Deliverable report on 2.2d - Protocols for measuring spontaneous activity in peripheral afferent C-fibres in various models of neuropathic pain in rats

<p>Deliverable report on 2.2d - </p> <p><strong>Protocols for measuring spontaneous activity in peripheral afferent C-fibres in various models of Neuropathic Pain in rats.  Published by Workpackage 2 of the Europain project.</strong></p> <p><br>The EuroPain project has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement n° 115007, resources for which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/20072013) and EFPIA companies’ in kind contribution.This is a unique public-private partnership designed by the European Commission and European Federation of Pharmaceutical Industries and Associations (EFPIA). It is a pan-European collaboration that brings together large biopharmaceutical companies, small- and medium-sized enterprises (SMEs), patient organisations, academia, hospitals and public authorities.</p

Oxidant-Free Au(I)-Catalyzed Halide Exchange and C_sp2–O Bond Forming Reactions

Au has been demonstrated to mediate a number of organic transformations through the utilization of its π Lewis acid character, Au­(I)/Au­(III) redox properties or a combination of both. As a result of the high oxidation potential of the Au­(I)/Au­(III) couple, redox catalysis involving Au typically requires the use of a strong external oxidant. This study demonstrates unusual external oxidant-free Au­(I)-catalyzed halide exchange (including fluorination) and C_sp2–O bond formation reactions utilizing a model aryl halide macrocyclic substrate. Additionally, the halide exchange and C_sp2–O coupling reactivity could also be extrapolated to substrates bearing a single chelating group, providing further insight into the reaction mechanism. This work provides the first examples of external oxidant-free Au­(I)-catalyzed carbon–heteroatom cross-coupling reactions