ROC scatter plot and ROC curve for all included studies (n = 28) and summary estimate for the subset of studies with cut-off point of 16 (n = 22).

<p>* Estimated with Rutter and Gatsonis hierarchical model; # Estimated with bivariate model.</p

Coupled Forest plot of sensitivities and specificities of included studies (n = 28).

<p>Coupled Forest plot of sensitivities and specificities of included studies (n = 28).</p

Description of eligible studies for the assessment of diagnostic accuracy of the CES-D (n = 28).

<p>Description of eligible studies for the assessment of diagnostic accuracy of the CES-D (n = 28).</p

HRQL loss according to sociodemographic and clinical variables, stratified by sex.

1<p>Prior to the flu episode in adults of working age (16 to 64 years old); ²in women of childbearing age (15 to 50 years old.)</p>†<p>Statistically significant differences when comparing the change in EQ-5D in females and males (p <0.05).</p>*<p>Statistically significant differences when comparing the EQ-5D change among specific characteristics in each group or sex group (p <0.05).</p><p>A U-Mann Whitney test or Kruskal Wallis test were performed to compare means HRQL losses.</p

Forest plot of <i>5-HTTLPR</i> biallelic recessive model (<i>SS</i> vs <i>L</i>+) and Post-traumatic Stress Disorder (PTSD).

<p>Forest plot of <i>5-HTTLPR</i> biallelic recessive model (<i>SS</i> vs <i>L</i>+) and Post-traumatic Stress Disorder (PTSD).</p

Analyses of publication bias by the Egger test.

<p>SE: Standard error; T: T-test; df: Degrees of freedom. BFM: Biallelic Frequency Model; BDM: Biallelic Dominant Model; BRM: Biallelic Recessive Model; TFM: Triallelic Frequency Model; TDM: Triallelic Dominant Model; TRM: Triallelic Recessive Model.</p

Frequencies of the <i>5-HTTLPR</i> alleles and polymorphisms of the included studies^&.

<p><i>S</i>, short allele; <i>L</i>, long allele; <i>S</i>' as <i>S</i> + <i>L_G</i>; and <i>L</i>' as <i>L_A.</i></p>&<p>Dominant model (<i>S+</i> vs <i>LL</i> or <i>S</i>'+vs L'L'): <i>S+</i> (or <i>S</i>'<i>+</i>) genotype frequencies are calculated as the sum of <i>SS</i> (or <i>S</i>'<i>S</i>') and <i>SL</i> (or <i>S</i>'<i>L</i>') frequencies. Recessive model (<i>SS</i> vs <i>L+</i> or <i>S</i>'<i>S</i>' vs <i>L</i>'<i>+</i>): <i>L+</i> (or <i>L</i>'+) genotype frequencies are calculated by the sum of <i>LL</i> (or <i>L</i>'<i>L</i>') and <i>SL</i> (or <i>SvL</i>') genotype frequencies.</p

Forest plot of <i>5-HTTLPR</i> triallelic dominant model (<i>S</i>'+ vs <i>L</i>'<i>L</i>') and Post-traumatic Stress Disorder (PTSD).

<p>Forest plot of <i>5-HTTLPR</i> triallelic dominant model (<i>S</i>'+ vs <i>L</i>'<i>L</i>') and Post-traumatic Stress Disorder (PTSD).</p

Description of the quality characteristics of the included and excluded studies in the Meta-Analysis of <i>5-HTTLPR</i> polymorphisms and Post-traumatic Stress Disorder (PTSD).

$<p>Representativeness of cases included all eligible cases with outcome of interest over a defined period of time, all cases in a defined catchment area, all cases in a defined hospital or clinic, group of hospitals, health maintenance organization, or an appropriate sample of those cases (e.g. random sample).</p>#<p>Representativeness of controls assesses whether the control series used in the study is derived from the same population as the cases and essentially would have been cases had the outcome been present and included community and clinical controls within the same community or hospitalized population as cases.</p>&<p>If Yes, the % of the different ethnics groups are provided in brackets.AS: Asiatic. EA: Euro-American; AA: Afro-Americans; Af: African; Eu: Europeans.</p>†<p>HWE: Hardy-Weinberg Equilibrium; ‡TQS: Total Quality Score.</p

Funnel plots of <i>5-HTTLPR</i> polymorphisms and Post-traumatic Stress Disorder (PTSD) to assess publication bias.

<p><b>White circles</b> represent each of the included studies. <b>Black circles</b> represent the new effect estimated to achieve symmetry.</p