272 research outputs found

    Comment on “Measurement and Correlation of Solubilities of ( Z

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    Article commenting on an article titled, "Measurement and correlation of solubilities of (Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetic acid in different pure solvents and binary mixtures of water + (ethanol, methanol, or glycol)," published in March 2011

    Review of Pharmaceutical Applications of N-Methyl-2-Pyrrolidone

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    ABSTRACT -N-Methyl-2-pyrrolidone (NMP) is a very strong solubilizing agent that has important applications in different fields of industry. This review presents NMP's physicochemical characteristics, its applications -especially in the pharmaceutical sciences, pharmacokinetics and toxicity. The characteristics of NMP, such as physicochemical properties, solubilization efficacy, toxicity, and adverse effects, are compared with those of other common solvents used in pharmaceutical industries. This review shows that NMP is an acceptable pharmaceutical solvent and that its efficacy, toxicity, and side effects are comparable with those of other common solvents. ______________________________________________________________________________________
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