Nature Versus Nurture: Luminous Blue Variable Nebulae in and near Massive Stellar Clusters at the Galactic Center

Three Luminous Blue Variables (LBVs) are located in and near the Quintuplet Cluster at the Galactic Center: the Pistol star, G0.120-0.048, and qF362. We present imaging at 19, 25, 31, and 37 {\mu}m of the region containing these three LBVs, obtained with SOFIA using FORCAST. We argue that the Pistol and G0.120-0.048 are identical ``twins" that exhibit contrasting nebulae due to the external influence of their different environments. Our images reveal the asymmetric, compressed shell of hot dust surrounding the Pistol Star and provide the first detection of the thermal emission from the symmetric, hot dust envelope surrounding G0.120-0.048. Dust and gas composing the Pistol nebula are primarily heated and ionized by the nearby Quintuplet Cluster stars. The northern region of the Pistol nebula is decelerated due to the interaction with the high-velocity (2000 km/s) winds from adjacent Wolf-Rayet Carbon (WC) stars. With the DustEM code we determine that the Pistol nebula is composed of a distribution of very small, transiently-heated grains (10-~35 {\AA}) and that it exhibits a gradient of decreasing grain size from the south to the north due to differential sputtering by the winds from the WC stars. Dust in the G0.120-0.048 nebula is primarily heated by the central star; however, the nebular gas is ionized externally by the Arches Cluster. Unlike the Pistol nebula, the G0.120-0.048 nebula is freely expanding into the surrounding medium. Given independent dust and gas mass estimates we find that the Pistol and G0.120-0.048 nebulae exhibit similar gas-to-dust mass ratios of ~310 and ~290, respectively. Both nebulae share identical size scales (~ 0.7 pc) which suggests that they have similar dynamical timescales of ~10^5 yrs, assuming a shell expansion velocity of v_exp 60 km/s.Comment: 18 pages, 7 figures, accepted to Ap

Closed Quasi-Fuchsian Surfaces In Hyperbolic Knot Complements

We show that every hyperbolic knot complement contains a closed quasi-Fuchsian surface.Comment: 69 pages, 27 figures. Made small changes suggested by refere

Old supernova dust factory revealed at the Galactic center

Dust formation in supernova ejecta is currently the leading candidate to explain the large quantities of dust observed in the distant, early Universe. However, it is unclear whether the ejecta-formed dust can survive the hot interior of the supernova remnant (SNR). We present infrared observations of ~0.02 $M_\odot$ of warm (~100 K) dust seen near the center of the ~10,000 yr-old Sgr A East SNR at the Galactic center. Our findings signify the detection of dust within an older SNR that is expanding into a relatively dense surrounding medium ($n_e$ ~ 100 $\mathrm{cm}^{-3}$) and has survived the passage of the reverse shock. The results suggest that supernovae may indeed be the dominant dust production mechanism in the dense environment of early Universe galaxies.Comment: 25 pages, 5 figures. Includes supplementary materials. Published Online March 19 2015 on Science Expres

First Science Results From SOFIA/FORCAST: Super-Resolution Imaging of the S140 Cluster at 37\micron

We present 37\micron\ imaging of the S140 complex of infrared sources centered on IRS1 made with the FORCAST camera on SOFIA. These observations are the longest wavelength imaging to resolve clearly the three main sources seen at shorter wavelengths, IRS 1, 2 and 3, and are nearly at the diffraction limit of the 2.5-m telescope. We also obtained a small number of images at 11 and 31\micron\ that are useful for flux measurement. Our images cover the area of several strong sub-mm sources seen in the area -- SMM 1, 2, and 3 -- that are not coincident with any mid-infrared sources and are not visible in our longer wavelength imaging either. Our new observations confirm previous estimates of the relative dust optical depth and source luminosity for the components in this likely cluster of early B stars. We also investigate the use of super-resolution to go beyond the basic diffraction limit in imaging on SOFIA and find that the van Cittert algorithm, together with the "multi-resolution" technique, provides excellent results

The Ursinus Weekly, February 24, 1941

Kathryn Boghetti gives brilliant performance in contralto recital • Purity of the heart is vespers theme • Hitchler describes wide opportunities in law • Buck Hills conference to be held March 7-9 • Atkinson, Howarth and Scott nominated for May queen contest • Pre-meds to hear talk by Ursinus graduate • G. Adams raised to editorial staff by \u27Weekly\u27 board • Ursinus debaters travel • Women debate \u27plan for union\u27 with Moravian • Beware Joe Louis! Ursinus boxers show great ability for coming intramurals • Co-eds bag 138 braves at Indian motif Lorelei • Byron, Patterson to speak at meeting of IRC Tuesday • Ken Hashagen came to Ursinus via many honors at Penn • A.A.U.W. will consider national defense at Freeland dinner • Gettysburg tosses varsity wrestlers; cubs are pinned by Mercersburg • Varsity court team loses two contests on week-end trip • Freshman quintet loses to Diplomats by 32-30 • Bears wilt in second half: lose to Diplomats, 41-27 • Frosh triumph 48-34 over Norristown YMCAhttps://digitalcommons.ursinus.edu/weekly/1809/thumbnail.jp

Pre- and post- prandial appetite hormone levels in normal weight and severely obese women

<p>Abstract</p> <p>Background</p> <p>Appetite is affected by many factors including the hormones leptin, ghrelin and adiponectin. Ghrelin stimulates hunger, leptin promotes satiety, and adiponectin affects insulin response. This study was designed to test whether the pre- and postprandial response of key appetite hormones differs in normal weight (NW) and severely obese (SO) women.</p> <p>Methods</p> <p>Twenty three women ages 25–50 were recruited for this study including 10 NW (BMI = 23.1 ± 1.3 kg/m²) and 13 SO (BMI = 44.5 ± 7.1 kg/m²). The study was conducted in a hospital-based clinical research centre. Following a 12-hour fast, participants had a baseline blood draw, consumed a moderately high carbohydrate meal (60% carbohydrate, 20% protein, 20% fat) based on body weight. Postprandially, participants had six blood samples drawn at 0, 15, 30, 60, 90, and 120 minutes. Primary measures included pre- and post-prandial total ghrelin, leptin, adiponectin and insulin. A repeated measures general linear model was used to evaluate the hormone changes by group and time (significance p ≤ 0.05).</p> <p>Results</p> <p>There were significant differences between the NW and the SO for all hormones in the preprandial fasting state. The postprandial responses between the SO versus NW revealed: higher leptin (p < 0.0001), lower adiponectin (p = 0.04), trend for lower ghrelin (p = 0.06) and insulin was not different (p = 0.26). Postprandial responses over time between the SO versus NW: higher leptin (p < 0.001), lower ghrelin and adiponectin (p = 0.004, p = 0.015, respectively), and trend for higher insulin (p = 0.06).</p> <p>Conclusion</p> <p>This study indicates that significant differences in both pre- and selected post- prandial levels of leptin, ghrelin, adiponectin and insulin exist between NW and SO women. Improving our understanding of the biochemical mechanisms accounting for these differences in appetite hormones among individuals with varying body size and adiposity should aid in the development of future therapies to prevent and treat obesity.</p

Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12.

Innate lymphoid cells (ILCs) are tissue-resident sentinels that are essential for early host protection from pathogens at initial sites of infection. However, whether pathogen-derived antigens directly modulate the responses of tissue-resident ILCs has remained unclear. In the present study, it was found that liver-resident type 1 ILCs (ILC1s) expanded locally and persisted after the resolution of infection with mouse cytomegalovirus (MCMV). ILC1s acquired stable transcriptional, epigenetic and phenotypic changes a month after the resolution of MCMV infection, and showed an enhanced protective effector response to secondary challenge with MCMV consistent with a memory lymphocyte response. Memory ILC1 responses were dependent on the MCMV-encoded glycoprotein m12, and were independent of bystander activation by proinflammatory cytokines after heterologous infection. Thus, liver ILC1s acquire adaptive features in an MCMV-specific manner

SOFIA/FORCAST and Spitzer/IRAC Imaging of the Ultra Compact H II Region W3(OH) and Associated Protostars in W3

We present infrared observations of the ultra-compact H II region W3(OH) made by the FORCAST instrument aboard SOFIA and by Spitzer/IRAC. We contribute new wavelength data to the spectral energy distribution, which constrains the optical depth, grain size distribution, and temperature gradient of the dusty shell surrounding the H II region. We model the dust component as a spherical shell containing an inner cavity with radius ~ 600 AU, irradiated by a central star of type O9 and temperature ~ 31,000 K. The total luminosity of this system is 71,000 L_solar. An observed excess of 2.2 - 4.5 microns emission in the SED can be explained by our viewing a cavity opening or clumpiness in the shell structure whereby radiation from the warm interior of the shell can escape. We claim to detect the nearby water maser source W3 (H2O) at 31.4 and 37.1 microns using beam deconvolution of the FORCAST images. We constrain the flux densities of this object at 19.7 - 37.1 microns. Additionally, we present in situ observations of four young stellar and protostellar objects in the SOFIA field, presumably associated with the W3 molecular cloud. Results from the model SED fitting tool of Robitaille et al. (2006, 2007} suggest that two objects (2MASS J02270352+6152357 and 2MASS J02270824+6152281) are intermediate-luminosity (~ 236 - 432 L_solar) protostars; one object (2MASS J02270887+6152344) is either a high-mass protostar with luminosity 3000 L_solar or a less massive young star with a substantial circumstellar disk but depleted envelope; and one object (2MASS J02270743+6152281) is an intermediate-luminosity (~ 768 L_solar) protostar nearing the end of its envelope accretion phase or a young star surrounded by a circumstellar disk with no appreciable circumstellar envelope.Comment: 12 pages, 8 figures, 2 tables, accepted by Ap

Regulation of the Epstein-Barr virus DNA polymerase gene.

The gene (pol) encoding the Epstein-Barr virus (EBV) DNA polymerase is a member of the "early" class of viral genes which are expressed shortly after activation of latent virus infection. First, mRNA from the EBV-producing cell line, B95-8, treated with 12-O-tetradecanoylphorbol-13-acetate and sodium butyrate to induce lytic replication and expression of this gene was analyzed. Northern (RNA) analysis revealed a message of 3.7 kb found only in induced cells. 5' mapping of pol mRNA by S1 nuclease and primer extension analyses indicates that transcription initiates at tightly clustered sites within a G + C-rich region 126 bp upstream of the open reading frame. The same initiation region was identified in two other EBV-infected cell lines, P3HR1 and Raji, after induction. Second, a 1.29-kb genomic fragment containing this region, when cloned upstream of the chloramphenicol acetyltransferase reporter gene, demonstrated promoter activity in lymphoid cells cotransfected with pEBV-RZ, a genomic expression construct that includes genes for the EBV immediate-early transactivator proteins, BZLF-1 and BRLF-1. Within the upstream 1.29-kb sequence, two regions of 140 bp and 101 bp appear to be needed for promoter activity. These results demonstrate that unlike most EBV genes studied thus far, the pol gene contains multiple transcriptional start sites. The upstream regulatory region of the promoter for the pol gene does not contain canonical promoter elements such as TATA and CAAT boxes and, furthermore, is not constitutively active but requires transactivation by two or more viral proteins