3 research outputs found
Solubility Prediction of Paracetamol in WaterâEthanolâPropylene Glycol Mixtures at 25 and 30 °C Using Practical Approaches
The solubility of paracetamol in waterâethanolâpropylene glycol binary and ternary mixtures at 25 and
30 °C was determined using flask shake method. The generated data extended the solubility database for further
computational investigations and also was used to assess the prediction capability of the JouybanâAcree model.
A new version of the model was proposed for modeling the solubility data in waterâcosolvent mixtures with the
cosolvent concentration of 50% which is required in pharmaceutical formulations. The accuracy of the predicted
solubilities was evaluated by the mean percentage deviation (MPD) between the predicted and experimental
solubilities. The overall MPD of the JouybanâAcree model and the log-linear model of Yalkowsky for the entire
composition range of the cosolvents were 11.08.7 and 55.417.8%, respectively; the corresponding values
for the predicted solubilities in mixtures having a cosolvent concentration of 50% were 12.09.1 and
22.011.0%