Predicate-logic-based representation of semantic relationships between goals and problems

El mundo organizacional siempre tendrá objetivos que alcanzar y se encontrará en el camino obstáculos que dificultan su consecución. El primer paso para resolver problemas y establecer objetivos es identificarlos y representarlos, lo cual casi siempre se hace por medio del lenguaje natural, evidenciando la carencia de métodos formales para el planteamiento de sus enunciados. Por ello, en este artículo se proponen estructuras para expresar objetivos y problemas de manera que se facilite su análisis y se puedan establecer relaciones semánticas y de consistencia entre ellos, empleando lógica de predicados, ya que este mecanismo permite una traducción directa desde lenguaje natural hacia una representación formal de frases para constatar la veracidad o falsedad del enunciado.Organizational world will always have goals to reach and obstacles to fight, in order to reach those goals. Identifying and representing goals and problems are previous stages in solving problems and establishing goals. These tasks are commonly made in natural language, and no formal methods are used on them. For this reason, in this paper we propose first-order-predicate-logic structures for expressing goals and problems, so we can easily analyze them and establish semantic relationships and consistency among them, making a direct translation from natural language to a phrasal formal representation. This representation leads us to assess true-or-false value of statements

Laminin as a Biomarker of Blood–Brain Barrier Disruption under Neuroinflammation: A Systematic Review

Laminin, a non-collagenous glycoprotein present in the brain extracellular matrix, helps to maintain blood–brain barrier (BBB) integrity and regulation. Neuroinflammation can compromise laminin structure and function, increasing BBB permeability. The aim of this paper is to determine if neuroinflammation-induced laminin functional changes may serve as a potential biomarker of alterations in the BBB. The 38 publications included evaluated neuroinflammation, BBB disruption, and laminin, and were assessed for quality and risk of bias (protocol registered in PROSPERO; CRD42020212547). We found that laminin may be a good indicator of BBB overall structural integrity, although changes in expression are dependent on the pathologic or experimental model used. In ischemic stroke, permanent vascular damage correlates with increased laminin expression (β and γ subunits), while transient damage correlates with reduced laminin expression (α subunits). Laminin was reduced in traumatic brain injury and cerebral hemorrhage studies but increased in multiple sclerosis and status epilepticus studies. Despite these observations, there is limited knowledge about the role played by different subunits or isoforms (such as 411 or 511) of laminin in maintaining structural architecture of the BBB under neuroinflammation. Further studies may clarify this aspect and the possibility of using laminin as a biomarker in different pathologies, which have alterations in BBB function in common

Specific nanoprobe design for MRI: Targeting laminin in the blood-brain barrier to follow alteration due to neuroinflammation.

Chronic neuroinflammation is characterized by increased blood-brain barrier (BBB) permeability, leading to molecular changes in the central nervous system that can be explored with biomarkers of active neuroinflammatory processes. Magnetic resonance imaging (MRI) has contributed to detecting lesions and permeability of the BBB. Ultra-small superparamagnetic particles of iron oxide (USPIO) are used as contrast agents to improve MRI observations. Therefore, we validate the interaction of peptide-88 with laminin, vectorized on USPIO, to explore BBB molecular alterations occurring during neuroinflammation as a potential tool for use in MRI. The specific labeling of NPS-P88 was verified in endothelial cells (hCMEC/D3) and astrocytes (T98G) under inflammation induced by interleukin 1β (IL-1β) for 3 and 24 hours. IL-1β for 3 hours in hCMEC/D3 cells increased their co-localization with NPS-P88, compared with controls. At 24 hours, no significant differences were observed between groups. In T98G cells, NPS-P88 showed similar nonspecific labeling among treatments. These results indicate that NPS-P88 has a higher affinity towards brain endothelial cells than astrocytes under inflammation. This affinity decreases over time with reduced laminin expression. In vivo results suggest that following a 30-minute post-injection, there is an increased presence of NPS-P88 in the blood and brain, diminishing over time. Lastly, EAE animals displayed a significant accumulation of NPS-P88 in MRI, primarily in the cortex, attributed to inflammation and disruption of the BBB. Altogether, these results revealed NPS-P88 as a biomarker to evaluate changes in the BBB due to neuroinflammation by MRI in biological models targeting laminin

Estudios de derecho penal. Libro homenaje a Juan Fernández Carrasquilla

El Departamento de Derecho Penal de la Facultad de Derecho de la Universidad de Medellín, con ocasión del septuagésimo aniversario del nacimiento de uno de sus más egregios exponentes -el Profesor Dr. Juan Fernández Carrasquilla, quien impartió las cátedras de Filosofía del Derecho y Derecho penal en esta casa de estudios, la segunda por un lapso superior a 3 lustros- se propuso, en el año 2010, jalonar la elaboración de una obra colectiva destinada a la conmemoración de dicha efemérides y, en consecuencia, rendir tributo y merecido homenaje al autor en cuestión. Habida cuenta las calidades científicas y académicas del profesor Fernández C., de sobra conocidas en el medio, la propuesta rápidamente fue acogida no solo por el grupo de profesores que conforman el Departamento de Derecho Penal de la Universidad de Medellín, sino también por una pléyade de autores colombianos y de otras latitudes que de forma generosa e incondicional quisieron unirse al proyecto original, a quienes, obligado es decirlo, vaya desde ya nuestro sincero y eterno sentimiento de gratitud -de hecho, nos consta que no pocos otros autores nacionales y extranjeros hubieran querido participar; sin embargo, como suele ocurrir en este tipo de obras, ello no fue posible habida cuenta los tiempos establecidos por el editor-o Así las cosas, profesores de Alemania, Argentina, Brasil. Chile, Ecuador, España, Italia, Venezuela y, desde luego, otras universidades colombianas, respondieron a nuestra invitación de manera afirmativa y de forma completamente desinteresada se unieron a la propuesta inicial, colaborando incluso de forma proactiva al buen éxito de la misma