自称表現に見られる日中両言語の人称代名詞と親族語彙

千葉大学社会文化科学研究科研究プロジェクト報告書第84集『日中両言語における代名詞及び親族語彙の対照研究-琉球方言との比較研究も含めて』所

¹³C NMR spectrum of A21 analogue.

<p>¹³C NMR spectrum of A21 analogue.</p

Pharmacological tests of compounds of Table 1.

<p>Pharmacological tests of compounds of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0162171#pone.0162171.t001" target="_blank">Table 1</a>.</p

Histopathological analysis of intestinal epithelium obtained five weeks after <i>Candida albicans</i> inoculation in mice.

<p>(A) Intestinal epithelium of Balb-C mouse with normal appearance. (B) Intestinal epithelium showing severe damage with necrotic enteritis. We can observe the loss of microvilli (■), presence of inflammatory cells (ic) and cellular lysis (*) is observed. (C) Intestinal epithelium from a representative mouse with candidiasis treated with a daily IP dose of 4 mg/kg AmB (DMSO) during the last two of the five weeks. Loss of microvilli (■), presence of inflammatory cells (ic), and cellular lysis (*) is observed. (D) Intestinal epithelium from a representative mouse with candidiasis treated with a daily IP dose of 4 mg/kg AmB (Abelcet^®) during the last two of the five weeks. The kidney appears normal and has abundant caliciform cells. (E) Intestinal epithelium from a representative mouse with candidiasis treated with a daily IP dose of 4 mg/kg <b>A21</b> during the last two of the five weeks. Epithelium with normal appearance. (F) Intestinal epithelium from a representative mouse with candidiasis treated with a daily IP dose of 12 mg/kg <b>A21</b> during the last two of the five weeks. Epithelium with normal appearance.</p

Force field definition for AmB and A21 atoms.

<p>Values for atom type, atom name, partial charge, and mass are shown. In the case of <b>A21</b>, charges of the R chemical group were taken from the ARGN [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0162171#pone.0162171.ref044" target="_blank">44</a>] or HISA [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0162171#pone.0162171.ref057" target="_blank">57</a>] 53A6 GROMOS residues. Atom name labels are mapped to the corresponding structure, shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0162171#pone.0162171.g006" target="_blank">Fig 6</a>.</p

Histopathological evaluation of infected mice treated with AmB or A21.

<p>Histopathological evaluation of infected mice treated with AmB or A21.</p

Synthesis of Amphotericin B amide analogues A1–A7.

<p>Reagents and conditions: (a) Selected amine, DPPA, Et₃N, DMAC, rt.</p

Example of single channel along 1 s activity of A21 in a POPC membrane containing 30% Mol ergosterol or 30% Mol cholesterol, 25°C, 100 mV and concentrations of 10 and 200 μMol, respectively.

<p>A larger channel for the ergosterol-containing membrane is presented (note the different scale) since, in this case, it is very common. These records were treated as described in the Methods section.</p

Comparative action of Amphotericin B and derivative A21 on <i>Candida albicans</i> ATCC 10231 (A), <i>Candida albicans</i> ATCC 752 (B) and <i>Candida krusei</i> ATCC 6258 (C).

<p>Cells were incubated for 24 h at 37 C under aerobic conditions, stained with propidium iodide (PI). Antifungal activity was determined by flow cytometry. The results are presented as means ± SD of 3 independent experiments. *p < 0.05 is the comparison with control value. #p< 0.05 the comparison with AmB.</p

Example of single channel along 1 s activity of Amphotericin B in a POPC membrane containing 30% Mol ergosterol or 30% Mol cholesterol, 25°C, 100 mV and concentrations of 5 and 15 μMol respectively.

<p>These records were treated as described in the Methods section.</p