128 research outputs found
String and M-theory Deformations of Manifolds with Special Holonomy
The R^4-type corrections to ten and eleven dimensional supergravity required
by string and M-theory imply corrections to supersymmetric supergravity
compactifications on manifolds of special holonomy, which deform the metric
away from the original holonomy. Nevertheless, in many such cases, including
Calabi-Yau compactifications of string theory and G_2-compactifications of
M-theory, it has been shown that the deformation preserves supersymmetry
because of associated corrections to the supersymmetry transformation rules,
Here, we consider Spin(7) compactifications in string theory and M-theory, and
a class of non-compact SU(5) backgrounds in M-theory. Supersymmetry survives in
all these cases too, despite the fact that the original special holonomy is
perturbed into general holonomy in each case.Comment: Improved discussion of SU(5) holonomy backgrounds. Other minor typos
corrected. Latex with JHEP3.cls, 42 page
Structure determination of PF3 adsorption on Cu(100) using X-ray standing waves
The local structure of the Cu(100)c(4x2)-PF3 adsorption phase has been investigated through the use of normal-incidence X-ray standing waves (NIXSW), monitored by P 1s and F 1s photoemission, together with P K-edge near-edge X-ray absorption fine structure (NEXAFS). NEXAFS shows the molecule to be oriented with its C3v symmetry axis essentially perpendicular to the surface, while the P NIXSW data show the molecule to be adsorbed in atop sites 2.37±0.04 Ă
above the surface, this distance corresponding to the Cu-P nearest-neighbour distance in the absence of any surface relaxation. F NIXSW indicates a surprisingly small height difference of the P and F atoms above the surface 0.44±0.06 Ă
, compared with the value expected for an undistorted gas-phase geometry of 0.77 Ă
, implying significant increases in the F-P-F bond angles. In addition, however, the F NIXSW data indicate that the molecules have a well-defined azimuthal orientation with a molecular mirror plane aligned in a substrate mirror plane, and with a small (5-10°) tilt of the molecule in this plane such that the two symmetrically-equivalent F atoms in each molecule are tilted down towards the surface
Timing of restoration of bowel continuity after decompressing stoma, in left-sided obstructive colon cancer:a nationwide retrospective cohort
BACKGROUND: With the increasing use of decompressing stoma as a bridge to surgery for left-sided obstructive colon cancer (LSOCC), the timing of restoration of bowel continuity (ROBC) is a subject of debate. There is a lack of data on immediate ROBC during elective resection as an alternative for a 3-stage procedure. This study analysed if immediate ROBC during tumour resection is safe and of any benefit for patients who underwent decompressing stoma for LSOCC. METHODS: In a Dutch nationwide collaborative research project, 3153 patients who underwent resection for LSOCC in 75 hospitals (2009-2016) were identified. Extensive data on disease and procedural characteristics, and outcomes was collected by local collaborators. For this analysis, 332 patients who underwent decompressing stoma followed by curative resection were selected. Immediate ROBC during tumour resection was compared to two no immediate ROBC groups, (1) tumour resection with primary anastomosis (PA) with leaving the decompressing stoma in situ, and (2) tumour resection without PA. RESULTS: Immediate ROBC was performed in 113 patients (34.0%) and no immediate ROBC in 219 patients [168 with PA (50.6%) and 51 patients without PA (15.4%)]. No differences at baseline between the groups were found for age, ASA score, cT, and cM. Major surgical complications (8.8% immediate ROBC vs. 4.8% PA with decompressing stoma and 7.8% no PA; P =0.37) and mortality (2.7% vs. 2.4% and 0%, respectively; P =0.52) were similar. Immediate ROBC resulted in a shorter time with a stoma (mean 41 vs. 240 and 314 days, respectively; P <0.001), and fewer permanent stomas (7% vs. 21% and 80%, respectively; P <0.001) as compared to PA with a decompressing stoma or no PA. CONCLUSION: After a decompressing stoma for LSOCC, immediate ROBC during elective resection appears safe, reduces the total time with a stoma and the risk of a permanent stoma.</p
M-theory on eight-manifolds revisited: N=1 supersymmetry and generalized Spin(7) structures
The requirement of supersymmetry for M-theory backgrounds of the
form of a warped product , where is an eight-manifold
and is three-dimensional Minkowski or AdS space, implies the
existence of a nowhere-vanishing Majorana spinor on . lifts to a
nowhere-vanishing spinor on the auxiliary nine-manifold , where
is a circle of constant radius, implying the reduction of the structure
group of to . In general, however, there is no reduction of the
structure group of itself. This situation can be described in the language
of generalized structures, defined in terms of certain spinors of
. We express the condition for supersymmetry
in terms of differential equations for these spinors. In an equivalent
formulation, working locally in the vicinity of any point in in terms of a
`preferred' structure, we show that the requirement of
supersymmetry amounts to solving for the intrinsic torsion and all irreducible
flux components, except for the one lying in the of , in
terms of the warp factor and a one-form on (not necessarily
nowhere-vanishing) constructed as a bilinear; in addition, is
constrained to satisfy a pair of differential equations. The formalism based on
the group is the most suitable language in which to describe
supersymmetric compactifications on eight-manifolds of structure,
and/or small-flux perturbations around supersymmetric compactifications on
manifolds of holonomy.Comment: 24 pages. V2: introduction slightly extended, typos corrected in the
text, references added. V3: the role of Spin(7) clarified, erroneous
statements thereof corrected. New material on generalized Spin(7) structures
in nine dimensions. To appear in JHE
A Note on Flux Induced Superpotentials in String Theory
Non-vanishing fluxes in M-theory and string theory compactifications induce a
superpotential in the lower dimensional theory. Gukov has conjectured the
explicit form of this superpotential. We check this conjecture for the
heterotic string compactified on a Calabi-Yau three-fold as well as for warped
M-theory compactifications on Spin(7) holonomy manifolds, by performing a
Kaluza-Klein reduction.Comment: 19 pages, no figure
Origin of Life
The evolution of life has been a big enigma despite rapid advancements in the
fields of biochemistry, astrobiology, and astrophysics in recent years. The
answer to this puzzle has been as mind-boggling as the riddle relating to
evolution of Universe itself. Despite the fact that panspermia has gained
considerable support as a viable explanation for origin of life on the Earth
and elsewhere in the Universe, the issue remains far from a tangible solution.
This paper examines the various prevailing hypotheses regarding origin of life
like abiogenesis, RNA World, Iron-sulphur World, and panspermia; and concludes
that delivery of life-bearing organic molecules by the comets in the early
epoch of the Earth alone possibly was not responsible for kick-starting the
process of evolution of life on our planet.Comment: 32 pages, 8 figures,invited review article, minor additio
The development of an online decision aid to support persons having a genetic predisposition to cancer and their partners during reproductive decision-making: a usability and pilot study
An online decision aid to support persons having a genetic predisposition to cancer and their partners during reproductive decision-making was developed. A two-phase usability test was conducted among 12 couples (N = 22; 2 persons participated without their partner) at risk for hereditary cancer and 15 health care providers. Couples and health care providers expressed similar suggestions for improvements, and evaluated the modified decision aid as acceptable, easy to use, and comprehensible. The final decision aid was pilot tested (N = 16) with paired sample t tests comparing main outcomes (decisional conflict, knowledge, realistic expectations regarding the reproductive options and decision self-efficacy) before (T0), immediately (T1) and 2 weeks after (T2) use of the decision aid. Pilot testing indicated decreased decisional conflict scores, increased knowledge, and improved realistic expectations regarding the reproductive options, at T1 and T2. No effect was found for couplesâ decision self-efficacy. The positive findings during usability testing were thus reflected in the pilot study. The decision aid will be further evaluated in a nationwide pretestâposttest study to facilitate implementation in the onco-genetic counselling setting. Ultimately, it is expected that the decision aid will enable end-users to make an informed decision
Magnetic field generation from non-equilibrium phase transitions
We study the generation of magnetic fields during the stage of particle
production resulting from spinodal instabilities during phase transitions out
of equilibrium. The main premise is that long-wavelength instabilities that
drive the phase transition lead to strong non-equilibrium charge and current
fluctuations which generate electromagnetic fields. We present a formulation
based on the non-equilibrium Schwinger-Dyson equations that leads to an exact
expression for the spectrum of electromagnetic fields valid for general
theories and cosmological backgrounds and whose main ingredient is the
transverse photon polarization out of equilibrium. This formulation includes
the dissipative effects of the conductivity in the medium. As a prelude to
cosmology we study magnetogenesis in Minkowski space-time in a theory of N
charged scalar fields to lowest order in the gauge coupling and to leading
order in the large N within two scenarios of cosmological relevance. The
long-wavelength power spectrum for electric and magnetic fields at the end of
the phase transition is obtained explicitly.
It follows that equipartition between electric and magnetic fields does not
hold out of equilibrium. In the case of a transition from a high temperature
phase, the conductivity of the medium severely hinders the generation of
magnetic fields, however the magnetic fields generated are correlated on scales
of the order of the domain size, which is much larger than the magnetic
diffusion length. Implications of the results to cosmological phase transitions
driven by spinodal unstabilities are discussed.Comment: Preprint no. LPTHE 02-55, 30 pages, latex, 2 eps figures. Added one
reference. To appear in Phys. Rev.
Mesoscopic models for DNA stretching under force: new results and comparison to experiments
Single molecule experiments on B-DNA stretching have revealed one or two
structural transitions, when increasing the external force. They are
characterized by a sudden increase of DNA contour length and a decrease of the
bending rigidity. It has been proposed that the first transition, at forces of
60--80 pN, is a transition from B to S-DNA, viewed as a stretched duplex DNA,
while the second one, at stronger forces, is a strand peeling resulting in
single stranded DNAs (ssDNA), similar to thermal denaturation. But due to
experimental conditions these two transitions can overlap, for instance for
poly(dA-dT). We derive analytical formula using a coupled discrete worm like
chain-Ising model. Our model takes into account bending rigidity, discreteness
of the chain, linear and non-linear (for ssDNA) bond stretching. In the limit
of zero force, this model simplifies into a coupled model already developed by
us for studying thermal DNA melting, establishing a connexion with previous
fitting parameter values for denaturation profiles. We find that: (i) ssDNA is
fitted, using an analytical formula, over a nanoNewton range with only three
free parameters, the contour length, the bending modulus and the monomer size;
(ii) a surprisingly good fit on this force range is possible only by choosing a
monomer size of 0.2 nm, almost 4 times smaller than the ssDNA nucleobase
length; (iii) mesoscopic models are not able to fit B to ssDNA (or S to ss)
transitions; (iv) an analytical formula for fitting B to S transitions is
derived in the strong force approximation and for long DNAs, which is in
excellent agreement with exact transfer matrix calculations; (v) this formula
fits perfectly well poly(dG-dC) and -DNA force-extension curves with
consistent parameter values; (vi) a coherent picture, where S to ssDNA
transitions are much more sensitive to base-pair sequence than the B to S one,
emerges.Comment: 14 pages, 9 figure
Reproductive decision-making in the context of hereditary cancer: the effects of an online decision aid on informed decision-making
Individuals having a genetic predisposition to cancer and their partners face challenging decisions regarding their wish to have children. This study aimed to determine the effects of an online decision aid to support couples in making an informed decision regarding their reproductive options. A nationwide pretest-posttest study was conducted in the Netherlands among 131 participants between November 2016 and May 2018. Couples were eligible for participation if one partner had a pathogenic variant predisposing for an autosomal dominant hereditary cancer syndrome. Participants completed a questionnaire before use (T0), and at 3 months (T3) after use of the decision aid to assess the primary outcome measure informed decision-making, and the secondary outcome measures decisional conflict, knowledge, realistic expectations, level of deliberation, and decision self-efficacy. T0âT3 comparisons show an overall positive effect for all outcome measures (all ps < 0.05; knowledge (ES = â 1.05), decisional conflict (ES = 0.99), participantsâ decision self-efficacy (ES = â0.55), level of deliberation (ES = â 0.50), and realistic expectations (ES = â 0.44). Informed decision-making increased over time and 58.0% of the participants made an informed reproductive decision at T3. The online decision aid seems to be an appropriate tool to complement standard reproductive counseling to support our target group in making an informed reproductive decision. Use of the decision aid may lessen the negative psychological impact of decision-making on couplesâ daily life and wellbeing
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