Protein-protein interaction (PPI) networks in the vasculome of mouse brain.

<p><b>A,</b> PPI network for leukocyte transendothelial migration. <b>B,</b> PPI network for the WNT signaling pathway. <b>C,</b> PPI network for adherence junctions. The expression levels of genes in the vasculome of mouse brain are indexed by color.</p

Expression of disease-related genes in the vasculome of mouse brain.

<p>Expression of disease-related genes in the vasculome of mouse brain.</p

Expression of plasma proteins in the vasculome of mouse brain.

<p>Note: *core is the intersect of all 4 independent data set. Lists of circulating proteins in human plasma were compiled from 4 different proteomic studies, then each study was overlapped with the expression profile of the brain vasculome. A core set of 387 proteins were defined as common proteins detected in all 4 human plasma protein studies. Out of the core set of plasma proteins, 100 proteins were expressed in the brain vasculome.</p

Enriched pathways detected in the vasculome of mouse brain.

<p>Note: Analysis based on brain endothelial specific genes in the mouse brain vasculome. These enriched pathways suggest that specific pathways and mechanisms are selectively enhanced in brain compared to heart and kidney glomerular vasculomes.</p

The vasculome of mouse brain is unique and different from those found in mouse heart and kidney.

<p>Heatmap for visualization of the expression levels of organ-specific endothelial genes across brain, heart and kidney glomeruli. X-axis represents individual samples and y-axis represents different genes. The expression levels of genes are indexed by color.</p

Angiogenesis networks.

<p><b>A</b>, Protein-protein interaction network for angiogenesis in the vasculome of mouse brain (including nearest neighbors). Circles for genes in angiogenesis and squares for the neighbor genes. The expression levels of genes in the vasculome of mouse brain are indexed by color. <b>B</b>, Heatmap comparison of expression profiles of genes in the VEGF signaling pathway from the vasculome of mouse brain, heart and kidney glomeruli. The expression levels of genes are indexed by color.</p