1 research outputs found
Multifunctional Mesoporous Silica-Coated Graphene Nanosheet Used for Chemo-Photothermal Synergistic Targeted Therapy of Glioma
Current
therapy of malignant glioma in clinic is unsatisfactory
with poor patient compliance due to low therapeutic efficiency and
strong systemic side effects. Herein, we combined chemo-photothermal
targeted therapy of glioma within one novel multifunctional drug delivery
system. A targeting peptide (IP)-modified mesoporous silica-coated
graphene nanosheet (GSPI) was successfully synthesized and characterized,
and first introduced to the drug delivery field. A doxorubicin (DOX)-loaded
GSPI-based system (GSPID) showed heat-stimulative, pH-responsive,
and sustained release properties. Cytotoxicity experiments demonstrated
that combined therapy mediated the highest rate of death of glioma
cells compared to that of single chemotherapy or photothermal therapy.
Furthermore, the IP modification could significantly enhance the accumulation
of GSPID within glioma cells. These findings provided an excellent
drug delivery system for combined therapy of glioma due to the advanced
chemo-photothermal synergistic targeted therapy and good drug release
properties of GSPID, which could effectively avoid frequent and invasive
dosing and improve patient compliance