9 research outputs found
Meta-analysis association results for hemoglobin in unconditional and conditional analyses in the <i>ABO</i> locus.
<p>Regional plots show (A) unconditional analysis and analysis conditional on (B) O, (C) AO, (D) AA, (E) B and (F) AB blood group haplotype. The most significant SNP in the unconditional analysis, rs507666, is highlighted throughout to facilitate comparison of results. The color coding of the LD between the SNPs ranges from dark blue for r<sup>2</sup> = 0–0.2 to red for r<sup>2</sup> = 0.8–1, and is grey where LD information was not available. Blue line represents suggestive and red line significant threshold.</p
Manhattan plots of meta-analysis association results in unconditional and conditional analyses for hemoglobin (Hb), hematocrit (Hct) and red blood cell count (RCC).
<p>Results show unconditional analysis for all three traits (top row) and analysis of Hb conditional on (A) Hct and (B) RCC, of Hct conditional on (C) Hb and (D) RCC and of RCC conditional on (E) Hb and (F) Hct. Line at–log<sub>10</sub>(<i>P</i> value) = 5.3 represents suggestive threshold and line at–log<sub>10</sub>(<i>P</i> value) = 7.3 significant threshold.</p
One-way analysis of variance in hemoglobin (Hb), hematocrit (Hct) and red blood cell count (RCC) between different blood groups, as derived based on three SNP haplotypes.
<p>One-way analysis of variance in hemoglobin (Hb), hematocrit (Hct) and red blood cell count (RCC) between different blood groups, as derived based on three SNP haplotypes.</p
Comparison of the effect sizes on 15 <i>ABO</i> SNPs between eight different traits.
<p>Traits include von Willebrand factor (log transformed, logVWF) and factor VIII (FVIII) for coagulation factors, total cholesterol (TC) and low-density lipoprotein (LDL) for lipids, hemoglobin (Hb), red blood cell count (RCC) and hematocrit (Hct) for the red blood cell (RBC) traits and alkaline phosphatase (log transformed, logALP) for liver marker group. The colored bar for each SNP represents the 95% confidence interval of the effect size.</p
Results of meta-analysis and replication analysis for 15 most significant SNPs in the <i>ABO</i> locus.
<p>Results of meta-analysis and replication analysis for 15 most significant SNPs in the <i>ABO</i> locus.</p
Blood groups derived based on three SNP haplotypes.
<p>Blood groups derived based on three SNP haplotypes.</p
Information on genotyped and imputed SNPs.
*<p>The WHII study was typed at two centres with different array readers, which were compared and shown to be concordant.</p
Disease event definitions, incident and prevalent events by disease and medication use in the UCLEB consortium.
<p>Total incident CHD =  incident non-fatal MI or revascularization plus fatal CHD (ICD codes I20–I25, I516).</p><p>Total prevalent CHD  =  prevalent non-fatal MI or revascularization.</p><p>Total incident stroke  =  incident non-fatal stroke (ischaemic & haemorrhagic combined, but excluding TIA) plus fatal stroke (ICD codes I60×, I61×, I62, I629 I63×, I64× I65× I66×, I67, I672, I678, I679, I69×, G46×, G450, G451, G452, G453).</p><p>Total diabetes defined by a combination of self-report, medical history review, use of glucose lowering medication, or fasting glucose >7 mmol/L.</p>*<p>1958BC are currently undertaking case ascertainment.</p