Prevalence of podoconiosis by country.

<p>Prevalence of podoconiosis by country.</p

Podoconiosis prevalence by age group in selected studies Ethiopia 1 [4], Ethiopia 2 [29], Cameroon 1 [49] and Cameroon 2 [50].

<p>Podoconiosis prevalence by age group in selected studies Ethiopia 1 [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0006324#pntd.0006324.ref004" target="_blank">4</a>], Ethiopia 2 [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0006324#pntd.0006324.ref029" target="_blank">29</a>], Cameroon 1 [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0006324#pntd.0006324.ref049" target="_blank">49</a>] and Cameroon 2 [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0006324#pntd.0006324.ref050" target="_blank">50</a>].</p

Countries reporting existence of podoconiosis.

<p>Countries reporting existence of podoconiosis.</p

Geographical distribution of A) Surveys included B) Prevalence of podoconiosis. Dots represent various island nations.

<p>Geographical distribution of A) Surveys included B) Prevalence of podoconiosis. Dots represent various island nations.</p

Podoconiosis prevalence studies included in the review.

<p>Podoconiosis prevalence studies included in the review.</p

The prevalence of <i>P</i>. <i>falciparum</i> and hookworm co-endemicity, and significant hotspots of <i>P</i>.<i>falciparum</i> and hookworm co-endemicity in sub-Saharan Africa.

’The density description next to the colour coded box refers to the prevalence of P. falciparum, whilst the column further to the right refers to density of hookworm. Link to the base layer of the map: https://gadm.org/index.html.</p

The prevalence of P. falciparum and soil-transmitted helminth (Hookworm, <i>Ascaris lumbricoides</i>, <i>Trichiuris trichiura</i>) co-endemicity, and their corresponding significant hotspots locations (ADM1, ADM2, and ADM3) in sub-Saharan Africa, pre-2003 and 2003–2018.

(DOCX)</p

Alignment of Tf binding sites (ESAG6/7) and polymorphic ESAG3 regions.

<p>Amino acid alignment of polymorphic regions of ESAG6/7 (A) and ESAG3 (B). Tf binding sites are highlighted with red squares. Other polymorphic regions of ESAG6/7 are marked with black boxes. Polymorphic regions of ESAG3 are shown. I: S103-E119; II: L171-K189; III: A/G215-D/E244; IV: A309-R/E321. <i>T</i>. <i>b. brucei</i> ESAGs 6, 7 and 3 are shown in red.</p

Summary table of STH prevalence estimates by country and frequency of prevalence surveys per country, sub-Saharan Africa, 2000–2018.

(DOCX)</p

Moran’s I statistic plot showing spatial auto-correlation for <i>P</i>. <i>falciparum</i> vs any soil-transmitted helminth co-endemicity in sub-Saharan Africa, pre-2003 and 2003–2018.

(TIF)</p