Clinical-pathological characteristics of the prostate cancer patients.

<p>Clinical-pathological characteristics of the prostate cancer patients.</p

Demographic and clinico-pathological characteristics of the participants for urine samples.

<p>Demographic and clinico-pathological characteristics of the participants for urine samples.</p

Comparison of miRNA expression on the basis of ethnicity.

<p>Box plots represent the fold difference in expression levels of four miRNAs in PCa tissues as compared to their normal adjacent counterpart. Data for 15 Caucasian American (CA) and 25 African American (AA) patients as assessed by qRT-PCR is shown. Expression levels of the miRNAs were normalized to U6 snRNA as endogenous control. Statistically significant differences were determined using unpaired Student’s T-test.</p

Pathway network of the genes targeted by differentially modulated miRNAs.

<p>Pathway network was constructed for commonly predicted target mRNAs of differentially modulated miRNAs (miR-205, miR-214, miR-221 and miR99b), by using Pathway Studio 9.0 (A) Commonly predicted miRNA targets with common regulators. (B) Directly interacting targets.</p

Differentially expressed miRNAs in Prostate Cancer Tissues.

*<p>miRNAs selected for tissue validation.</p

Prognostic accuracy of miR-205 and miR-214 in urine samples.

<p>The quantification of miR-205 and miR-214 together can enhance the diagnostic value and can be used to discriminate PCa patients from healthy individuals with 89% sensitivity and 80% specificity.</p