Determinants of knowledge mapping adoption in software maintenance

Knowledge Maps (KMaps) could be ideally suited for resolving many of the traceability problems in computer software maintenance. This thesis provides an understanding of the various factors that will encourage or impede the software maintenance community to adopt KMaps as part of their process. ABC Company in Perth, Western Australia, was chosen as the research site because it is a multinational software development company with customers in many major cities around the world. Since Knowledge Mapping (KMapping) is relatively new to most software staffers, it was necessary to develop a Software Maintenance KMap prototype. A literature review of KMapping, innovation adoption/diffusion theories and the review of three KMapping case studies determined the factors used to develop the theoretical model and guided the design of the prototype. To evaluate attitudes to the adoption of the prototype, the researcher adopted the interpretive research approach, justifying his decision by using Chua’s (1986) three sets of beliefs to ‘delineate a way of seeing and researching the world’. Nineteen interviews were conducted and analysed through NVivoTM software and according to the steps in ‘Carney’s Letter of Analytical Abstraction’. Encouragement factors were found to be those that management has direct control over such as the planning for the communication and promotion of KMapping, the appointment of a management champion, the allocation of resources and time to the KMapping project and the planning for appropriate rewards and incentive programmes. As for the impeding factors, these were factors that related to what staffers thought of the quality of the results or data links in the KMaps and included such factors as the existence of inadequate or inappropriate data and poor configuration management. Adoption factors formed the basis from which the study’s explanatory framework, named the KMapping Adoption Model (KAM), was synthesised. In addition, the study makes recommendations of push and pull strategies, integrated into KAM, to managers who are planning to introduce KMapping into their organisations. The thesis concludes with a recognition of the study’s limitations and suggestions for future research

Frequently asked questions on measurement of bone mineral densitometry

DXA is a fast, reliable, low-radiation method for assessing BMD, which is the arbiter for osteoporosis treatment eligibility and the best determinant of future fracture risk. • Web-based fracture risk calculators can utilise BMD data to provide further information for medical practitioners and patients. • The interval for serial BMD assessment for detecting development of osteoporosis should be planned according to the previous DXA findings

Public health and economic costs of investigating a suspected outbreak of Legionnaires' disease.

This paper provides one of the first assessments of the burden of both the public health investigation and the economic costs associated with an apparent outbreak of Legionnaires' disease (LD) in South East London. In addition to epidemiological, microbiological and environmental investigations, we collected data on the staff time and resources committed by the 11 main organizations responsible for managing the outbreak. Of the overall estimated costs of 455,856 pounds, only 14% (64,264 pounds) was spent on investigation and control of the outbreak compared with 86% (391,592 pounds) spent on the hospital treatment of the patients. The time and money spent on public health services in this investigation appear to represent good value for money considering the potential costs of a major outbreak, including the high case-fatality rate in LD generally and the high health-care costs. Further research is needed to determine optimum strategies for the cost-effective use of health system resources in investigations of LD. Whether the threshold for investigation of cases should be based on observed incidence rates or the cost-effectiveness of investigations, or both, should be debated further

Evaluation of the wind farm parameterization in the Weather Research and Forecasting model (version 3.8.1) with meteorological and turbine power data

Abstract. Forecasts of wind power production are necessary to facilitate the integration of wind energy into power grids, and these forecasts should incorporate the impact of wind turbine wakes. This paper focuses on a case study of four diurnal cycles with significant power production, and assesses the skill of the wind farm parameterization (WFP) distributed with the Weather Research and Forecasting (WRF) model version 3.8.1, as well as its sensitivity to model configuration. After validating the simulated ambient flow with observations, we quantify the value of the WFP as it accounts for wake impacts on power production of downwind turbines. We also illustrate that a vertical grid with nominally 12-m vertical resolution is necessary for reproducing the observed power production, with statistical significance. Further, the WFP overestimates wake effects and hence underestimates downwind power production during high wind speed and low turbulence conditions. We also find the WFP performance is independent of atmospheric stability, the number of wind turbines per model grid cell, and the upwind-downwind position of turbines. Rather, the ability of the WFP to predict power production is most dependent on the skill of the WRF model in simulating the ambient wind speed. </jats:p

China and India: Globalization with Different Paths

This occasional paper has three essays written by professors from Pace University and Nanjing Normal University that address a host of structural challenges facing China and India in pursuit of sustainable development in the early twenty-first century. Pan Zhen gives a critical overview of China’s economic policies, and finds the top-down development model to be fraught with tensions. Joseph Tse-Hei Lee argues that the ability of China to pursue sustainable growth and social betterment is largely contingent upon many circumstantial factors, especially the negative attributes of globalization and the rise of domestic discontents. Satish K. Kolluri shifts the focus of discussion to the electoral victory of Narendra Modi in India, and examines the implications of the rise of Modi in domestic and regional politics. These essays throw light on the political and socioeconomic trajectories of China and India. Since both countries have significantly liberalized their economies in recent decades, the unprecedented expansion of their capabilities and influences is a complex phenomenon, rooted in the context of particular temporal and spatial settings, and the need to accommodate endogenous and exogenous forces of change

Moving Forward: Advances in the Treatment of Movement Disorders with Deep Brain Stimulation

The modern era of stereotactic and functional neurosurgery has ushered in state of the art technologies for the treatment of movement disorders, particularly Parkinson’s disease (PD), tremor, and dystonia. After years of experience with various surgical therapies, the eventual shortcomings of both medical and surgical treatments, and several serendipitous discoveries, deep brain stimulation (DBS) has risen to the forefront as a highly effective, safe, and reversible treatment for these conditions. Idiopathic advanced PD can be treated with thalamic, globus pallidus internus (GPi), or subthalamic nucleus (STN) DBS. Thalamic DBS primarily relieves tremor while GPi and STN DBS alleviate a wide range of Parkinsonian symptoms. Thalamic DBS is also used in the treatment of other types of tremor, particularly essential tremor, with excellent results. Both primary and various types of secondary dystonia can be treated very effectively with GPi DBS. The variety of anatomical targets for these movement disorders is indicative of the network-level dysfunction mediating these movement disturbances. Despite an increasing understanding of the clinical benefits of DBS, little is known about how DBS can create such wide sweeping neuromodulatory effects. The key to improving this therapeutic modality and discovering new ways to treat these and other neurologic conditions lies in better understanding the intricacies of DBS. Here we review the history and pertinent clinical data for DBS treatment of PD, tremor, and dystonia. While multiple regions of the brain have been targeted for DBS in the treatment of these movement disorders, this review article focuses on those that are most commonly used in current clinical practice. Our search criteria for PubMed included combinations of the following terms: DBS, neuromodulation, movement disorders, PD, tremor, dystonia, and history. Dates were not restricted

Prevalence of clinically actionable disease variants in exceptionally long-lived families

BACKGROUND: Phenotypic expression of pathogenic variants in individuals with no family history of inherited disorders remains unclear. METHODS: We evaluated the prevalence of pathogenic variants in 25 genes associated with Mendelian-inherited disorders in 3015 participants from 485 families in the Long Life Family Study (LLFS). Boot-strapping and Fisher\u27s exact test were used to determine whether allele frequencies in LLFS were significantly different from the allele frequencies reported in publicly available genomic databases. RESULTS: The proportions of pathogenic autosomal dominant mutation carriers in BRCA1 and SDHC in LLFS study participants were similar to those reported in publicly available genomic databases (0.03% vs. 0.0008%, p = 1 for BRCA1, and 0.08% vs. 0.003%, p = 0.05 for SDHC). The frequency of carriers of pathogenic autosomal recessive variants in CPT2, ACADM, SUMF1, WRN, ATM, and ACADVL were also similar in LLFS as compared to those reported in genomic databases. The lack of clinical disease among LLFS participants with well-established pathogenic variants in BRCA1 and SDHC suggests that penetrance of pathogenic variants may be different in long lived families. CONCLUSION: Further research is needed to better understand the penetrance of pathogenic variants before expanding large scale genomic testing to asymptomatic individuals