Functional surface micropatterns by dewetting of thin polymer films

Patterned polymer surfaces are of great importance with respect to an increasing number of technological and bio-medical applications, due to their great versatility in terms of chemical composition, properties and processing techniques. Surface micro-patterning by spontaneous dewetting of thin polymer films represents a versatile and robust process to fabricate surfaces with controlled topography and chemistry at the micro-scale. In this Thesis, we used polymer dewetting in combination with complementary approaches to engineer both surface chemistry and the ordering of the dewetting patterns. The dewetting of poly(D,L-glycolide-co-lactide) (PLGA) thin films on polystyrene (PS) was combined with the grafting of protein-repellent poly(ethylene glycol) (PEG), in order to form topographical and chemical surface micropatterns consisting in protein-adhesive PS domains surrounded by protein-repellent PEG-grafted PLGA films. The produced micropatterned surfaces were used for site-specific protein adsorption, and represent a promising platform for biological applications, such as proteomics, single-cell studies and tissue engineering. Spatially ordered surface micropatterns were obtained by combining polymer dewetting with microcontact printing and colloidal lithography, respectively. The dewetting of thin PS films was guided within specific regions of the substrate by prestamping of the silicon substrate with self-assembled monolayers of an alkylsilane by microcontact printing. Ordered micropatterns consisting in arrays of holes with tunable size were obtained by exploiting the spontaneous dewetting of poly(4-vinyl pyridine) (P4VP) thin films on PS from the holes produced by colloidal imprinting with two-dimensional colloidal crystals assembled on the polymer bilayer

Integration Between Bus and Light Rapid Transit on Midland Metro Line 1

It had been intended, when the proposed paper was submitted, to report on the first attempts at bus/LRT interchange on the new Midland Metro, and on the response of private sector bus operators who could, should the interchange not be perceived as meeting users’ needs, take over the provision of through bus services parallel to the new line. Delays in the opening of this new metro meant that evidence was not available at the time of writing, but even so there is other less direct evidence that can shed light on the general issue of integration in a de-regulated environment. The focus of the paper is upon how the users’ wishes for a seamless journey can best be reconciled with the requirements of the concessionaire and other operators working in an environment where some degree of competition takes place.Institute of Transport and Logistics Studies. Faculty of Economics and Business. The University of Sydne

Girls don't rock and boys don't bop: adolescent musical identity and gender stereotypes in popular music.

This study investigated what are considered to be gender appropriate musical behaviours from the perspective of adolescents, with a particular focus on listening behaviours and musical preferences. Gender stereotypes in popularised music and ways in which stereotypes are generated through popular media is also explored. Educational implications of gender delineated musical meaning in popular styles of music are considered in order to contribute to a growing body of research on the use of popular music in the classroom. Data were collected from three focus groups involving adolescents of varied ages from three different schools. Music educators from two of the participating schools also contributed to the study. Grounded theory was developed using open and axial coding of the collected data. Results indicated that gender stereotypes in music listened to by adolescents affect musical identity formation to varying degrees depending on susceptibility to social pressures. Gender delineated musical meaning in the classroom was found to have an impact on musical behaviours of students as a result of teacher attitudes and initiatives towards creating a gender balanced music classroom

Diagnostic yield and accuracy of CT angiography, MR angiography, and digital subtraction angiography for detection of macrovascular causes of intracerebral haemorrhage: Prospective, multicentre cohort study

Study question What are the diagnostic yield and accuracy of early computed tomography (CT) angiography followed by magnetic resonance imaging/angiography (MRI/MRA) and digital subtraction angiography (DSA) in patients with non-traumatic intracerebral haemorrhage? Methods This prospective diagnostic study enrolled 298 adults (18-70 years) treated in 22 hospitals in the Netherlands over six years. CT angiography was performed within seven days of haemorrhage. If the result was negative, MRI/MRA was performed four to eight weeks later. DSA was performed when the CT angiography or MRI/MRA results were inconclusive or negative. The main outcome was a macrovascular cause, including arteriovenous malformation, aneurysm, dural arteriovenous fistula, and cavernoma. Three blinded neuroradiologists independently evaluated the images for macrovascular causes of haemorrhage. The reference standard was the best available evidence from all findings during one year's follow-up. Study answer and limitations A macrovascular cause was identified in 69 patients (23%). 291 patients (98%) underwent CT angiography; 214 with a negative result underwent additional MRI/MRA and 97 with a negative result for both CT angiography and MRI/MRA underwent DSA. Early CT angiography detected 51 macrovascular causes (yield 17%, 95% confidence interval 13% to 22%). CT angiography with MRI/MRA identified two additional macrovascular causes (18%, 14% to 23%) and these modalities combined with DSA another 15 (23%, 18% to 28%). This last extensive strategy failed to detect a cavernoma, which was identified on MRI during follow-up (reference strategy). The positive predictive value of CT angiography was 72% (60% to 82%), of additional MRI/MRA was 35% (14% to 62%), and of additional DSA was 100% (75% to 100%). None of the patients experienced complications with CT angiography or MRI/MRA; 0.6% of patients who underwent DSA experienced p

Aspects of imaging benign and malignant rectal and perirectal diseases: preoperative staging of rectal carcinoma, detection of recurrent rectal carcinoma, benign (peri)rectal diseases

Contains fulltext : mmubn000001_211286230.pdf (publisher's version ) (Open Access)Promotores : G. Rosenbusch en J. Jansen158 p

Schedeldakreconstructies bij kinderen

Contains fulltext : 22953.PDF (publisher's version ) (Open Access

Variatie in radiologische bevindingen bij mandibulofaciale dysostosis

Contains fulltext : 23322___.PDF (publisher's version ) (Open Access

Magnetic resonance angiography has a high reliability in the detection of renal artery stenosis

Contains fulltext : 24347___.PDF (publisher's version ) (Open Access

CT en MRI in de selectieprocedure voor cochleaire implantatie

Contains fulltext : 25394___.PDF (publisher's version ) (Open Access

Radiologische en klinische aspecten van functionele endonasale chirurgie.

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