The effects of portacaval shunt upon hepatic cholesterol synthesis and cyclic AMP in dogs and baboons

Hepatic cholesterol synthesis, hepatic cyclic AMP, and portal and peripheral insulin and glucagon levels were investigated in nine dogs and three baboons after complete portacaval shunt. Cholesterol synthesis as measured with acetate incorporation was reduced in both species. Hepatic cyclic AMP increased in dogs. Changes in portal and systemic insulin were inconsistent, but hyper-glucagonemia occurred regularly. Diminished hepatic cholesterol synthesis is apparently one factor, although probably not the only one, in the antilipidemic effect of portacaval shunt. This altered cholesterol metabolism may be due to a change in the hormonal environment of the liver caused by portal diversion

The effect of splanchnic viscera removal upon canine liver regeneration

The influence of portal blood factors on canine liver regeneration was studied with graded nonhepatic splanchnic evisceration, coupled with 44 and 72 per cent hepatectomies. In one type of experiment, the pancreas was retained while the rest of the intra-abdominal gastrointestinal tract was removed. In a second variety, total pancreatectomy was performed with preservation of the intra-abdominal organs. In a third kind of experiment, total nonhepatic splanchnic evisceration was performed. Liver regeneration after hepatectomy was decreased by all three kinds of viscera removed as judged by deoxyribonucleic acid synthesis, autoradiography and mitotic index. Pancreatectomy and nonpancreatic splanchnic evisceration caused almost equal decreases in the regenerative response. Total nonhepatic splanchnic evisceration essentially halted regeneration during the first three postoperative days and intraportal infusions of insulin or glucagon, or both together, did not reverse this effect. The decrease in liver membrane bound adenyl cyclase activity and biphasic change in liver cyclic 3',5'-adenosine monophosphate concentrations normally seen partial hepatectomy was disrupted after the various eviscerations. Adenyl cyclase activity and cyclic monophosphate concentrations tended to be higher than normal in the eviscerated dogs. These observations provide more support for our previously proposed hypothesis that control of liver regeneration is by multiple factors. Pancreatic hormones are important modifiers of this response but by no means exercise exclusive control. Other substances of gastrointestinal origin, presumably including hormones and nutrient supply apparently play important specific roles. The volume of portal flow is a secondary and nonspecific, but possibly significant, factor

Impaired clearance of ceftizoxime and cefotaxime after orthotopic liver transplantation.

The pharmacokinetics of ceftizoxime (CZX) and of cefotaxime (CTX) were studied in five children and five adults after orthotopic liver transplantation (OLT). Delayed clearance of CZX (clearance of 0.21 to 1.26 ml/min per kg [body weight]) and CTX (clearance of 0.40 to 1.49 ml/min per kg) occurred in 7 of the 10 OLT patients. We conclude that abnormal CZX and CTX clearance is common after OLT and may be associated with minimal change in serum creatinine

Development Finance Institutions and the Coronavirus Crisis

Key messages: Development finance institutions (DFIs) are mandated by their shareholders to provide finance to the private sector (usually at commercial terms, but subsidised implicitly), crowd in private sector finance and have a development impact; While DFIs aim to be additional to the market, they have not been sufficiently counter-cyclical in past crises. That has to change,as poor country firms and their workers face major hardship now. Today’s crisis is larger than those in the past; We suggest shareholders provide regulatory and financial space for DFIs to fast-track new investments, allow for some repaymentpostponements and announce a Bounce Back Better facility, to save companies and workers from bankruptcy and to protectprevious transformation efforts so that the bounce-back is faster and better

Designing the Optimal Bit: Balancing Energetic Cost, Speed and Reliability

We consider the technologically relevant costs of operating a reliable bit that can be erased rapidly. We find that both erasing and reliability times are non-monotonic in the underlying friction, leading to a trade-off between erasing speed and bit reliability. Fast erasure is possible at the expense of low reliability at moderate friction, and high reliability comes at the expense of slow erasure in the underdamped and overdamped limits. Within a given class of bit parameters and control strategies, we define "optimal" designs of bits that meet the desired reliability and erasing time requirements with the lowest operational work cost. We find that optimal designs always saturate the bound on the erasing time requirement, but can exceed the required reliability time if critically damped. The non-trivial geometry of the reliability and erasing time-scales allows us to exclude large regions of parameter space as sub-optimal. We find that optimal designs are either critically damped or close to critical damping under the erasing procedure

Why do Maori Disconnect? From their tikanga and legal associated rights and responsibilities within a contemporary world

This thesis examines some of the reasons why Māori disconnect from their legal and tikanga rights and responsibilities within the contemporary world of today. The aim of this research project is to identify some of the associated rights and responsibilities of Māori - as land owners, shareholders, Whānau, hapū and tribal members. Whilst it seeks to reveal some of the desires and visions of the interview participants, the objective is not to seek resolution. The focus is to identify what deters or dissuades owners from returning and/or participating. It also seeks to identify whether the assumption or label of disconnection is a reality or myth. ‘Māori Diaspora’ particularly refers to the substantial increase in outward migration (also referred to as out migration) of Māori leaving New Zealand, and more significantly migrating to Australia, which was in direct response to the neo-liberal reforms of the late 1980’s (Smith L. , 2006). With the New Zealand government refusing to acknowledge the negative impact their legislation and policy had on Māori, they continued to introduce new systems that were ultimately designed to push many to breaking point. Māori who could no longer bear the cumulative effects of such oppression emigrated in search of better economic opportunities and a higher standard of living for their families. Meanwhile, back home in Aotearoa, the Māori Diaspora left behind a complex set of problems in its wake with diminishing hapū and tribal members driven from their homeland who are gradually becoming dis-connected and estranged from their whenua tipu. Whilst repatriation is an uncomfortable topic for many Māori who wish to retain their overseas residency, many continue to dismiss the compounding effects of their absence and the heavy burden carried by those who remain in Aotearoa to keep the home fires burning (or the ‘ahi kaa’)

GROWTH-STIMULATING FACTOR IN REGENERATING CANINE LIVER

Extracts from dog livers which had been regenerating for 24, 48, and 72 h after hepatectomy were infused for 6 h into the left portal vein of animals which had fresh portacaval shunts (Eck fistula) and which were killed 2 and 3 days later. The brief exposure to the 48-h and especially the 72-h regenerating liver extracts induced a delayed proliferative response predominantly in the left liver lobes, with a slight spillover effect to the right liver lobes but none to the kidney. The response reached its peak 3 days later. In the left but not the right liver lobes, both the 48-h and the 72-h regenerating liver extract reversed the atrophy ordinarily caused by Eck fistula in 3 days and partly prevented the ultrastructural hepatocyte deterioration characteristic of Eck fistula. The active liver extracts apparently contained a growth-control factor or factors which is (are) not insulin or glucagon. © 1979