Subacute Sclerosing Panencephalitis of the Brainstem as a Clinical Entity.

Subacute sclerosing panencephalitis (SSPE) is a rare progressive neurological disorder of early adolescence caused by persistent infection of the measles virus, which remains prevalent worldwide despite an effective vaccine. SSPE is a devastating disease with a characteristic clinical course in subcortical white matter; however, atypical presentations of brainstem involvement may be seen in rare cases. This review summarizes reports to date on brainstem involvement in SSPE, including the clinical course of disease, neuroimaging presentations, and guidelines for treatment. A comprehensive literature search was performed for English-language publications with keywords "subacute sclerosing panencephalitis" and "brainstem" using the National Library of Medicine PubMed database (March 1981-September 2017). Eleven articles focusing on SSPE of the brainstem were included. Predominant brainstem involvement remains uncharacteristic of SSPE, which may lead to misdiagnosis and poor outcome. A number of case reports have demonstrated brainstem involvement associated with other intracranial lesions commonly presenting in later SSPE stages (III and IV). However, brainstem lesions can appear in all stages, independent of higher cortical structures. The varied clinical presentations complicate diagnosis from a neuroimaging perspective. SSPE of the brainstem is a rare but important clinical entity. It may present like canonical SSPE or with unique clinical features such as absence seizures and pronounced ataxia. While SSPE generally progresses to the brainstem, it can also begin with a primary focus of infection in the brainstem. Awareness of varied SSPE presentations can aid in early diagnosis as well as guide management and treatment

SPATIAL ANALYSIS OF FEEDER CATTLE HEDGING RISK

Optimal hedge ratios are estimated for various weights of feeder cattle in four cash markets based on CME data from 1992 to 1999. Three-month uniform hedges are simulated for every weight, contract, and cash market combination. Hedging effectiveness is compared empirically across locations to identify spatial differences in hedging risk.feeder cattle, hedging risk, hedge ratios, Livestock Production/Industries, Risk and Uncertainty,

OPTIMAL HEDGING RATIOS AND HEDGING RISK FOR GRAIN BY-PRODUCTS

Optimal cross hedge ratios are estimated for a number of grain by-products used as livestock feed. Risk associated with these cross hedge ratios is measured to determine if cross hedging reduces grain by-product price risk. Results provide useful risk management guidelines for livestock and dairy producers.Marketing,

Coherence in logical quantum channels

We study the effectiveness of quantum error correction against coherent noise. Coherent errors (for example, unitary noise) can interfere constructively, so that in some cases the average infidelity of a quantum circuit subjected to coherent errors may increase quadratically with the circuit size; in contrast, when errors are incoherent (for example, depolarizing noise), the average infidelity increases at worst linearly with circuit size. We consider the performance of quantum stabilizer codes against a noise model in which a unitary rotation is applied to each qubit, where the axes and angles of rotation are nearly the same for all qubits. In particular, we show that for the toric code subject to such independent coherent noise, and for minimal-weight decoding, the logical channel after error correction becomes increasingly incoherent as the length of the code increases, provided the noise strength decays inversely with the code distance. A similar conclusion holds for weakly correlated coherent noise. Our methods can also be used for analyzing the performance of other codes and fault-tolerant protocols against coherent noise. However, our result does not show that the coherence of the logical channel is suppressed in the more physically relevant case where the noise strength is held constant as the code block grows, and we recount the difficulties that prevented us from extending the result to that case. Nevertheless our work supports the idea that fault-tolerant quantum computing schemes will work effectively against coherent noise, providing encouraging news for quantum hardware builders who worry about the damaging effects of control errors and coherent interactions with the environment

Coherence in logical quantum channels

We study the effectiveness of quantum error correction against coherent noise. Coherent errors (for example, unitary noise) can interfere constructively, so that in some cases the average infidelity of a quantum circuit subjected to coherent errors may increase quadratically with the circuit size; in contrast, when errors are incoherent (for example, depolarizing noise), the average infidelity increases at worst linearly with circuit size. We consider the performance of quantum stabilizer codes against a noise model in which a unitary rotation is applied to each qubit, where the axes and angles of rotation are nearly the same for all qubits. In particular, we show that for the toric code subject to such independent coherent noise, and for minimal-weight decoding, the logical channel after error correction becomes increasingly incoherent as the length of the code increases, provided the noise strength decays inversely with the code distance. A similar conclusion holds for weakly correlated coherent noise. Our methods can also be used for analyzing the performance of other codes and fault-tolerant protocols against coherent noise. However, our result does not show that the coherence of the logical channel is suppressed in the more physically relevant case where the noise strength is held constant as the code block grows, and we recount the difficulties that prevented us from extending the result to that case. Nevertheless our work supports the idea that fault-tolerant quantum computing schemes will work effectively against coherent noise, providing encouraging news for quantum hardware builders who worry about the damaging effects of control errors and coherent interactions with the environment.Comment: 113 pages, 21 figures. Corrected typos, added references, and added subsections 1.2 and 1.3 (v2

Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2.

Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic development and vulval morphogenesis. However, assignment of these functions to specific proteoglycans has been limited by the lack of identified core proteins. We used a combination of biochemical purification, Western blotting, and mass spectrometry to identify nine C. elegans chondroitin proteoglycan core proteins, none of which have homologues in vertebrates or other invertebrates such as Drosophila melanogaster or Hydra vulgaris. CPG-1/CEJ-1 and CPG-2 are expressed during embryonic development and bind chitin, suggesting a structural role in the egg. RNA interference (RNAi) depletion of individual CPGs had no effect on embryonic viability, but simultaneous depletion of CPG-1/CEJ-1 and CPG-2 resulted in multinucleated single-cell embryos. This embryonic lethality phenocopies RNAi depletion of the SQV-5 chondroitin synthase, suggesting that chondroitin chains on these two proteoglycans are required for cytokinesis