15 research outputs found
Pre-treatment anemia evaluation in cancer patients attending radiotherapy clinic: Results from a single Indian center
Pre-treatment anemia evaluation in cancer patients attending radiotherapy clinic: Results from a single Indian center
Normal tissue complication probability: Does simultaneous integrated boost intensity-modulated radiotherapy score over other techniques in treatment of prostate adenocarcinoma
Aim: The main objective of this study was to analyze the
radiobiological effect of different treatment strategies on high-risk
prostate adenocarcinoma. Materials and Methods: Ten cases of high-risk
prostate adenocarcinoma were selected for this dosimetric study. Four
different treatment strategies used for treating prostate cancer were
compared. Conventional four-field box technique covering prostate and
nodal volumes followed by three-field conformal boost (3D + 3DCRT),
four-field box technique followed by intensity-modulated radiotherapy
(IMRT) boost (3D + IMRT), IMRT followed by IMRT boost (IMRT + IMRT),
and simultaneous integrated boost IMRT (SIBIMRT) were compared in terms
of tumor control probability (TCP) and normal tissue complication
probability (NTCP). The dose prescription except for SIBIMRT was 45 Gy
in 25 fractions for the prostate and nodal volumes in the initial phase
and 27 Gy in 15 fractions for the prostate in the boost phase. For
SIBIMRT, equivalent doses were calculated using biologically equivalent
dose assuming the \u3b1/\u3b2 ratio of 1.5 Gy with a dose
prescription of 60.75 Gy for the gross tumor volume (GTV) and 45 Gy for
the clinical target volume in 25 fractions. IMRT plans were made with
15-MV equispaced seven coplanar fields. NTCP was calculated using the
Lyman-Kutcher-Burman (LKB) model. Results: An NTCP of 10.7 \ub1
0.99%, 8.36 \ub1 0.66%, 6.72 \ub1 0.85%, and 1.45 \ub1 0.11% for
the bladder and 14.9 \ub1 0.99%, 14.04 \ub1 0.66%, 11.38 \ub1
0.85%, 5.12 \ub1 0.11% for the rectum was seen with 3D + 3DCRT, 3D +
IMRT, IMRT + IMRT, and SIBIMRT respectively. Conclusions: SIBIMRT had
the least NTCP over all other strategies with a reduced treatment time
(3 weeks less). It should be the technique of choice for dose
escalation in prostate carcinoma
Normal tissue complication probability of fibrosis in radiotherapy of breast cancer: Accelerated partial breast irradiation vs conventional external-beam radiotherapy
Normal tissue complication probability: Does simultaneous integrated boost intensity-modulated radiotherapy score over other techniques in treatment of prostate adenocarcinoma
Aim: The main objective of this study was to analyze the
radiobiological effect of different treatment strategies on high-risk
prostate adenocarcinoma. Materials and Methods: Ten cases of high-risk
prostate adenocarcinoma were selected for this dosimetric study. Four
different treatment strategies used for treating prostate cancer were
compared. Conventional four-field box technique covering prostate and
nodal volumes followed by three-field conformal boost (3D + 3DCRT),
four-field box technique followed by intensity-modulated radiotherapy
(IMRT) boost (3D + IMRT), IMRT followed by IMRT boost (IMRT + IMRT),
and simultaneous integrated boost IMRT (SIBIMRT) were compared in terms
of tumor control probability (TCP) and normal tissue complication
probability (NTCP). The dose prescription except for SIBIMRT was 45 Gy
in 25 fractions for the prostate and nodal volumes in the initial phase
and 27 Gy in 15 fractions for the prostate in the boost phase. For
SIBIMRT, equivalent doses were calculated using biologically equivalent
dose assuming the α/β ratio of 1.5 Gy with a dose
prescription of 60.75 Gy for the gross tumor volume (GTV) and 45 Gy for
the clinical target volume in 25 fractions. IMRT plans were made with
15-MV equispaced seven coplanar fields. NTCP was calculated using the
Lyman-Kutcher-Burman (LKB) model. Results: An NTCP of 10.7 ±
0.99%, 8.36 ± 0.66%, 6.72 ± 0.85%, and 1.45 ± 0.11% for
the bladder and 14.9 ± 0.99%, 14.04 ± 0.66%, 11.38 ±
0.85%, 5.12 ± 0.11% for the rectum was seen with 3D + 3DCRT, 3D +
IMRT, IMRT + IMRT, and SIBIMRT respectively. Conclusions: SIBIMRT had
the least NTCP over all other strategies with a reduced treatment time
(3 weeks less). It should be the technique of choice for dose
escalation in prostate carcinoma
Normal tissue complication probability of fibrosis in radiotherapy of breast cancer: Accelerated partial breast irradiation vs conventional external-beam radiotherapy
Aims: Radiotherapy forms an integral part of breast-conserving
treatment in early-stage breast cancer. Subcutaneous fibrosis of the
treated breast is an important late effect in whole-breast irradiation.
The aim of this study was to compare the normal tissue complication
probability (NTCP) for radiation-induced fibrosis in treated breast
using accelerated partial-breast irradiation (APBI) vs conventional
treatment. Materials and Methods: Ten postoperative early-stage breast
cancer patients (T1N0M0) were included in this dosimetric analysis.
APBI treatment was planned using conformal radiotherapy technique and
conventional treatment plans included two tangential portals. All the
APBI treatment plans were made with five non-coplanar beams with 6 MV
photons. The prescription dose was 38 Gy in 10 fractions for the APBI
treatments and 50 Gy in 25 fractions, followed by a boost dose of 16 Gy
in 8 fractions, for the conventional treatments. We used Lyman′s
relative-seriality model and the breast fibrosis NTCP model fitting
parameters for the study. Results: The equivalent uniform dose (EUD)
was 30.09 Gy and 50.79 Gy in APBI and conventional treatment,
respectively. The mean NTCP values for ipsilateral breast fibrosis in
APBI and conventional treatment were 0.51 and 25.66%, respectively.
Using the paired t-test, a statistically significant difference was
seen in the breast fibrosis NTCP values for APBI vs conventional
treatment (P < 0.001). Conclusions: APBI reduces the ipsilateral
breast fibrosis compared to conventional whole-breast treatment in
early-stage breast cancer
Reirradiation for progressive brain metastases
Brain metastases constitute one of the most common distant metastases
of cancer and are increasingly being detected with better diagnostic
tools. The standard of care for solitary brain metastases with the
primary disease under control is surgery followed by radiotherapy.
Radiotherapy is also the primary modality for the treatment of multiple
brain metastases, and improves both the quality of life and survival of
patient. Unfortunately, more than half of these treated patients
eventually progress leading to a therapeutic dilemma. Another course of
radiotherapy is a viable but underutilized option. Reirradiation
resolves distressing symptoms and has shown to improve survival with
minimal late neurotoxicity. Reirradiation has conventionally been done
with whole brain radiotherapy, but now studies with stereotactic
radiosurgery have also shown promising results. In this review, we
focus on reirradiation as a treatment modality in such patients. We
performed a literature search in MEDLINE (www.pubmed.org) with key
words brain metastases, reirradiation, whole brain radiotherapy,
stereotactic radiosurgery, interstial brachytherapy, and brain. The
search was limited to the English literature and human subjects
Reirradiation for progressive brain metastases
Brain metastases constitute one of the most common distant metastases
of cancer and are increasingly being detected with better diagnostic
tools. The standard of care for solitary brain metastases with the
primary disease under control is surgery followed by radiotherapy.
Radiotherapy is also the primary modality for the treatment of multiple
brain metastases, and improves both the quality of life and survival of
patient. Unfortunately, more than half of these treated patients
eventually progress leading to a therapeutic dilemma. Another course of
radiotherapy is a viable but underutilized option. Reirradiation
resolves distressing symptoms and has shown to improve survival with
minimal late neurotoxicity. Reirradiation has conventionally been done
with whole brain radiotherapy, but now studies with stereotactic
radiosurgery have also shown promising results. In this review, we
focus on reirradiation as a treatment modality in such patients. We
performed a literature search in MEDLINE (www.pubmed.org) with key
words brain metastases, reirradiation, whole brain radiotherapy,
stereotactic radiosurgery, interstial brachytherapy, and brain. The
search was limited to the English literature and human subjects