Determination of nitric oxide (NO) in serum (a), percentage of blood methemoglobin (b) levels of malondialdehyde (MDA) in plasma (c) of patients with untreated leprosy (MDT 0) and after the third dose supervised treatment (MDT 3).

<p>Figures in the chart are expressed as mean ± SD. *p<0.05 compared to MDT0 (ANOVA).</p

Representation of the CYP 2C19.

<p>Area covered (depicted as <i>light blue</i> transparent <i>solid surface</i>) by the two internal cavities (catalytic site cavity and adjacent cavity) of human microsomal cytochrome P450 (CYP) 2C19 (<i>brown</i>). The heme prosthetic group is represented in <i>green</i> and the molecule of dapsone in the color <i>red</i> (<b>a</b>). Delimitation of the area occupied by the two internal cavities (catalytic site cavity and adjacent cavity) of the CYP2C19 (<b>b</b>).</p