</p

Logistic regression and score customization for SAPS 3.

<p>Logistic regression and score customization for SAPS 3.</p