Identification of residual stress directionality using anisotropic indenter in instrumented indentation testing

Instrumented indentation testing can be used to quantitatively evaluate the local residual stress on the surface. Many studies have confirmed that indentation load-displacement curves obtained from Vickers indentation and Berkovich indentation are shifted depending on the residual stress state. Based on this, many researchers have proposed models for evaluating the residual stress by comparing indentation curves obtained from stressed and stress-free specimens of the same composition and microstructure. Though Vickers and Berkovich indenters can quantitatively evaluate the residual stresses, it is difficult to evaluate their directionality such as principal direction and principal stresses because the indenters are axisymmetric. In order to overcome these limitations, we have evaluated the residual stress directionality by using less axisymmetric indenters, such as the Knoop indenter and a modified Berkovich indenter (a conventional Berkovich indenter extended along one axis). [1] With these two sorts of indenters, the degree of shifting of the indentation curve depends on the direction of the long axis of the indenter in the non-equibiaxial stress state. We introduced a conversion factor, a proportional constant between indentation load difference and stress, and proposed a method for quantitatively evaluating the directionality of surface residual stress using this conversion factor. We applied a non-equibiaxial stress state to cruciform specimens and verified the accuracy of the proposed model using the conversion factor in Knoop and modified Berkovich indentation testing. Also, the experiments and finite-element analysis of Knoop and modified Berkovich indentations showed that the ratio of the length of the major axis and minor axis of the indenter is correlated to the conversion factor ratio; a generalized formula is proposed. REFERENCES [1] Jong-hyoungKim and Huiwen Xu, “Determination of directionality of non-equibiaxial residual stress by nanoindentation testing using a modified Berkovich indenter”, JMR 33. 3849-3856, 2018

Back Extensor Strengthening Exercise and Backpack Wearing Treatment for Camptocormia in Parkinson's Disease: A Retrospective Pilot Study

Objective To investigate the effect of a conservative treatment regime in Parkinson's disease patients with camptocormia. Methods Nine patients with Parkinson's disease were included in a retrospective pilot study of the value of back extensor strengthening exercise. Six inpatients received a 30-minute treatment, twice daily for 5 weeks, being treated on average for 34 days; while three outpatients visited the clinic and were educated for home exercise and backpack wearing treatment. Outpatients should be scheduled to visit the outpatient department to check physical status every 2–4 weeks for an average of 3 months. Results All patients except one showed statistically significant improvements in activities of daily living (ADL) and motor symptoms, as measured by flexion angle at standing posture, Unified Parkinson's Disease Rating Scale (UPDRS) II and III, and modified Hoehn-Yahr staging. Conclusion Conservative treatment is effective in postural correction of camptocormia in Parkinson's disease, as well as improvement in ADL and motor symptoms

Correlation between ambulatory function and clinical factors in hemiplegic patients with intact single lateral corticospinal tract: A pilot study

To define the relationship between the complete destruction of 1 lateral corticospinal tract (CST), as demonstrated by diffusion tensor imaging (DTI) tractography, and ambulatory function 6 months following stroke. Twenty-six adults (17 male, 9 female) with poststroke hemiplegia who were transferred to the physical medicine and rehabilitation department. Participants underwent DTI tractography, which showed that 1 lateral CST had been clearly destroyed. Functional ambulation classification (FAC) scores at admission, discharge, and 6 months after discharge were used to evaluate the patients’ ability to walk. The National Institutes of Health Stroke Scale (NIHSS) and the Korean version of the modified Barthel index (K-MBI) at admission, discharge, and 6 months after discharge were used to evaluate the degree of functional recovery. Of the 26 patients, 18 were nonambulatory (FAC level 1–3), and 8 were able to walk without support (FAC level 4–6). The type of stroke (infarction or hemorrhage), site of the lesion, spasticity of lower extremities, cranioplasty, and the time taken from onset to MRI were not statistically significantly correlated with the ability to walk. However, statistically significant correlations were found in relation to age, K-MBI scores, and initial NIHSS scores. Despite the complete damage to the lesion site and the preservation of 1 unilateral CST, as shown by DTI, good outcomes can be predicted on the basis of younger age, low NIHSS scores, and high MBI scores at onset

The Correlation Between Electrodiagnostic Results and Ultrasonographic Findings in the Severity of Carpal Tunnel Syndrome in Females

Objective: To determine which ultrasonographic measurement can be used as an indicator reflecting the severity of carpal tunnel syndrome (CTS), by comparing electrodiagnostic results with ultrasonographic measurements in females. Many previous studies have tried to reveal that the ultrasonography (US) can possibility be used for diagnosis and severity of CTS. However, the criteria are different by gender. Thus far, there have been many efforts towards providing patients with a CTS diagnosis and severity prediction using US, but studies’ results are still unclear due to lack of data on gender differences. Methods: We collected data from 54 female patients. We classified the severity of CTS according to electrodiagnostic results. Ultrasonographic measurements included proximal and distal cross-sectional areas of the median nerve and carpal tunnel. Results: The severity by electrodiagnostic results statistically correlated to the proximal cross-sectional area (CSA) of the median nerve and carpal tunnel. However, there was no relationship between the proximal and distal nerve/tunnel indexes and the severity by electrodiagnostic results. Conclusion: In female patients with CTS, the proximal CSAs of the median nerve and carpal tunnel increase. They correlate with the severity by electrodiagnostic findings. The CSA of the proximal median nerve could be particularly used as a predictor of the severity of CTS in female patients. However, the nerve/tunnel index is constant, irrespective of the severity of CTS

The Feasibility of Multidimensional CFD Applied to Calandria System in the Moderator of CANDU-6 PHWR Using Commercial and Open-Source Codes

The moderator system of CANDU, a prototype of PHWR (pressurized heavy-water reactor), has been modeled in multidimension for the computation based on CFD (computational fluid dynamics) technique. Three CFD codes are tested in modeled hydrothermal systems of heavy-water reactors. Commercial codes, COMSOL Multiphysics and ANSYS-CFX with OpenFOAM, an open-source code, are introduced for the various simplified and practical problems. All the implemented computational codes are tested for a benchmark problem of STERN laboratory experiment with a precise modeling of tubes, compared with each other as well as the measured data and a porous model based on the experimental correlation of pressure drop. Also the effect of turbulence model is discussed for these low Reynolds number flows. As a result, they are shown to be successful for the analysis of three-dimensional numerical models related to the calandria system of CANDU reactors

Propagation of superconducting coherence via chiral quantum-Hall edge channels

Recently, there has been significant interest in superconducting coherence via chiral quantum-Hall (QH) edge channels at an interface between a two-dimensional normal conductor and a superconductor (N-S) in a strong transverse magnetic field. In the field range where the superconductivity and the QH state coexist, the coherent confinement of electron-and hole-like quasiparticles by the interplay of Andreev reflection and the QH effect leads to the formation of Andreev edge states (AES) along the N-S interface. Here, we report the electrical conductance characteristics via the AES formed in graphene-superconductor hybrid systems in a three-terminal configuration. This measurement configuration, involving the QH edge states outside a graphene-S interface, allows the detection of the longitudinal and QH conductance separately, excluding the bulk contribution. Convincing evidence for the superconducting coherence and its propagation via the chiral QH edge channels is provided by the conductance enhancement on both the upstream and the downstream sides of the superconducting electrode as well as in bias spectroscopy results below the superconducting critical temperature. Propagation of superconducting coherence via QH edge states was more evident as more edge channels participate in the Andreev process for high filling factors with reduced valley-mixing scattering.115Ysciescopu

Is poststroke complex regional pain syndrome the combination of shoulder pain and soft tissue injury of the wrist?: A prospective observational study STROBE of ultrasonographic findings in complex regional pain syndrome

Patients with poststroke complex regional pain syndrome (CRPS) show different symptoms compared to other types of CRPS, as they usually complain of shoulder and wrist pain with the elbow relatively spared. It is thus also known by the term “shoulder-hand syndrome.” The aim of this study is to present a possible pathophysiology of poststroke CRPS through ultrasonographic observation of the affected wrist before and after steroid injection at the extensor digitorum communis (EDC) tendon in patients suspected with poststroke CRPS. Prospective evaluation and observation, the STROBE guideline checklist was used. Twenty-three patients diagnosed as poststroke CRPS in accordance to clinical criteria were enrolled. They had a Three Phase Bone Scan (TPBS) done and the cross-sectional area (CSA) of EDC tendon was measured by using ultrasonography. They were then injected with steroid at the EDC tendon. The CSA of EDC tendon, visual analogue scale (VAS), and degree of swelling of the wrist were followed up 1 week after the injection. TPBS was interpreted as normal for 4 patients, suspected CRPS for 10 patients, and CRPS for 9 patients. Ultrasonographic findings of the affected wrist included swelling of the EDC tendon. After the injection of steroid to the wrist, CSA and swelling of the affected wrist compared to that before the treatment was significantly decreased (P < 0.001). The VAS score declined significantly after the injection (P < 0.001). Our results suggest that the pathophysiology of poststroke CRPS might be the combination of frozen shoulder or rotator cuff tear of shoulder and soft tissue injury of the wrist caused by the hemiplegic nature of patients with stroke

Towards photophoretically levitating macroscopic sensors in the stratosphere

Photophoretic forces could levitate thin 10 centimeter-scale structures in Earth$'$s stratosphere indefinitely. We develop models of the thermal transpiration lofting force on a bilayer sandwich structure under stratospheric conditions driven by radiative fluxes in the thermal-infrared and solar-band. Similar structures have been levitated in the laboratory. Lofting is maximized when the layers are separated by an air gap equal to the mean free path (MFP), when about half of the layers$'$ surface area consists of holes with radii < MFP, and when the top layer is solar-transmissive and infrared-emissive while the bottom layer is solar-absorptive and infrared-transmissive. We describe a preliminary design of a 10 cm diameter device that combines a levitating structure made of two membranes 2 $\mu$m apart with the support structure required for stiffness and orientation control. We limit the design to components that could be fabricated with available methods. Structural analysis suggests that the device would have sufficient strength to withstand forces that might be encountered in transport, deployment, and flight. Our models predict a payload capacity of about 300 mg at 25 km altitude and our analysis suggests it could support bidirectional radio communication at over 10 Mb/s and could have limited navigational abilities. Such devices could be useful for atmospheric science or telecommunications, and similar devices might be useful on Mars. Structures a few times larger might have payloads of a few grams.Comment: Main: 14 pages, 4 figures. Supporting information: 7 pages, 13 figure

Clinical outcomes of FOLFIRINOX in locally advanced pancreatic cancer: A single center experience

Systemic chemotherapy or chemoradiotherapy is the initial primary option for patients with locally advanced pancreatic cancer (LAPC). This study analyzed the effect of FOLFIRINOX and assessed the factors influencing conversion to surgical resectability for LAPC.Sixty-four patients with LAPC who received FOLFIRINOX as initial chemotherapy were enrolled retrospectively. Demographic characteristics, tumor status, interval/dosage/cumulative relative dose intensity (cRDI) of FOLFIRINOX, conversion to resection, and clinical outcomes were reviewed and factors associated with conversion to resectability after FOLFIRINOX were analyzed.After administration of FOLFIRINOX (median 9 cycles, 70% of cRDI), the median patient overall survival (OS) was 17.0 months. Fifteen of 64 patients underwent surgery and R0 resection was achieved in 11 patients. During a median follow-up time of 9.4 months after resection, cumulative recurrence rate was 28.5% at 18 months after resection. The estimated median OS was significantly longer for the resected group (>40 months vs 13 months). There were no statistical differences between the resected and non-resected groups in terms of baseline characteristics, tumor status and hematologic adverse effects. The patients who received standard dose of FOLFIRINOX had higher probability of subsequent resection compared with patients who received reduced dose, although cRDIs did not differ between groups.FOLFIRINOX is an active regimen in patients with LAPC, given acceptable resection rates and promising R0 resection rates. Additionally, our data demonstrate it is advantageous for obtaining resectability to administer FOLFIRINOX without dose reduction