Identification of genes involved in alcohol consumption and cigarettes smoking

We compared the results of quantitative linkage analysis using single-nucleotide polymorphisms and microsatellite markers and introduced a new screening test for multivariate quantitative linkage analysis using the Collaborative Study on the Genetics of Alcoholism data. We analyzed 115 extended non-Hispanic White families and tested for linkage using two phenotypes: the maximum number of drinks in a 24-hour period and the number of packs smoked per day for one year. Our results showed that the linkage signal increased using single-nucleotide polymorphisms compared with microsatellite markers and that the screening test gave similar results to that of the bivariate analysis, suggesting its potential use in reducing overall analysis time

The Vascular-Renal Connection in Patients Hospitalized With Hypertensive Crisis: A Population-Based Study

Objective: To determine the risks of acute kidney injury development and long-term clinical outcomes of patients with hypertensive crisis. Patients and Methods: This was a population study of Olmsted County residents with hypertensive crisis between January 1, 2000, and December 31, 2008, with follow-up until June 30, 2016. Results: The results demonstrated that those with underlying chronic kidney disease upon admission for hypertensive crisis, defined as a systolic blood pressure above 180 mm Hg or diastolic blood pressure above 120 mm Hg, were more likely to develop acute kidney injury during hospitalization (odds ratio, 6.04; 95% CI, 1-26; P=.02). Hospitalization length of stay was increased when patients developed acute kidney injury during hypertensive crisis hospitalization (7.6±9 vs 3.4±4 days; P=.04). Furthermore, those who developed acute kidney injury had increased cardiac rehospitalization frequency over 10 years (87% vs 46%; P=.009). These results suggest that those with poor renal reserve are more likely to have further acute kidney damage in the setting of hypertensive crisis, likely due to decreased renal perfusion and neurohormonal dysregulation. Conclusion: In patients hospitalized for hypertensive crisis, chronic renal insufficiency was a risk factor associated with acute kidney injury development during hospitalization. Those who developed acute kidney injury had longer hospitalizations with increased rehospitalization frequency. Future studies are warranted to further investigate whether the preservation of renal function will improve clinical outcomes in hospitalized patients with hypertensive crisis

Multipoint results of bivariate linkage analysis and the screening test for sqrt(pakyrs) and sqrt(drink24)

<p><b>Copyright information:</b></p><p>Taken from "Identification of genes involved in alcohol consumption and cigarettes smoking"</p><p></p><p>BMC Genetics 2005;6(Suppl 1):S112-S112.</p><p>Published online 30 Dec 2005</p><p>PMCID:PMC1866826.</p><p></p

Comparison between SNP and microsatellite (MS) markers on chromosome 1 for the sqrt(pakyrs) and sqrt(drink24)

<p><b>Copyright information:</b></p><p>Taken from "Identification of genes involved in alcohol consumption and cigarettes smoking"</p><p></p><p>BMC Genetics 2005;6(Suppl 1):S112-S112.</p><p>Published online 30 Dec 2005</p><p>PMCID:PMC1866826.</p><p></p