Cortical regions displaying thinning of the cortex and increased surface area in PSP.

<p>X;Y;Z in Talairach coordinates. All results presented at the corrected threshold (p <0.05).</p><p>MSA  =  Multiple Systems Atrophy; PSP  =  Progressive Supranuclear Palsy; PD  =  Parkinson's Disease.</p><p>Cortical regions displaying thinning of the cortex and increased surface area in PSP.</p

Cortical areas showing significant thinning in PSP patients compared to a) healthy controls, b) Parkinson's disease and c) Multiple System Atrophy; displayed on QDEC's semi-inflated cortical surfaces.

<p>Top row: L lateral and L medial, Second row: R lateral and R medial, Third row: anterior and posterior, Bottom row: superior and inferior views. The colour bar indicates the significance levels of the clusters. Results were obtained using Monte Carlo simulation, with a threshold of p <0.05, to provide cluster-wise correction for multiple comparisons.</p

Cortical areas showing significantly increased surface area in PSP patients compared to Multiple System Atrophy; displayed on QDEC's semi-inflated cortical surfaces.

<p>Top row: L lateral and L medial, Second row: R lateral and R medial, Third row: anterior and posterior, Bottom row: superior and inferior views. The colour bar indicates the significance levels of the clusters. Results were obtained using Monte Carlo simulation, with a threshold of p <0.05, to provide cluster-wise correction for multiple comparisons.</p

White matter maps showing regions of significant decreased fractional anisotropy and increased mean diffusivity in MSA patients when compared to healthy controls and PD (Bonferroni corrected alpha = 0.0167).

<p>Background image corresponds to the mean fractional anisotropy image of all subjects in standard MNI152 space (radiological view). Fractional anisotropy white matter skeleton is represented by green voxels. Blue voxels represent regions of decreased FA and yellow voxels represent regions of increased MD in the PSP group.</p

White matter regions of fractional anisotropy changes between PSP, MSA, PD and HC.

<p>All results reported at p<0.05, TFCE and Bonferroni corrected (corrected alpha = 0.0167).</p><p>White matter regions of fractional anisotropy changes between PSP, MSA, PD and HC.</p

Demographic and clinical data of control subjects and patients with PD, MSA and PSP.

<p>* For patients taking levodopa drug treatment, scores given in the ‘on’ state.</p>†<p>From Parkinson's Plus Scale (Cerebellar Score, maximum 24; Occulomotor Score, maximum 21).</p><p>MSA  =  multiple systems atrophy; PSP  =  progressive supranuclear palsy; PD  =  Parkinson's disease; MSA-P  =  multiple system atrophy parkinsonian variant; MSA-C  =  multiple system atrophy cerebellar variant; H&Y  =  Hoehn and Yahr; ADL  =  activities of daily living; UPDRS III  =  Unified Parkinson Disease Rating Scale-part III.</p><p>Demographic and clinical data of control subjects and patients with PD, MSA and PSP.</p

White matter maps showing regions of significant correlation between mean diffusivity and measures of disease severity (Bonferroni corrected alpha = 0.0167).

<p>Top row coronal view, bottom row axial view. Background image corresponds to the mean fractional anisotropy image of all subjects in standard MNI152 space (radiological view). Fractional anisotropy white matter skeleton is represented by green voxels. Blue voxels represent regions of decreased FA and yellow voxels represent regions of increased MD in the PSP group.</p

White matter regions of mean diffusivity changes between PSP, MSA, PD and HC.

<p>All results reported at p<0.05, TFCE and Bonferroni corrected (corrected alpha 0.0167).</p><p>White matter regions of mean diffusivity changes between PSP, MSA, PD and HC.</p

White matter maps showing regions of significant decreased fractional anisotropy and increased mean diffusivity in PSP patients when compared to healthy controls, PD and MSA (Bonferroni corrected alpha = 0.0167).

<p>Background image corresponds to the mean fractional anisotropy image of all subjects in standard MNI152 space (radiological view). Fractional anisotropy white matter skeleton is represented by green voxels. Blue voxels represent regions of decreased FA and yellow voxels represent regions of increased MD in the PSP group.</p