Marginal effects of FINDRISC items and other covariates on the 15D HRQoL index.

<p>Marginal effects of FINDRISC items and other covariates on the 15D HRQoL index.</p

Mean observed HRQoL (15D) dimension values in relation to the FINDRISC score.

<p>Linear trends were fitted to data using ordinary least squares regression. The corresponding variance was estimated using a bootstrap procedure with 1,000 replications. HRQoL: Health-related quality of life. FINDRISC: Finnish Diabetes Risk Score.</p

Observed mean HRQoL index values and fitted linear trends (95% CI) in relation to the FINDRISC scores.

<p>Linear trends were fitted to data using Tobit regression. The corresponding variance was estimated using a bootstrap procedure with 1,000 replications.*Adjusted for sex, employment and cohabiting. HRQoL: Health-related quality of life. FINDRISC: Finnish Diabetes Risk Score.</p

The characteristics of the participants across the diabetes risk (FINDRISC) categories.

<p>The characteristics of the participants across the diabetes risk (FINDRISC) categories.</p

Marginal effects of FINDRISC items and other covariates on the SF-6D HRQoL index.

<p>Marginal effects of FINDRISC items and other covariates on the SF-6D HRQoL index.</p

GxE signals.

<p>(A) Number of reQTLs per clinical variable (10% FDR). (B) Number of tSNP-environment associations per clinical variable (10% FDR).</p

GTEx replication.

<p>Replication rate (y axis) as a function of FUSION reQTL p-value cutoff (x axis). Dashed line represents two standard deviations from the null distribution, calculated using the hypergeometric distribution.</p

reQTL results FDR 10%.

<p>reQTL results FDR 10%.</p

<i>FHOD3</i> locus.

<p>(A) Top wiggle tracks show ATAC-seq signal in multiple cell types, followed by ChromHMM chromatin state tracks. Beneath are <i>FHOD3</i> GWAS loci and the SNPs from this study (reQTL and tSNP). The bottom track shows the FUSION <i>FHOD3</i> RNA-seq signal. (B) ATAC-seq signal highlights potential regulatory regions with the skeletal muscle stretch enhancer. (C) Effects of SNPs overlapping ATAC-seq peaks in the reQTL haplotype on in silico predicted TF binding.</p

<i>FHOD3</i> reQTL, rs17746240 (18:33970347).

<p>The data for each of the three possible reQTL genotypes are presented in separate plots (columns). The top row plots show the relationship between gene expression (y axis) and the clinical variable (x axis). The bottom row plots show the relationship between the allelic imbalance of the tSNP and the clinical variable (x axis). Note the bottom row has fewer samples because it is limited to samples heterozygous for the tSNP. (A) LDLc GxE effect with rs72895597 (18:34232657) as the tSNP. (B) SBP GxE effect with rs2303510 (18:34324091) as the tSNP.</p