The thermal simulation of an office building implementing a new behavioural algorithm for window opening and the use of ceiling fans

This investigation of the window opening data from extensive field surveys in UK office buildings investigates 1) how people control the indoor environment by opening windows, 2) the cooling potential of opening windows, and 3) the use of an “adaptive algorithm” for predicting window opening behaviour for thermal simulation in ESP-r. We found that the mean indoor and outdoor temperatures when the window was open were higher than when it was closed, but show that nonetheless there was a useful cooling effect from opening a window. The adaptive algorithm for window opening behaviour was then used in thermal simulation studies for some typical office designs. The thermal simulation results were in general agreement with the findings of the field surveys

A window opening algorithm and UK office temperature field results and thermal simulation

This investigation of the window opening data from extensive field surveys in UK office buildings investigates 1) how people control the indoor environment by opening windows, 2) the cooling potential of opening windows, and 3) the use of an “adaptive algorithm” for predicting window opening behaviour for thermal simulation in ESP-r. We found that the mean indoor and outdoor temperatures when the window was open were higher than when it was closed, but show that nonetheless there was a useful cooling effect from opening a window. The adaptive algorithm for window opening behaviour was then used in thermal simulation studies for some typical office designs. The thermal simulation results were in general agreement with the findings of the field surveys

The Infrared Surface Brightness Fluctuation Distances to the Hydra and Coma Clusters

We present IR surface brightness fluctuation (SBF) distance measurements to NGC 4889 in the Coma cluster and to NGC 3309 and NGC 3311 in the Hydra cluster. We explicitly corrected for the contributions to the fluctuations from globular clusters, background galaxies, and residual background variance. We measured a distance of 85 +/- 10 Mpc to NGC 4889 and a distance of 46 +/- 5 Mpc to the Hydra cluster. Adopting recession velocities of 7186 +/- 428 km/s for Coma and 4054 +/- 296 km/s for Hydra gives a mean Hubble constant of H_0 = 87 +/- 11 km/s/Mpc. Corrections for residual variances were a significant fraction of the SBF signal measured, and, if underestimated, would bias our measurement towards smaller distances and larger values of H_0. Both NICMOS on the Hubble Space Telescope and large-aperture ground-based telescopes with new IR detectors will make accurate SBF distance measurements possible to 100 Mpc and beyond.Comment: 24 pages, 4 PostScript figures, 2 JPEG images; accepted for publication in Ap

Thermal Stability of the Human Immunodeficiency Virus Type 1 (HIV-1) Receptors, CD4 and CXCR4, Reconstituted in Proteoliposomes

Background: The entry of human immunodeficiency virus (HIV-1) into host cells involves the interaction of the viral exterior envelope glycoprotein, gp120, and receptors on the target cell. The HIV-1 receptors are CD4 and one of two chemokine receptors, CCR5 or CXCR4. Methodology/Principal Findings: We created proteoliposomes that contain CD4, the primary HIV-1 receptor, and one of the coreceptors, CXCR4. Antibodies against CD4 and CXCR4 specifically bound the proteoliposomes. CXCL12, the natural ligand for CXCR4, and the small-molecule CXCR4 antagonist, AMD3100, bound the proteoliposomes with affinities close to those associated with the binding of these molecules to cells expressing CXCR4 and CD4. The HIV-1 gp120 exterior envelope glycoprotein bound tightly to proteoliposomes expressing only CD4 and, in the presence of soluble CD4, bound weakly to proteoliposomes expressing only CXCR4. The thermal stability of CD4 and CXCR4 inserted into liposomes was examined. Thermal denaturation of CXCR4 followed second-order kinetics, with an activation energy (E$_a$) of 269 kJ/mol (64.3 kcal/mol) and an inactivation temperature (T$_i$) of 56°C. Thermal inactivation of CD4 exhibited a reaction order of 1.3, an E$_a$ of 278 kJ/mol (66.5 kcal/mol), and a T$_i$ of 52.2°C. The second-order denaturation kinetics of CXCR4 is unusual among G protein-coupled receptors, and may result from dimeric interactions between CXCR4 molecules. Conclusions/Significance: Our studies with proteoliposomes containing the native HIV-1 receptors allowed an examination of the binding of biologically important ligands and revealed the higher-order denaturation kinetics of these receptors. CD4/CXCR4-proteoliposomes may be useful for the study of virus-target cell interactions and for the identification of inhibitors

Factors That Impact Student Performance in a Course Sequence

On-line courses have become an important component of the delivery of courses in all areas of education. The validity of online delivery is challenged if Web students perform poorly in subsequent major courses. This paper investigates the effect of mode of delivery and other factors on the level of success, failure, potential, and limitations of web delivery in course sequences. This study was conducted on a two-course sequence in the Computer Information Systems Department at Metropolitan State College of Denver. The result of this research identifies important factors impacting student success in this two course sequence

Measuring Distances Using Infrared Surface Brightness Fluctuations

Surface brightness fluctuations (SBFs) are much brighter in the IR than they are at optical wavelengths, making it possible to measure greater distances using IR SBFs. We report new K' (2.1 micron) SBF measurements of 9 galaxies in the Fornax and Eridanus clusters using a 1024^2-pixel HgCdTe array. We used improved analysis techniques to remove contributions from globular clusters and background galaxies, and we assess the relative importance of other sources of residual variance. We applied the improved methodology to Fornax and Eridanus images and to previously published Virgo cluster data. Apparent fluctuation magnitudes were used in conjunction with Cepheid distances to M31 and the Virgo cluster to calibrate the K' SBF distance scale. We find the absolute fluctuation magnitude MK'= -5.61+/-0.12, with an intrinsic scatter to the calibration of 0.06 mag. No statistically significant change in MK' is detected as a function of (V-I). Our calibration is consistent with constant age and metallicity stellar population models. The lack of a correlation with (V-I) in the context of the stellar population models implies that elliptical galaxies bluer than (V-I)=1.2 have SBFs dominated by younger (5-8 Gyr) populations. K' SBFs prove to be a reliable distance indicator as long as the residual variance from globular clusters and background galaxies is properly removed. Also, it is important that a sufficiently high S/N ratio be achieved to allow reliable sky subtraction because residual spatial variance can bias the measurement of the SBF power spectrum. (abridged)Comment: Accepted for publication in ApJ, 44 pages, 10 Postscript figure

An Exploration Of The Impact Of Online Delivery In Prerequisite Courses On CIS Majors Course Sequence

On-line courses have become an important component of the delivery of courses in all areas of education. The validity of online delivery is challenged if Web students perform poorly in subsequent major courses. This paper investigates the level of success, failure, potential, and limitation of on-line delivery in the CIS area at MSCD. The result of this research will provide a framework for developing a methodology for this kind of study, allowing academic institutions to evaluate the success and utility of online courses