USCID fourth international conference

Presented at the Role of irrigation and drainage in a sustainable future: USCID fourth international conference on irrigation and drainage on October 3-6, 2007 in Sacramento, California.Includes bibliographical references.Since 3000 BC, rice has been the main crop in the Korean Peninsula, and where currently most of the available irrigation water is used to grow paddy rice. Methods for calculating the quantity of irrigation water required developed in the 1990's were compared to quantities measured in the field. The largest difference between calculated and measured quantities occurred in April and May. Based on field data we obtained in the middle part of the Korean Peninsula, significant changes have occurred in rice management, which has changed the amount of irrigation water required. Rice is now transplanted earlier, and duration of the transplanting phase on the regional scale is shorter through mechanization and consolidation of land holdings. These changes need to be taken into account when calculating the quantity of water needed for irrigation

Deepening regional disparities in primary health care during COVID-19 in South Korea

Introduction: This study investigated the impact of the COVID-19 pandemic on primary healthcare accessibility in South Korea, beyond infectious disease control. The pandemic led to financial challenges for primary healthcare providers, potentially causing clinic closures and exacerbating regional disparities in healthcare resources. The research aimed to analyze changes in private clinic numbers in different regions and assess the resulting shifts in regional disparities in primary healthcare access during the pandemic. Methods: The study classified regions into three categories based on administrative districts: capital area, regional cities, and rural/small cities. Permit data from local governments, publicly disclosed by the national government, were used to analyze changes in private clinic numbers before the COVID-19 pandemic (2017-2019) and after the COVID-19 pandemic onset (2020-2022). Essential medical subjects (internal medicine, general surgery, obstetrics/gynecology, pediatrics (IGOP)) were also analyzed to understand the changes in specific healthcare services. Results: During the onset of the COVID-19 pandemic in 2020, the rate of increase of private clinics decreased across all regions. From 2021, despite ongoing pandemic measures, the capital area and regional cities showed that private clinic increase numbers recovered and exceeded pre-COVID-19 levels in 2022. However, in rural/small cities, private clinic supply per million people in 2022 remained lower than in 2017-2018. Similarly, the supply of IGOP clinics experienced a decrease in 2020 but started to recover in the capital area and regional cities in 2021. In contrast, rural/small cities showed a continuous decrease in IGOP clinic supply during the pandemic period. Disparities between private clinic increases in the capital area/regional cities and rural/small cities intensified in 2021-2022. The overall number of primary healthcare facilities per population continued to increase across regions during the COVID-19 pandemic period. The increase was more pronounced in the capital area and regional cities compared to rural/small cities. Notably, after the onset of the pandemic, there was a reversal in the disparity between regional cities and rural/small cities in terms of primary health care per population. Conclusion: The COVID-19 pandemic has deepened regional disparities in primary healthcare resources in South Korea. In particular, the supply of essential medical services in rural/small cities significantly decreased compared to regional cities during the pandemic. This exacerbates existing health disparities and may hinder equitable healthcare utilization in remote areas. To address this issue, proactive policies are needed, such as expanding public hospitals and increasing the public healthcare workforce in underserved regions. Future research should focus on exploring the underlying causes of healthcare disparities and implementing targeted policy responses to ensure universal and equitable access to healthcare services

Influence of ripening stages on phytochemical composition and bioavailability of ginseng berry (Panax ginseng C.A. Meyer)

The presence of large amounts of bioactive compounds such as saponins and flavonoids in ginseng (Panax ginseng) berry suggests its potential as a functional resource for the food and medical industries, despite the fact that been considered a useless by-products of P. ginseng. In this study, we examined the variations in the antioxidant and anti-melanogenic potential of ginseng berry during the ripening process. We found that fully ripe berry extracts (Go-S3) contained the highest level of antioxidant and anti-melanogenic activities. Phytochemical screening suggested that alterations in polyphenol contents correlated with the variation in bioactive principles of ginseng berry during the ripening process. Furthermore, results obtained by quantitative real-time PCR, western blot, tyrosinase inhibition assay and molecular docking analysis suggested that Go-S3 probably inhibits tyrosinase activity by interacting with copper-coordinating histidines and second shell residues of tyrosinase, resulting in the reduction of melanin production in α-MSH-stimulated B16F10 cells. Taken together, these finding suggest the potential of ginseng berry as a resource for functional applications in the cosmetic industries and demonstrate that fruit ripening stages have profound effects on the pharmaceutical value of ginseng berry

The Rhizome Mixture of Anemarrhena asphodeloides

We investigated the effect of DWac on the gut microbiota composition in mice with 2,3,6-trinitrobenzenesulfonic acid- (TNBS-) induced colitis. Treatment with DWac restored TNBS-disturbed gut microbiota composition and attenuated TNBS-induced colitis. Moreover, we examined the effect of DWac in mice with mesalazine-resistant colitis (MRC). Intrarectal injection of TNBS in MRC mice caused severe colitis, as well as colon shortening, edema, and increased myeloperoxidase activity. Treatment with mesalazine (30 mg/kg) did not attenuate TNBS-induced colitis in MRC mice, whereas treatment with DWac (30 mg/kg) significantly attenuated TNBS-induced colitis. Moreover, treatment with the mixture of mesalazine (15 mg/kg) and DWac (15 mg/kg) additively attenuated colitis in MRC mice. Treatment with DWac and its mixture with mesalazine inhibited TNBS-induced activation of NF-κB and expression of M1 macrophage markers but increased TNBS-suppressed expression of M2 macrophage markers. Furthermore, these inhibited TNBS-induced T-bet, RORγt, TNF-α, and IL-17 expression but increased TNBS-suppressed Foxp3 and IL-10 expression. However, Th2 cell differentiation and GATA3 and IL-5 expression were not affected. These findings suggest that DWac can ameliorate MRC by increasing the polarization of M2 macrophage and correcting the disturbance of gut microbiota and Th1/Th17/Treg, as well as additively attenuating MRC along with mesalazine

The promoter -1031(T/C) polymorphism in tumor necrosis factor-alpha associated with polycystic ovary syndrome

<p>Abstract</p> <p>Background</p> <p>A <it>tumor necrosis factor-alpha </it>is a multifunctional pro-inflammation cytokine, which has been considered as one of pathogenic factors for various diseases. The promoter -1031(T/C) polymorphism in the <it>tumor necrosis factor-alpha </it>gene was reported that it plays a part in reproduction-related diseases. Among these, polycystic ovary syndrome (PCOS) is known to be a common gynecological disease of women in reproductive age women. Here, we performed a comparative study of -1031(T/C) polymorphism of <it>TNF-alpha </it>gene with PCOS in a Korean population.</p> <p>Methods</p> <p>The -1031(T/C) polymorphism of <it>TNF-alpha </it>gene was analyzed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) in a total of 217 PCOS patients and 144 matched female controls of healthy women. And statistical analysis was performed using HapAnalyzer. <it>X</it>²test and logistic regression were utilized analyze the association between two groups. A <it>p</it>-value under 0.05 was considered statistically significant.</p> <p>Results</p> <p>The genotype and allelic frequencies were in Hardy-Weinberg equilibrium (HWE). There was strong association between the -1031(T/C) polymorphism in the promoter region of <it>TNF-alpha </it>gene and PCOS (<it>p</it>-value = 0.0003, odd ratio (OR) = 2.53). In addition, the frequency of C allele was significantly higher in PCOS patients compared with controls. Sequence analyses also showed the -1031(T/C) polymorphism of <it>TNF-alpha </it>gene.</p> <p>Conclusion</p> <p>This is the first study on the -1031(T/C) polymorphism of <it>TNF-alpha </it>gene in PCOS. We concluded that the -1031(T/C) polymorphism of <it>TNF-alpha </it>gene is associated with PCOS in a Korean population. Therefore, it is possible that it may be considered as a clinical biomarker to diagnose for PCOS, and is helpful in understanding the etiology for the pathogenesis of PCOS.</p

The dominant influence of indian ocean dipole-like ocean warming on decreased precipitation over eastern East Antarctica

East Antarctica is undergoing a noticeable decrease in precipitation, significantly impacting ice mass loss. However, there is a lack of research on the underlying factors behind this change. This study highlights that on an interannual timescale, the precipitation variations in Eastern East Antarctica (EEA) are predominantly influenced by the Indian Ocean Dipole mode (IOD) compared to other climate variabilities like the Southern Annular Mode (SAM), El Niño–Southern Oscillation (ENSO), and north Atlantic variability. Through trend analysis of each climate variability, we confirmed that the observed decrease in EEA precipitation can be attributed to positive IOD-like ocean warming. A positive SAM trend also contributed to specific Wilkes Land and Queen Mary Land regions. Despite these influence on long-term trend, the relationship between IOD and EEA precipitation exhibits sporadic changes on interdecadal timescales. Notably, the apparent negative correlation between the two declined to insignificance in the early 2000s, only to re-establish a significant negative correlation by the early 2010s. The primary driver of this change is the inconsistent propagation of waves originating from the Indian Ocean. During periods of high correlation, these waves propagate southeastward, inducing a robust low-pressure anomaly near Victoria Land, ultimately leading to decreased EEA precipitation. However, during periods of low correlation, the waves move eastward and fail to alter the circulation anomalies near East Antarctica

Emotion regulation from a virtue perspective

Background The ability to regulate one’s emotional state is an important predictor of several behaviors such as reframing a challenging situation to reduce anger or anxiety, concealing visible signs of sadness or fear, or focusing on reasons to feel happy or calm. This capacity is referred to as emotion regulation. Deficits in this ability can adversely affect one’s adaptive coping, thus are associated with a variety of other psychopathological symptoms, including but not limited to depression, borderline personality disorder, substance use disorders, eating disorders, and somatoform disorders. Methods The present study examined emotion regulation in relation to the virtue-based psychosocial adaptation model (V-PAM). 595 participants were clustered based on their Difficulties in Emotion Regulation Scale (DERS) score, producing two clusters (i.e., high functioning vs. low functioning). Then, emotion regulation group membership was discriminated by using five V-PAM virtue constructs, including courage, integrity, practical wisdom, committed action, and emotional transcendence. Results Results show that five virtues contribute to differentiating group membership. Practical wisdom was the strongest contributor, followed by integrity, emotional transcendence, committed action, and courage. Predictive discriminant analysis was conducted and 71% of cases were correctly classified. A discussion of the relationship between emotion regulation and virtues was elaborated. Conclusion The concept of virtue holds significant importance in the comprehension of an individual’s capacity to regulate their emotions, meriting future study. Methods: The present study examined emotion regulation in relation to the virtue-based psychosocial adaptation model (V-PAM). 595 participants were clustered based on their Difficulties in Emotion Regulation Scale (DERS) score, producing two clusters (i.e., high functioning vs. low functioning). Then, emotion regulation group membership was discriminated by using five V-PAM virtue constructs, including courage, integrity, practical wisdom, committed action, and emotional transcendence. Results: Results show that five virtues contribute to differentiating group membership. Practical wisdom was the strongest contributor, followed by integrity, emotional transcendence, committed action, and courage. Predictive discriminant analysis was conducted and 71% of cases were correctly classified. A discussion of the relationship between emotion regulation and virtues was elaborated. Conclusion: The concept of virtue holds significant importance in the comprehension of an individual\u27s capacity to regulate their emotions, meriting future study