Data_Sheet_1_Fibrosis score predicts mortality in patients with fibrotic hypersensitivity pneumonitis.pdf

BackgroundVariable clinical courses make it challenging to predict mortality resulting from fibrotic hypersensitivity pneumonitis (HP). This study evaluated the usefulness of radiologic parameters for predicting mortality in patients with fibrotic HP.MethodsClinical data and high-resolution computed tomography (HRCT) images, which were scored for reticulation, honeycombing, ground glass opacity (GGO), consolidation, and mosaic attenuation (MA) by visual assessment, were retrospectively analyzed in a total of 101 patients with fibrotic HP (all biopsy-proven cases). Fibrosis score was defined as the sum of reticulation and honeycombing scores.ResultsThe mean age of the 101 patients was 58.9 years, and 60.4% were females. During the follow-up (median: 55.5 months; interquartile range: 37.7–89.0 months), the 1-, 3-and 5-year mortality rates were 3.9, 16.8, and 32.7%, respectively. The non-survivors were older and had significantly lower lung function and minimum oxygen saturation during the 6-min walk test than the survivors. The non-survivors had higher scores of reticulation, honeycombing, GGO, fibrosis, and MA on HRCT than survivors. In the multivariable Cox analysis, reticulation, GGO, and fibrosis scores were independent prognostic factors for mortality in patients with fibrotic HP, as well as age. Fibrosis score showed great performance for predicting the 5-year mortality (AUC = 0.752, p ConclusionOur results suggest that radiologic fibrosis score may be a useful predictor of mortality in patients with fibrotic HP.</p

A fluorogenic calix[4]pyrrole with a small rigid strap showing different fluorescent responses to anions

<p>A strapped calix[4]pyrrole (<b>2</b>) with a fluorogenic pyrene unit linked to the rigid strap via the methylene bridge has been synthesised. It was established by ¹H NMR and fluorescence spectroscopic analyses and isothermal titration calorimetry (ITC) studies that receptor <b>2</b> is capable of binding the F⁻, Cl⁻, (ppi) and anions in organic media, with high selectivity for F⁻ being observed relative to the other anions. Upon exposure to the F⁻ and , the fluorescence of <b>2</b> is quenched, an effect ascribed to facilitated PET (photo-induced electron transfer) from the nitrogen atom to the pyrene moiety, which is induced by anion binding. In contrast, the fluorescence of <b>2</b> was enhanced upon treatment with the HSO₄⁻ anion as the result of the PET inhibition that results from nitrogen atom protonation. A single crystal X-ray structure of the chloride complex of <b>2</b> and the ¹H NMR spectral data revealed that the chloride anion is bound to the receptor via aliphatic C–H•••Cl⁻ hydrogen bonds, as well as N–H•••Cl⁻ interactions.</p

Fabrication of High-Sensitivity Skin-Attachable Temperature Sensors with Bioinspired Microstructured Adhesive

In this study, we demonstrate the fabrication of a highly sensitive flexible temperature sensor with a bioinspired octopus-mimicking adhesive. A resistor-type temperature sensor consisting of a composite of poly­(<i>N</i>-isopropylacrylamide) (pNIPAM)-temperature sensitive hydrogel, poly­(3,4-ethylenedioxythiophene) polystyrene sulfonate, and carbon nanotubes exhibits a very high thermal sensitivity of 2.6%·°C^–1 between 25 and 40 °C so that the change in skin temperature of 0.5 °C can be accurately detected. At the same time, the polydimethylsiloxane adhesive layer of octopus-mimicking rim structure coated with pNIPAM is fabricated through the formation of a single mold by utilizing undercut phenomenon in photolithography. The fabricated sensor shows stable and reproducible detection of skin temperature under repeated attachment/detachment cycles onto skin without any skin irritation for a long time. This work suggests a high potential application of our skin-attachable temperature sensor to wearable devices for medical and health-care monitoring