8 research outputs found
Mean brain edge movement (reduction) by brain region in schizophrenia and during the 9-year follow-up time.
<p>Note: *p-values from group comparison adjusted for sex.</p
Clinical characteristics of participants with schizophrenia.
a<p>PANSS, Positive and Negative Syndrome Scale, assessment of the PANSS in the baseline and 9 year follow-up are not completely comparable (please see text in methods).</p>b<p>Social and Occupational Functioning Assessment Scale.</p>c<p>Equivalent to 100 mg daily chlorpromazine during the 9-year follow-up.</p
Linear regression analysis of the association between annual brain volume reduction and amount of antipsychotic medication (log dose years of daily equivalent of 100 mg chlorpromazine separately in typical, atypical and any antipsychotics) during the 9-year follow-up time.
a<p>unadjusted model. All betas are standardised.</p>b<p>adjusted for mean total PANSS, logarithm of alcohol use and weight change.</p>c<p>adjusted for change in total PANSS, logarithm of alcohol use and weight change.</p>d<p>adjusted for mean SOFAS, logarithm of alcohol use and weight change.</p>e<p>adjusted for change in SOFAS, logarithm of alcohol use and weight change.</p
Mean of the annual change of total brain volume (%) during the 9-year follow-up period in participants with schizophrenia and control participants.
<p>SD â=â Standard Deviation.</p><p>Q<sub>1</sub> â=â first quartile, Q<sub>3</sub> â=â third quartile.</p>a<p>Independent samples t-test.</p>b<p>Adjusted for sex.</p>c<p>Adjusted for sex, educational level, logarithm of the alcohol use (g/day) and weight change (kg).</p
Linear regression between annual brain change and mean PANSS scores, change in PANSS scores, mean SOFAS and change in SOFAS score.
a<p>Standardized betas.</p
Sociodemographic background and handedness in the schizophrenia and control groups.
<p>Sociodemographic background and handedness in the schizophrenia and control groups.</p
Scatter blot of annual brain volume change in schizophrenia and control groups.
<p>Scatter blot of annual brain volume change in schizophrenia and control groups.</p
Linear regression between dose years (equivalent to daily 100 mg chlorpromazine) of antipsychotic medication and annual change in brain volume (%) in participants with schizophrenia (betaâ=ââ0.50, tâ=ââ3.23, pâ=â0.003).
<p>1000 mg chlorpromazine daily for a duration of 9 years equals 90 dose years.</p