U.S.U and the New Toxicology

Toxicology, a branch of science once concerned only with poisons for their medical effects and legal con sequences, has undergone in recent years a metamorphosis on a major scale. The general field of toxicology is defined as the qualitative and quantitative study of the injurious effects of chemical agents, as detected by alterations of structure and function in living systems (Murphy and Hayes, 1972). In common with most other disciplines it has benefited from a growing sophistication in research methods and has particularly flourished in the wake of major advances in physiology, biochemistry and the other basic sciences that serve as its foundation. But, beyond this, the new toxicology has developed a particular character, scope and mission, which have completely transformed the old science and given rise to a new coinage-the term environmental toxicology. U.S.U. has been a rather steady participant in this transformation of toxicology through its long-standing research programs and more recent graduate training efforts. The intent in this paper is to examine the new toxicology and U.S.U.\u27s role in it with a view to the future prospects for bot

Southern California Edison SONGS ISFSI Project

Tu14a Addendum to 9-15-0228 - This addendum provides correspondence on the above-referenced staff report, ex parte communications, proposed revisions to the staff report, and staff’s response to comments. The proposed modifications to the staff report do not change staff’s recommendation that the Commission approve CDP # 9-15-0228, as conditioned

“Let’s Have a Chat:” Applying ChatGPT and Other Large Language Models to the Practice of Forensic Accounting

ChatGPT has captured the popular imagination because of its conversational voice, its wide scope of ‘knowledge’, and far-ranging abilities. In this paper, we use an innovative interview method to introduce CPAs to ChatGPT, its development, and the current state of its capabilities. We then draw upon our own expertise to discuss the evolution of large language models, suggest applications of large language models (LLMs) in the field of accounting, critically evaluate LLMs’ current strengths and weaknesses, and propose five principles to effectively and safely leverage LLMs in the accounting domain

Toward a Policy for Africa

https://egrove.olemiss.edu/citizens_clip/1114/thumbnail.jp

Problems of African Policy

https://egrove.olemiss.edu/citizens_clip/1101/thumbnail.jp

Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon γ

The immunosurveillance of transformed cells by the immune system remains one of the most controversial and poorly understood areas of immunity. Gene-targeted mice have greatly aided our understanding of the key effector molecules in tumor immunity. Herein, we describe spontaneous tumor development in gene-targeted mice lacking interferon (IFN)-γ and/or perforin (pfp), or the immunoregulatory cytokines, interleukin (IL)-12, IL-18, and tumor necrosis factor (TNF). Both IFN-γ and pfp were critical for suppression of lymphomagenesis, however the level of protection afforded by IFN-γ was strain specific. Lymphomas arising in IFN-γ-deficient mice were very nonimmunogenic compared with those derived from pfp-deficient mice, suggesting a comparatively weaker immunoselection pressure by IFN-γ. Single loss of IL-12, IL-18, or TNF was not sufficient for spontaneous tumor development. A significant incidence of late onset adenocarcinoma observed in both IFN-γ– and pfp-deficient mice indicated that some epithelial tissues were also subject to immunosurveillance

Flow convergence routing hypothesis for pool-riffle maintenance in alluvial rivers

The velocity reversal hypothesis is commonly cited as a mechanism for the maintenance of pool-riffle morphology. Although this hypothesis is based on the magnitude of mean flow parameters, recent studies have suggested that mean parameters are not sufficient to explain the dominant processes in many pool-riffle sequences. In this study, two- and three-dimensional models are applied to simulate flow in the pool-riffle sequence on Dry Creek, California, where the velocity reversal hypothesis was first proposed. These simulations provide an opportunity to evaluate the hydrodynamics underlying the observed reversals in near-bed and section-averaged velocity and are used to investigate the influence of secondary currents, the advection of momentum, and cross-stream flow variability. The simulation results support the occurrence of a reversal in mean velocity and mean shear stress with increasing discharge. However, the results indicate that the effects of flow convergence due to an upstream constriction and the routing of flow through the system are more significant in influencing pool-riffle morphology than the occurrence of a mean velocity reversal. The hypothesis of flow convergence routing is introduced as a more meaningful explanation of the mechanisms acting to maintain pool-riffle morphology