322 research outputs found
Maximum size binary matroids with no AG(3,2)-minor are graphic
We prove that the maximum size of a simple binary matroid of rank
with no AG(3,2)-minor is and characterise those matroids
achieving this bound. When , the graphic matroid is the
unique matroid meeting the bound, but there are a handful of smaller examples.
In addition, we determine the size function for non-regular simple binary
matroids with no AG(3,2)-minor and characterise the matroids of maximum size
for each rank
Teachers Learn About ADHD on the Web: An Online Graduate Special Education Course
This is the publisher's version, also found here: www.sped.orgDescribes several possibilities for using Internet-based applications to enhance teacher preparation to better serve students with attention-deficit/hyperactivity disorder (ADHD). Features of the Web-enhanced course, The Learner with ADHD which offers a general introduction to characteristics, treatment and education of students with ADHD. INSETS: Perspectives on distance learning; WebCT-an online course tool
Lung Malignancy in Prostate Cancer: a Report of Both Metastatic and Primary Lung Lesions
Prostate cancer is the most common non-cutaneous malignancy diagnosed in men. When it metastasizes, it usually spreads to bone and/or lymph nodes. A handful of cases have described prostatic metastases to the lung; however, this is usually in the setting of existing bone lesions. Here we describe a unique case in which a patient was found to have both metastatic prostate cancer to the lung and a primary lung cancer in the absence of any other evidence of extra-prostatic disease
Viral hepatitis testing and treatment in community pharmacies:a systematic review and meta-analysis
Background: The World Health Organization seeks to eliminate viral hepatitis as a public health threat by 2030. This review and meta-analysis aims to evaluate the effectiveness of programs for hepatitis B and C testing and treatment in community pharmacies. Methods: Medline, Embase, Cochrane CENTRAL, and Global Health were searched from database inception until 12 November 2023. Comparative and single arm intervention studies were eligible for inclusion if they assessed delivery of any of the following interventions for hepatitis B or C in pharmacies: (1) pre-testing risk assessment, (2) testing, (3) pre-treatment assessment or (4) treatment. Primary outcomes were proportions testing positive and reaching each stage in the cascade. Random effects meta-analysis was used to estimate pooled proportions stratified by recruitment strategy and setting where possible; other results were synthesised narratively. This study was pre-registered (PROSPERO: CRD42022324218). Findings: Twenty-seven studies (4 comparative, 23 single arm) were included, of which 26 reported hepatitis C outcomes and four reported hepatitis B outcomes. History of injecting drug use was the most identified risk factor from pre-testing risk assessments. The pooled proportion hepatitis C antibody positive from of 19 studies testing 5096 participants was 16.6% (95% CI 11.0%β23.0%; heterogeneity I 2 = 96.6%). The pooled proportion antibody positive was significantly higher when testing targeted people with specified risk factors (32.5%, 95% CI 24.8%β40.6%; heterogeneity I 2 = 82.4%) compared with non-targeted or other recruitment methods 4.0% (95% CI 2.1%β6.5%; heterogeneity I 2 = 83.5%). Meta-analysis of 14 studies with 813 participants eligible for pre-treatment assessment showed pooled attendance rates were significantly higher in pharmacies (92.7%, 95% CI 79.1%β99.9%; heterogeneity I 2 = 72.4%) compared with referral to non-pharmacy settings (53.5%, 95% CI 36.5%β70.1%; heterogeneity I 2 = 92.3%). The pooled proportion initiating treatment was 85.6% (95% CI 74.8%β94.3%; heterogeneity I 2 = 75.1%). This did not differ significantly between pharmacy and non-pharmacy settings. Interpretation: These findings add pharmacies to the growing evidence supporting community-based testing and treatment for hepatitis C. Few comparative studies and high degrees of statistical heterogeneity were important limitations. Hepatitis B care in pharmacies presents an opportunity for future research. Funding: None.</p
Cosmicflows-4
With Cosmicflows-4, distances are compiled for 55,877 galaxies gathered into
38,065 groups. Eight methodologies are employed, with the largest numbers
coming from the correlations between the photometric and kinematic properties
of spiral galaxies (TF) and elliptical galaxies (FP). Supernovae that arise
from degenerate progenitors (SNIa) are an important overlapping component.
Smaller contributions come from distance estimates from the surface brightness
fluctuations of elliptical galaxies (SBF) and the luminosities and expansion
rates of core collapse supernovae (SNII). Cepheid Period-Luminosity Relation
(CPLR) and Tip of the Red Giant Branch (TRGB) observations founded on local
stellar parallax measurements along with the geometric maser distance to NGC
4258 provide the absolute scaling of distances. The assembly of galaxies into
groups is an important feature of the study in facilitating overlaps between
methodologies. Merging between multiple contributions within a methodology and
between methodologies is carried out with Bayesian Markov chain Monte Carlo
procedures. The final assembly of distances is compatible with a value of the
Hubble constant of km s Mpc with the small statistical
error km s Mpc but a large potential systematic error
~3 km s Mpc. Peculiar velocities can be inferred from the
measured distances. The interpretation of the field of peculiar velocities is
complex because of large errors on individual components and invites analyses
beyond the scope of this study.Comment: 38 pages, 24 figures. catalogs available at edd.ifa.hawaii.edu.
Accepted to Ap
Allogeneic Hematopoietic Cell Transplantation Improves Outcome in Myelodysplastic Syndrome Across High-Risk Genetic Subgroups:Genetic Analysis of the Blood and Marrow Transplant Clinical Trials Network 1102 Study
PURPOSE:Allogeneic hematopoietic cell transplantation (HCT) in patients with myelodysplastic syndrome (MDS) improves overall survival (OS). We evaluated the impact of MDS genetics on the benefit of HCT in a biological assignment (donor v no donor) study.METHODS:We performed targeted sequencing in 309 patients age 50-75 years with International Prognostic Scoring System (IPSS) intermediate-2 or high-risk MDS, enrolled in the Blood and Marrow Transplant Clinical Trials Network 1102 study and assessed the association of gene mutations with OS. Patients with TP53 mutations were classified as TP53multihit if two alleles were altered (via point mutation, deletion, or copy-neutral loss of heterozygosity).RESULTS:The distribution of gene mutations was similar in the donor and no donor arms, with TP53 (28% v 29%; P =.89), ASXL1 (23% v 29%; P =.37), and SRSF2 (16% v 16%; P =.99) being most common. OS in patients with a TP53 mutation was worse compared with patients without TP53 mutation (21% Β± 5% [SE] v 52% Β± 4% at 3 years; P <.001). Among those with a TP53 mutation, OS was similar between TP53single versus TP53multihit (22% Β± 8% v 20% Β± 6% at 3 years; P =.31). Considering HCT as a time-dependent covariate, patients with a TP53 mutation who underwent HCT had improved OS compared with non-HCT treatment (OS at 3 years: 23% Β± 7% v 11% Β± 7%; P =.04), associated with a hazard ratio of 3.89; 95% CI, 1.87 to 8.12; P <.001 after adjustment for covariates. OS among patients with molecular IPSS (IPSS-M) very high risk without a TP53 mutation was significantly improved if they had a donor (68% Β± 10% v 0% Β± 12% at 3 years; P =.001).CONCLUSION:HCT improved OS compared with non-HCT treatment in patients with TP53 mutations irrespective of TP53 allelic status. Patients with IPSS-M very high risk without a TP53 mutation had favorable outcomes when a donor was available.</p
Impaired Functions of Peripheral Blood Monocyte Subpopulations in Aged Humans
Aging is associated with increased susceptibility to microbial infections, and monocytes play an important role in microbial defense. In this study, we have identified and compared four subpopulations of monocytes (CD14++(high)CD16β, CD14+(low)CD16β, CD14++(high)CD16+, and CD14+(low)CD16+) in the peripheral blood of young and aged subjects with regard to their numbers, cytokine production, TLR expression, and phosphorylation of ERK1/2 in response to pam3Cys a TLR-1/2 ligand. Proportions and numbers of CD14++(high)CD16+ and CD14+(low)CD16+ monocytes were significantly increased, whereas proportions of CD14+(low)CD16β monocytes were decreased in aged subjects as compared to young subjects. In aged subjects, IL-6 production by all four subsets of monocytes was significantly decreased, whereas TNF-Ξ± production was decreased in monocyte subsets, except the CD14+(low)CD16β subset. A significantly reduced expression of TLR1 was observed in CD14++(high)CD16+ and CD14+(low)CD16+ monocyte subsets in aged subjects. Furthermore, following pam3Cys stimulation, ERK1/2 phosphorylation was significantly lower in CD14+(low)CD16+, CD14++(high)CD16+, and CD14+(low)CD16β subsets of monocytes from aged subjects. This is the first study of four subpopulations of monocytes in aging, which demonstrates that their functions are differentially impaired with regard to the production of cytokines, expression of TLR, and signaling via the ERKβMAPK pathway. Finally, changes in the number of monocyte subsets, and impairment of TLR1 expression, TNF-Ξ± production, and EK1/2 phosphorylation was more consistent in CD16+ monocyte subsets regardless of expression of CD14high or CD14+low, therefore highlighting the significance of further subdivision of monocytes into four subpopulations
Sub-micron proximal probe thermal desorption and laser mass spectrometry on painting cross-sections
Cross-sections containing organic dyes are used to demonstrate sub-micron atomic force microscopy thermal desorption (AFM-TD), followed by laser mass spectrometry
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