A randomized trial comparing perinatal outcomes using insulin detemir or neutral protamine Hagedorn in type 1 diabetes

OBJECTIVE: This randomized controlled trial aimed to compare the efficacy and safety of insulin detemir (IDet) with neutral protamine Hagedorn (NPH), both with insulin aspart, in pregnant women with type 1 diabetes. The perinatal and obstetric pregnancy outcomes are presented. METHODS: Subjects were randomized to IDet (n = 152) or NPH (n = 158) ≤12 months before pregnancy or at 8–12 gestational weeks. RESULTS: For IDet and NPH, there were 128 and 136 live births, 11 and 9 early fetal losses, and two and one perinatal deaths, respectively. Gestational age at delivery was greater for children from the IDet arm than the NPH arm (treatment difference: 0.49 weeks [95% CI 0.11;0.88], p = 0.012, linear regression). Sixteen children had a malformation (IDet: n = 8/142, 5.6%; NPH: n = 8/145, 5.5%). The incidence of adverse events was similar between treatments. CONCLUSION: IDet is as well tolerated as NPH as regards perinatal outcomes in pregnant women with type 1 diabetes and no safety issues were identified

Field Experience with Soil Gas Mapping Using Japanese Passive Radon/Thoron Discriminative Detectors for Comparing High and Low Radiation Areas in Serbia (Balkan Region)

Radon/Thoron/Natural radioactivity/Niska Banja/Obrenovac. Based oil results of fieldwork in the Balkan Region of Serbia from 2005 to 2007, soil gas radon and thoron concentrations as well as gamma dose rates were measured. Campaigns were conducted in two different geological regions: Niska Banja, considered a high natural radiation area, and Obrenovac around the TentB Thermal Power Plant (TPP), a low natural radiation area. Radon and thoron gas measurements were made by using two types of Japanese passive radon/thoron detectors, Which included GPS data and gamma dose rates. The concentrations of soil radon gas in Niska Banja ranged from 1.8 to 161.1 kBq m(-3) the concentrations for soil thoron gas ranged from 0.9 to 23.5 kBq m(-3). The gamma close rates varied from 70 to 320 nGy h(-1). In the TentB area, radon concentration was found to range from 0.8 to 24.9 kBq m(-3) and thoron from 0.6 to 1.9 kBq m(-3). The gamma dose rate ranged from 90 to 130 nGy h(-1). In addition, the natural radioactivity of the soil was investigated at the low background area. The radium and thorium contents in collected soil samples ranged from 23 to 58 and 33 to 67 Bq kg(-1), respectively. As a result of correlation analyses between the measured values, the highest correlation coefficient (R GT 0.95) was found for thorium ill the soil and the thoron gas concentration