A tabular editor for user interfaces modelling

The IVY workbench is a model-based tool for the automated analysis of interactive systems. Models are written in a domain specific language, MAL interactors, using a textual editor. This language has shown to be the main barrier for tool adoption by inexperienced users. We propose a new editor, which eases modelling, in order to lower the tool’s learning curve.Trabalho realizado no ambito do projecto “NORTE-01- ˆ 0145-FEDER-000016” financiado pelo Programa Operacional Regional do Norte (NORTE 2020), PORTUGAL 2020 e Uniao˜ Europeia, atraves do Fundo Europeu para o Desenvolvimento ´ Regional (FEDER).info:eu-repo/semantics/publishedVersio

MODUS: model-based user interfaces prototyping

Model-based methodologies, supported by automatic generation, have been proposed as a solution to reduce software development costs. In the case of interactive computing systems specific challenges arise. On the one hand, a high level of automation requires the use of detailed models, which is contrary to the iterative development process, based on the progressive refinement of user interface mockups, typical of user centered development processes. On the other hand, layered software architectures imply a distinction between the models used in the business logic and in the user interface, raising consistency problems between the models at each level. This article proposes a tool supported approach to user interface generation directly from the architectural models of the business logic. In many situations, user interfaces provide similar features inside a specific domain. The identification of the application domain is thus a key factor in supporting the automation of the generation process.This work was financed by the ERDF – European Regional Development Fund through the Operational Programme for Competitiveness and Internationalisation - COMPETE 2020 Programme, and by National Funds through the FCT – Fundação para a Ciência e a Tecnologia (Portuguese Foundation for Science and Technology) within project POCI-01-0145- FEDER-006961.info:eu-repo/semantics/publishedVersio

Carcinogenic Ability of Schistosoma Haematobium Possibly through Oncogenic Mutation of KRAS Gene

Schistosoma haematobium is a parasitic flatworm that infects millions of people, mostly in the developing world, and is associated with high incidence of bladder cancer, although why is not clear. Previously, we have used CD-1 mice to show that Schistosoma haematobium total antigen (Sh) has a carcinogenic ability. Sh intravesically instillation induced the development of several urothelial lesions, namely nodular hyperplasia and dysplasia (LGIUN—Low Grade Intra-Urothelial Neoplasia) after 40 weeks of treatment. These results suggested that Sh induce urothelium malignization. Bladder carcinoma frequently harbours gene mutations that constitutively activate the receptor tyrosine kinase-Ras pathway for this reason we studied activating mutations in KRAS gene. Twenty percent of the bladders with dysplasia presented a KRAS mutation in codon 12 of exon 2. We concluded from these results that the parasite extract of S. haematobium has carcinogenic ability possibly through oncogenic mutation of KRAS gene