Maligne bolesti kao uzrok smrti kod 92 skladatelja/glazbenika (uključujući ovisnosti)

This study shows malignant diseases as the main cause of death in composers. Pathographies are listed according to the chronological order of their occurrence. Composers in this study died of malignant diseases in the average age of 66.3 years, (median age 67, range 33-91 years). Unfortunately, one part of this heterogeneous group of composers lived too short, while most of them could realize their creative work. Nowadays many of these composers could be cured thanks to the development of medicine, better diagnostic procedures and treatment options, including more selective radiotherapy, chemotherapy, immunotherapy (monoclonal antibodies, specific target receptor or intracellular signal inhibitors).U ovom radu su prikazane maligne bolesti kao glavni uzrok smrti kod 92 skladatelja. Patografije su navedene kronološki. Prosječna dob smrti skladatelja u ovoj studiji je 66,3 godine (medijan dobi 67 godina, raspon 33-91 godine). Nažalost, značajan dio skladatelja nije mogao zbog malignih oboljenja dostići svoj stvaralački opus, dok je ipak većina dostigla stariju dob i stvaralački maksimum. U današnjici bi mnogi od ovih skladatelja mogli biti izliječeni zahvaljujući napretku suvremene medicine, boljim dijagnostičkim postupcima i terapijskim opcijama liječenja. To ponajprije podrazumijeva ciljanu terapiju poput selektivne kemoterapije, imunoterapije (monoklonska protutijela, specifično ciljani inhibitori staničnih receptora ili unutarstaničnih signalnih puteva)

LYMPHOMA DIAGNOSIS AND TREATMENT – SECOND CROATIAN CONSENSUS

Na sastanku održanom u ožujku 2012. godine na kojem su sudjelovali vodeći hrvatski stručnjaci donesene su nove, proširene i osuvremenjene preporuke o dijagnostici i liječenju limfoma. One obuhvaćaju morfološku, radiološku i nuklearnomedicinsku dijagnostiku, sustavno liječenje, radioterapiju i praćenje učinka liječenja najvećeg broja tumora limfocitne loze u odraslih osoba. Preporuke su donesene konsenzusom, na temelju izlaganja i prijedloga pojedinih stručnjaka koji su prvo raspravljeni unutar radnih skupina, a potom usuglašeni na plenarnom sastanku.New, extended and modernized recommendations for diagnostics and treatment of lymphomas were accepted at a meeting held in March 2012 with the participation of major Croatian experts. They encompass morphological, radiological and nuclear diagnostics, systemic treatment, radiotherapy and follow-up of most tumors of lymphoid tissues occurring in adults. The recommendations were agreed upon by consensus. Reporters presented data and suggested recommendations which had been first discussed in working groups and then agreed upon on the plenary session

Dijagnostika i liječenje limfoma - drugi hrvatski konsenzus [Lymphoma diagnosis and treatment - second Croatian consensus]

New, extended and modernized recommendations for diagnostics and treatment of lymphomas were accepted at a meeting held in March 2012 with the participation of major Croatian experts. They encompass morphological, radiological and nuclear diagnostics, systemic treatment, radiotherapy and follow-up of most tumors of lymphoid tissues occurring in adults. The recommendations were agreed upon by consensus. Reporters presented data and suggested recommendations which had been first discussed in working groups and then agreed upon on the plenary session

Leptomeningeal and intramedullary metastases of glioblastoma multiforme in a patient reoperated during adjuvant radiochemotherapy

Despite huge advances in medicine, glioblastoma multiforme (GBM) remains a highly lethal, fast-growing tumour that cannot be cured by currently available therapies. However, extracranial and extraneural dissemination of GBM is extremely rare, but is being recognised in different imaging studies. To date, the cause of the GBM metastatic spread still remains under discussion. It probably develops at the time of intracranial progression following a surgical procedure. According to other hypothesis, the metastases are a consequence of spontaneous tumour transdural extension or haematogenous dissemination. We present a case of a 59-year-old woman with symptomatic leptomeningeal and intramedullary metastases of GBM who has been previously surgically treated with primary subtotal resection and underwent a repeated surgery during adjuvant radiotherapy and chemotherapy with temozolomide. Today, the main goal of surgery and chemoradiotherapy is to prevent neurologic deterioration and improve health-related quality of life. With this paper, we want to present this rare entity and emphasise the importance of a multidisciplinary approach, a key function in the management of brain tumour patients. The prognosis is still very poor although prolongation of survival can be obtained. Finally, although rare, our case strongly suggests that clinicians should be familiar with the possibility of the extracranial spread of GBM because as treatment improvements provide better control of the primary tumour and improving survival, metastatic disease will be increasingly encountered