A minimal anonymized data set.

Minimal change disease (MCD) is characterized by edema and nephrotic range proteinuria (NS). However, the fate of MCD without nephrotic proteinuria requires elucidation. We retrospectively reviewed 79 adults diagnosed with primary MCD at their initial renal biopsy at a tertiary hospital between May 2003 and June 2017. Clinicopathologic features were compared between patients with and without NS. The frequency of flaring to nephrotic proteinuria and renal outcomes were assessed during follow-up. There were 20 and 59 patients in the Non-NS and NS groups, respectively. The Non-NS group had a lower frequency of acute kidney injury (AKI) during the follow-up period [5.0% vs. 59.3%, p </div

Outcomes of minimal change disease.

Minimal change disease (MCD) is characterized by edema and nephrotic range proteinuria (NS). However, the fate of MCD without nephrotic proteinuria requires elucidation. We retrospectively reviewed 79 adults diagnosed with primary MCD at their initial renal biopsy at a tertiary hospital between May 2003 and June 2017. Clinicopathologic features were compared between patients with and without NS. The frequency of flaring to nephrotic proteinuria and renal outcomes were assessed during follow-up. There were 20 and 59 patients in the Non-NS and NS groups, respectively. The Non-NS group had a lower frequency of acute kidney injury (AKI) during the follow-up period [5.0% vs. 59.3%, p </div

Progression of proteinuria according to initial amount and treatment.

Progression of proteinuria according to initial amount and treatment.</p

Definitions of MCD courses.

Minimal change disease (MCD) is characterized by edema and nephrotic range proteinuria (NS). However, the fate of MCD without nephrotic proteinuria requires elucidation. We retrospectively reviewed 79 adults diagnosed with primary MCD at their initial renal biopsy at a tertiary hospital between May 2003 and June 2017. Clinicopathologic features were compared between patients with and without NS. The frequency of flaring to nephrotic proteinuria and renal outcomes were assessed during follow-up. There were 20 and 59 patients in the Non-NS and NS groups, respectively. The Non-NS group had a lower frequency of acute kidney injury (AKI) during the follow-up period [5.0% vs. 59.3%, p </div

Effect of presence of nephrotic range proteinuria at diagnosis of MCD on each event.

For presence of AKI at diagnosis, a multiple logistic regression model adjusted for age, sex, serum albumin, eGFR, blood pressures, and severity of podocyte effacement was used. For the first remission in patients with UPCR >3.0 g/g cr: A Cox proportional hazards model adjusted for age; sex; and pathologic findings of deposition of IgA, IgG, lambda chains, or interstitial inflammation, was used. For the first relapse in patients with UPCR (DOCX)</p

Characteristics of patients with minimal change disease according to the highest amount of proteinuria during 6 months before renal biopsy.

Creatinine before biopsy: The lowest value of serum creatinine 6months before renal biopsy, DM: Diabetes mellitus, CHD: Coronary heart disease, SBP: Systolic blood pressure, DBP: Diastolic blood pressure, Cr: Creatinine, GFR: Estimated glomerular filtration rate by CKD-EPI equation, AKI: Acute kidney injury based on the lowest creatinine value during the follow-up period, Max UPCR before biopsy: The highest value of UPCR during the 6 months before biopsy, UPCR: Spot urine protein to creatinine ratio (g/g cr). (DOCX)</p

Renal pathologic findings of patients according to the amount of proteinuria.

LM findings: Light microscopy findings, Mes: Mesangial, IF findings: Immunofluorescent microscopy findings, EM findings: Electron microscopy findings P-values determined using the Mann-Whitney test, uc: Uncountable. (DOCX)</p

Characteristics of patients with minimal change disease according to the amount of proteinuria.

Characteristics of patients with minimal change disease according to the amount of proteinuria.</p

Selection of patients.

MCD: Minimal change disease, SLE: Systemic lupus erythematosus.</p

Outcomes of minimal change disease according to the highest amount of proteinuria during 6 months before renal biopsy.

Min UPCR after biopsy: The lowest value of UPCR during the follow-up period starting 1 month after biopsy, Max UPCR after biopsy: The highest value of UPCR during the follow-up period starting 1 month after biopsy, FU duration after biopsy: Follow-up duration between renal biopsy and the last test of UPCR, RAS: Renin-angiotensin-system, CR: Complete remission of proteinuria 3.0 g/g creatinine after achieving CR of UPCR, SD: Presence of steroid dependency in a patient where relapse of UPCR occurred during steroid tapering or within 2 weeks after cessation of steroids, renal event: Any decrease of GFR of more than 50% during a follow-up visit compared to that at renal biopsy, GFR 2, or development of ESRD, The first CR (n, %) among patients with UPCR >3.00 g/g cr: In the Non-NS group, patients who had increased proteinuria of >3.00 g/g cr during observation period. The first relapse among patients with UPCR (DOCX)</p