Antibodies to Wb123 fail to normalize following definitive anti-filarial treatment.

<p>IgG (Top panel) and IgG4 (Middle panel) anti-Wb123 antibodies in two individual patients followed longitudinally over an 8 (red line) or 17 (blue line) year period following definitive anti-filarial chemotherapy. Circulating antigen levels in the same two subjects is shown (Bottom panel). Gray shaded boxes show the normal range for each assay.</p

Performance of Wb123-specific IgG LIPS assay in blinded analysis.

<p>Blinded analysis of IgG anti-Wb123 antibodies from samples obtained from <i>Wuchereria bancrofti</i>-infected patients from Haiti (Haiti MF pos), those from a Wb non-endemic region of Haiti (Haiti non-exposed), US non-travelers, those with other non-filarial parasitic infection, or those with <i>Brugia malayi</i> infection. Each dot represents an individual subject and the horizontal line is the GM. The dashed line represents the cutoff between negative and positive based on ROC analysis.</p

Samples used to assess sensitivity and specificity of Wb123 LIPS.

*<p>Circulating antigen negative.</p

Sensitivity and specificity of Wb123 IgG and IgG4 LIPS.

*<p>Calculations (Sensitivity, Specificity, PPV, NPV) are shown when the positive was defined as sera from proven <i>Wuchereria bancrofti</i> infection and the negative was defined as either normal (Normals), <i>Loa loa</i>-infected (<i>L. loa</i>). <i>Onchocera volvulus</i>-infected (O. <i>volvulus)</i>, <i>Mansonella perstans</i>-infected (<i>M. perstans</i>) or infected with soil transmitted helminths (Other Helminths).</p><p>ND = not done.</p>**<p>Positive Predictive Value.</p>***<p>Negative Predictive Value.</p

Prevalence of Ab to Wb123 in CAg− individuals.

<p>Percent prevalence (y-axis) of Ab to Wb123 by age group (x-axis) in CAg− individuals on Mauke from 1975 (red line) and 1992 (blue line). Asterisks represent a significant difference (p≤0.04; Fisher's exact test) between the prevelances in 1975 and 1992 within a given age group.</p