Orbital similarity functions - application to asteroid pairs

The paper expands the idea of Vokrouhlický and Nesvorný who used a modified Zappalà et al. metric with osculating elements in search for pairs of asteroids suspected of having a common origin. Using six different orbital similarity functions, we find that five of them display a similar excess of close pairs in the catalogue of osculating elements. The excess is even higher when mean orbital elements are used. Similarly, when the mean elements are applied, there is a better agreement between the closest pairs found in the same catalogue using different metrics. The common subset of 62 pairs from five lists of 100 closest pairs according to different distance functions is provided. Investigating an artificial sample of asteroid orbital pairs with a known initial orbital velocity difference we find that the Drummond metric best preserves orbital proximity over long time intervals

Experimental Meningococcal Sepsis in Congenic Transgenic Mice Expressing Human Transferrin

Severe meningococcal sepsis is still of high morbidity and mortality. Its management may be improved by an experimental model allowing better understanding of its pathophysiology. We developed an animal model of meningococcal sepsis in transgenic BALB/c mice expressing human transferrin. We studied experimental meningococcal sepsis in congenic transgenic BALB/c mice expressing human transferrin by transcriptional profiling using microarray analysis of blood and brain samples. Genes encoding acute phase proteins, chemokines and cytokines constituted the largest strongly regulated groups. Dynamic bioluminescence imaging further showed high blood bacterial loads that were further enhanced after a primary viral infection by influenza A virus. Moreover, IL-1 receptor–associated kinase–3 (IRAK-3) was induced in infected mice. IRAK-3 is a negative regulator of Toll-dependant signaling and its induction may impair innate immunity and hence result in an immunocompromised state allowing bacterial survival and systemic spread during sepsis. This new approach should enable detailed analysis of the pathophysiology of meningococcal sepsis and its relationships with flu infection

Creating a LOC based portable health-care platform using a universal mobile NFC host environment

This paper presents our recent plan to provide support for a portable diagnostic health care platform (namely POCEMON) based on Lab-On-Chip (LOC) concept. The idea is based on our achievements on creating a host environment that combines mobile phones/PDAs with the Near Field Communication (NFC) wireless technology to further support mobile diagnostic health care applications. NFC enabled mobile phone based host environment works as a reference platform regardless of the phone type and the nature of the services required. In connection to this, we will describe further insights on how this cutting edge technology may be leveraged in the health care sector providing efficient point-of-care monitoring and diagnosis