6,122 research outputs found
Neural Interfaces: Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance (Adv. Funct. Mater. 3/2017)
Salvage Fractionated Stereotactic Re-irradiation (FSRT) for Patients with Recurrent High Grade Gliomas Progressed after Bevacizumab Treatment
Purpose/Objectives: Bevacizumab failure is a major clinical problem in the manage- ment of high grade gliomas (HGG), with a median overall survival of less than 4 months (m). This study evaluated the efficacy of fractionated stereotactic re-irradiation (FSRT) for patients with HGG after progression on Bevacizumab.
Materials/Methods: Retrospective review was conducted of patients treated with FSRT after progression on bevacizumab. A total of 36 patients were identified. FSRT was most commonly delivered in 3.5 Gy fractions to a total dose of 35 Gy. Survival from initial diagnosis, as well as from recurrence and re-irradiation, were utilized as study endpoints. Univariate and multivariate analysis was performed.
Results: Among the 36 patients, 31 patients had recurrent glioblastoma, and 5 patients had recurrent anaplastic astrocytoma. The median time from initial bevacizumab treatment to FSRT was 8.5 m (range 2.3 – 32.0 m). The median plan target volume for FSRT was 27.5 cc (range 1.95 – 165 cc). With a median follow up of 20.4 m, the overall survival of the patients since initial diagnosis was also 24.9 m. The median overall survival after initiation of bevacizumab was 13.4 months. The median overall survival from FSRT was 4.8 m. FSRT treatment was well tolerated with no Grade \u3e3 toxicity.
Conclusions: Favorable outcomes were observed in patients with recurrent HGG who received salvage FSRT after bevacizumab failure. The treatment was well tolerated. Prospective study is warranted to further evaluate the efficacy of salvage FSRT for selected patients with recurrent HGG amenable to FSRT, who had failed bevacizumab treatment
Holographic Bosonic Technicolor
We consider a technicolor model in which the expectation value of an
additional, possibly composite, scalar field is responsible for the generation
of fermion masses. We define the dynamics of the strongly coupled sector by
constructing its holographic dual. Using the AdS/CFT correspondence, we study
the S parameter and the phenomenology of the light technihadrons. We find that
the S parameter is small over a significant region of the model's parameter
space. The particle spectrum is distinctive and includes a nonstandard Higgs
boson as well as heavier hadronic resonances. Technihadron masses and decay
rates are calculated holographically, as a function of the model's parameters.Comment: 20 Pages, 4 eps figures, REVTex. Minor corrections and comments adde
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A fully hardware-based memristive multilayer neural network
Memristive crossbar arrays promise substantial improvements in computing throughput and power efficiency through in-memory analog computing. Previous machine learning demonstrations with memristive arrays, however, relied on software or digital processors to implement some critical functionalities, leading to frequent analog/digital conversions and more complicated hardware that compromises the energy efficiency and computing parallelism. Here, we show that, by implementing the activation function of a neural network in analog hardware, analog signals can be transmitted to the next layer without unnecessary digital conversion, communication, and processing. We have designed and built compact rectified linear units, with which we constructed a two-layer perceptron using memristive crossbar arrays, and demonstrated a recognition accuracy of 93.63% for the Modified National Institute of Standard and Technology (MNIST) handwritten digits dataset. The fully hardware-based neural network reduces both the data shuttling and conversion, capable of delivering much higher computing throughput and power efficiency
Complete Genome Sequence of Mesorhizobium ciceri bv. biserrulae Strain WSM1284, an Efficient Nitrogen-Fixing Microsymbiont of the Pasture Legume Biserrula pelecinus.
We report the complete genome sequence of Mesorhizobium ciceri bv. biserrulae strain WSM1284, a nitrogen-fixing microsymbiont of the pasture legume Biserrula pelecinus The genome consists of 6.88Â Mb distributed between a single chromosome (6.33Â Mb) and a single plasmid (0.55Â Mb)
Complete Genome Sequence of Mesorhizobium ciceri Strain CC1192, an Efficient Nitrogen-Fixing Microsymbiont of Cicer arietinum.
We report the complete genome sequence of Mesorhizobium ciceri strain CC1192, an efficient nitrogen-fixing microsymbiont of Cicer arietinum (chickpea). The genome consists of 6.94Â Mb distributed between a single chromosome (6.29Â Mb) and a plasmid (0.65Â Mb)
Image based magnetic field background correction for aortic and pulmonary artery flow measurement using phase contrast
Cosmological Simulations of the Preheating Scenario for Galaxy Cluster Formation: Comparison to Analytic Models and Observations
We perform a set of non--radiative cosmological simulations of a preheated
intracluster medium in which the entropy of the gas was uniformly boosted at
high redshift. The results of these simulations are used first to test the
current analytic techniques of preheating via entropy input in the smooth
accretion limit. When the unmodified profile is taken directly from
simulations, we find that this model is in excellent agreement with the results
of our simulations. This suggests that preheated efficiently smoothes the
accreted gas, and therefore a shift in the unmodified profile is a good
approximation even with a realistic accretion history. When we examine the
simulation results in detail, we do not find strong evidence for entropy
amplification, at least for the high-redshift preheating model adopted here. In
the second section of the paper, we compare the results of the preheating
simulations to recent observations. We show -- in agreement with previous work
-- that for a reasonable amount of preheating, a satisfactory match can be
found to the mass-temperature and luminosity-temperature relations. However --
as noted by previous authors -- we find that the entropy profiles of the
simulated groups are much too flat compared to observations. In particular,
while rich clusters converge on the adiabatic self--similar scaling at large
radius, no single value of the entropy input during preheating can
simultaneously reproduce both the core and outer entropy levels. As a result,
we confirm that the simple preheating scenario for galaxy cluster formation, in
which entropy is injected universally at high redshift, is inconsistent with
observations.Comment: 11 pages, 13 figures, accepted for publication in Ap
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