Demographic information for the healthy controls, siblings and patients.

a<p>Groups were compared with an analysis of variance (ANOVA) and did not differ significantly (p = 0.62).</p>b<p>Level of education was defined according to scoring system of Verhage <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0099667#pone.0099667-Verhage1" target="_blank">[57]</a> (ordinal scale). Group differences for gender and education were tested with a chi-square and kruskal-wallis test, respectively. Neither gender (p = 0.23) nor level of education (p = 0.72) differed between groups.</p

fMRI results for the contrast Attend negative>Suppress.

<p>L, Left; R, Right; MNI, Montreal Neurological Institute.</p

Experimental design for a single trial.

<p>The task consisted of 110 trials (22 neutral and 88 negative). A single trial lasted 15,5 seconds. Every 9 or 10 trials were followed by a fixation cross of 20 seconds.</p

fMRI results for the contrast Reappraise >Attend negative.

<p>L, Left; R, Right; MNI, Montreal Neurological Institute; ACC, anterior cingulate cortex; DLPFC, dorsolateral prefrontal cortex; DMPFC, dorsomedial prefrontal cortex; VLPFC, ventrolateral prefrontal cortex.</p

Mean scores on questionnaires and on the emotion regulation task for healthy controls, siblings and patients.

a<p>For one subject, no behavioral data for the emotion regulation task were available due to technical problems.</p

Activation for HC only during reappraisal.

<p>Activation for HC only during reappraisal.</p

Affective ratings for the emotion regulation task per condition.

<p>Lines represent the three groups separately.</p

Group comparisons during reappraisal.

<p>A) HC versus schizophrenia patients. B) HC versus non affected siblings. C) Non-affected siblings versus schizophrenia patients.</p

Post-hoc results (mean difference and <i>p</i>-value) of group differences on the cognitive alexithymia subscales.

<p>Post-hoc results (mean difference and <i>p</i>-value) of group differences on the cognitive alexithymia subscales.</p

Means and standard deviations of demographic variables and alexithymia scores per group and test statistics of group differences.

<p>Means and standard deviations of demographic variables and alexithymia scores per group and test statistics of group differences.</p