<i>AnomalyExplorer</i> program.

<p>A) Overview of the software. B) Each bar presents a single Ca²⁺ signal of a single cell and shows the distribution of abnormality patterns in the recording. The total number of anomalies in all of the files can be observed on the right. C) Dynamic controllers for the anomaly detection. D) The detailed view of one Ca²⁺ signal plot showing color-coded anomalies detected with the help of three yellow regression lines (top, bottom and middle) and the sections subsequently rising and decaying separated with small grey vertical lines above the signal showing how the Ca²⁺ transients ascend (light bars) and descend (dark bars).</p

Detected Ca²⁺ signal abnormality patterns from <i>AnomalyExplorer</i> analysis.

<p>Examples of the color-coded abnormality subgroups that <i>AnomalyExplorer</i> detects as well as normal Ca²⁺ signals as follows: low peaks, double peaks, middle peaks, oscillation, irregular phase, plateau abnormality, and a signal with multiple different abnormalities. Abnormalities are detected with the help of three yellow regression lines and subsequently rising and decaying sections separated with small grey vertical lines above the signal showing how the Ca²⁺ transient ascends and descends monotonously. The same abnormality patterns were detected in a manual analysis made with visual recognition.</p

Detailed results in the <i>AnomalyExplorer</i> overview.

<p>View of the <i>AnomalyExplorer</i> analyzed Ca²⁺ signals summarizing the results recorded with A) Recording Software 1 and B) Recording Software 2. It shows the detailed number of subgroup specific abnormalities in each Ca²⁺ signal in one bar and the total number and percentages of all abnormality subgroups. Each bar represents a single cell (signal) and only signals presenting with abnormalities are shown. Altogether, 132 Ca²⁺ signals were recorded with Recording Software 1, 47 which (36%) presented abnormalities. The corresponding number from 212 Ca²⁺ signals recorded with Recording Software 2 was 88 (42%).</p